Results 51 to 60 of about 993,506 (266)
Medžiagotyra, 2011 In this paper validation of experimental and numerical results of low-velocity impact tests of unsaturated polyester/glass fibre composite laminate has been carried out.
Sanita ZIKE +3 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Frontiers in Human NeuroscienceObjectiveEarly speech experiences are presumed to contribute to the development of brain structures involved in processing speech. Previous research has been limited to correlational studies.
Katherine E. Travis +12 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
"C-scan" ultrasound imaging of optic nerve extension of retinoblastoma [PDF]
British Journal of Ophthalmology, 2005 Three dimensional ultrasound based coronal “C-scan” imaging technique was used to demonstrate optic nerve extension of retinoblastoma. With a clinical diagnosis of retinoblastoma based on clinical evaluation, ultrasound, and computed radiographic tomography, this patient was treated by primary enucleation. Subsequent histopathological evaluation of the
openaire +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Evaluation Of Ultrasonic C-Scan Images By Fractal Dimension
, 2012 {"references": ["B. B. Mandelbrot, and J. W. Wallis, \"Fractional Brownian Motions,\"\nFractional Noises and Applications, SIAM review, 10: 422-437, 1968.", "B. B. Mandelbrot, \"The Fractal Geometry of Nature,\" W. H. Freeman,\nSan Francisco, CA, 1982.", "A. P.
S. Samanta, D. Datta, S. S. Gautam
openaire +2 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source