Results 51 to 60 of about 995,411 (266)
ObjectiveEarly speech experiences are presumed to contribute to the development of brain structures involved in processing speech. Previous research has been limited to correlational studies.
Katherine E. Travis +12 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
In this paper validation of experimental and numerical results of low-velocity impact tests of unsaturated polyester/glass fibre composite laminate has been carried out.
Sanita ZIKE +3 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
"C-scan" ultrasound imaging of optic nerve extension of retinoblastoma [PDF]
Three dimensional ultrasound based coronal “C-scan” imaging technique was used to demonstrate optic nerve extension of retinoblastoma. With a clinical diagnosis of retinoblastoma based on clinical evaluation, ultrasound, and computed radiographic tomography, this patient was treated by primary enucleation. Subsequent histopathological evaluation of the
openaire +1 more source
Discerning protein pools by selective staining with self‐labeling tags
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Evaluation Of Ultrasonic C-Scan Images By Fractal Dimension
{"references": ["B. B. Mandelbrot, and J. W. Wallis, \"Fractional Brownian Motions,\"\nFractional Noises and Applications, SIAM review, 10: 422-437, 1968.", "B. B. Mandelbrot, \"The Fractal Geometry of Nature,\" W. H. Freeman,\nSan Francisco, CA, 1982.", "A. P.
S. Samanta, D. Datta, S. S. Gautam
openaire +2 more sources
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source

