Results 121 to 130 of about 25,168,555 (296)

Intradomain Allosteric Network Modulates Calcium Affinity of the C‑Type Lectin Receptor Langerin [PDF]

, 2016
Antigen uptake and processing by innate immune cells is crucial to initiate the immune response. Therein, the endocytic C-type lectin receptors serve as pattern recognition receptors, detecting pathogens by their glycan structures. Herein, we studied the
Christoph Rademacher (1819219), Rademacher, C., Marcel Jurk (189033), Peter Schmieder (189036), Jurk, M., Martin Ballaschk (3108639), Shanina, E., Stevan Aleksić (3108642), Hanske, J., Elena Shanina (3108645), Monika Beerbaum (2421244), Bettina G. Keller (1333797), Schmieder, P., Ballaschk, M., Beerbaum, M., Aleksić, S., Jonas Hanske (1819210), Keller, B.   +17 more
core   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Mannose and Lactobionic Acid in Nasal Vaccination: Enhancing Antigen Delivery via C-Type Lectin Receptors

Pharmaceutics
Background/Objectives: Nasal vaccines are a promising strategy for enhancing mucosal immune responses and preventing diseases at mucosal sites by stimulating the secretion of secretory IgA, which is crucial for early pathogen neutralization.
Mariana Colaço, Maria T. Cruz, Luís Pereira de Almeida, Olga Borges   +3 more
doaj   +1 more source

The pattern recognition receptors dectin-2, mincle, and FcRγ impact the dynamics of phagocytosis of Candida, Saccharomyces, Malassezia, and Mucor species.

PLoS ONE, 2019
Phagocytosis is a receptor-mediated process critical to innate immune clearance of pathogens. It proceeds in a regulated sequence of stages: (a) migration of phagocytes towards pathogens, (b) recognition of PAMPs and binding through PRRs, (c) engulfment ...
Mohammed Haider, Ivy M Dambuza, Patawee Asamaphan, Mark Stappers, Delyth Reid, Sho Yamasaki, Gordon D Brown, Neil A R Gow, Lars P Erwig   +8 more
doaj   +1 more source

Monocyte galactose/N-acetylgalactosamine-specific C-type lectin receptor stimulant immunotherapy of an experimental glioma. Part II: combination with external radiation improves survival

, 2012
Sergiy V Kushchayev,1 Tejas Sankar,1 Laura L Eggink,5,6 Yevgeniya S Kushchayeva,5 Philip C Wiener,1,5 J Kenneth Hoober,5,6 Jennifer Eschbacher,3 Ruolan Liu,2 Fu-Dong Shi,2 Mohammed G Abdelwahab,4 Adrienne C Scheck,4 Mark C Preul11Neurosurgery Research ...
Wiener PC, Sankar T, Eschbacher J, Kushchayev SV, Shi FD, Eggink LL, Scheck AC, Kushchayeva YS, Hoober JK, Liu R, Preul MC, Abdelwahab MG   +11 more
core  

ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences

, 2018
Understanding blood group antigen binding preferences for C-type lectin receptors holds promise for modulating immune responses, since several Gram-negative bacteria express blood group antigens as molecular mimicry to evade immune responses.
Balamurugan Subramani, Chethan D. Shanthamurthy, Sharon Yehuda, Vered Padler-Karavani, João T. Monteiro, Bernd Lepenies, Prashant Jain, Raghavendra Kikkeri, Shani Leviatan Ben-Arye   +8 more
core   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

C-type lectin-like receptor 2 in platelets amplifies inflammation in rheumatoid arthritis

Research and Practice in Thrombosis and Haemostasis
Background: Platelets play a crucial role not only in thrombosis and hemostasis but also in inflammation, including rheumatoid arthritis. Although synovial cells in the joints express the membrane protein podoplanin, and platelets express the podoplanin ...
Tomoyuki Sasaki, Ewelina Golebiewska, Toshiaki Shirai, Nagaharu Tsukiji, Kensuke Koyama, Shogo Tamura, Shimon Otake, Makoto Osada, Hirotaka Haro, Yukio Ozaki, Katsue Suzuki–Inoue   +10 more
doaj   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

DectiSomes: C-type lectin receptor-targeted liposomes as pan-antifungal drugs. [PDF]

Adv Drug Deliv Rev, 2023
Meagher RB, Lewis ZA, Ambati S, Lin X.
europepmc   +1 more source