Results 101 to 110 of about 168,647 (296)

Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems

Advanced Science, EarlyView.
A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller, Amelie Maribel Schneider, Ellen Sjule, Renhua Sun, Xiao Han, Luca Andronico, Edward Jenkins, Michael Dustin, Adnane Achour, Erdinc Sezgin   +9 more
wiley   +1 more source

Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis

BMC Medical Genetics, 2010
Background Mannose receptor (MR) is a member of the C-type lectin receptor family involved in pathogen molecular-pattern recognition and thought to be critical in shaping host immune response.
Hizawa Nobuyuki, Yamaguchi Etsuro, Gao Peisong, Taniguchi Natsuko, Shimizu Kenichi, Shimizu Kaoruko, Isada Akira, Takahashi Ayumu, Konno Satoshi, Hattori Takeshi, Huang Shau-Ku, Nishimura Masaharu   +11 more
doaj   +1 more source

One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy

Advanced Science, EarlyView.
This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu, Ben Huang, Lingyan Wang, Qiang Guo, Cuiping Jiang, Ruicheng Qi, Shuyao Wang, Lin‐Tai Da, Wenjie Peng   +8 more
wiley   +1 more source

Over-expression of an S-domain receptor-like kinase extracellular domain improves panicle architecture and grain yield in rice. [PDF]

, 2015
The S-domain receptor kinase (SRK) comprises a highly polymorphic subfamily of receptor-like kinases (RLKs) originally found to be involved in the self-incompatibility response in Brassica.
Li, Hongyu, Lin, Chentao, Liu, Bin, Liu, Jun, Qin, Zhengrui, Zhang, Chengsheng, Zhang, Chunyu, Zhao, Tao, Zou, Xiaohua   +8 more
core   +2 more sources

Transdermal Delivery of an mRNA‐Liposome Vaccine via Dissolving Microneedle to Preserve Vaccine Activity and Enhance Immune Activation

Advanced Science, EarlyView.
An mRNA‐liposome vaccine via dissolving microneedles (ML‐DMN) enables efficient skin‐targeted delivery while preserving mRNA integrity and allowing sustained antigen expression. Unlike intramuscular (IM) injection, ML‐DMN engages skin‐resident immune cells, activates antigen‐presenting cells (APCs), and induces strong T cell and cytokine responses at ...
Jeehye Nam, JiWon Ahn, Jiwoo Shin, Nahong Lee, Youjin Lee, Sung min Cho, Paul Kim, Geonwoo Kang, Sang‐Jun Ha, Hyungil Jung   +9 more
wiley   +1 more source

Parasitic Infections: A Role for C-Type Lectins Receptors

BioMed Research International, 2013
Antigen-presenting cells (APCs) sense the microenvironment through several types of receptors that recognize pathogen-associated molecular patterns. In particular, C-type lectins receptors (CLRs), which are expressed by distinct subsets of dendritic cells (DCs) and macrophages (MØs), recognize and internalize specific carbohydrate antigens in a Ca2 ...
Vázquez-Mendoza, Alicia, Carrero, Julio César, Rodriguez-Sosa, Miriam   +2 more
openaire   +2 more sources

FGB1 and WSC3 are in planta-induced beta-glucan-binding fungal lectins with different functions [PDF]

, 2019
In the root endophyte Serendipita indica, several lectin-like members of the expanded multigene family of WSC proteins are transcriptionally induced in planta and are potentially involved in beta-glucan remodeling at the fungal cell wall.
Becker, S., Fesel, P., Hehemann, J., Lahrmann, U., Langen, G., Neumann, U., Wawra, S., Widmer, H., Zuccaro, A.   +8 more
core   +2 more sources

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Genetic variation in the C-type lectin receptor CLEC4M in type 1 von Willebrand Disease patients.

PLoS ONE, 2018
von Willebrand factor (VWF) levels in healthy individuals and in patients with type 1 von Willebrand disease (VWD) are influenced by genetic variation in several genes, e.g. VWF, ABO, STXBP5 and CLEC4M.
Eric Manderstedt, Christina Lind-Halldén, Stefan Lethagen, Christer Halldén   +3 more
doaj   +1 more source

AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival [PDF]

, 2014
Biomechanical strain imposed by age-related thickening of the basal lamina and augmented tissue stiffness in the prostate gland coincides with increased cancer risk. Here we hypothesized that the structural alterations in the basal lamina associated with
Breit, Claudia, Caley, Matthew P., Cox, Thomas R, Darby, Steven, Erler, Janine T, Gaughan, Luke, Gronau, Julian H., Mauri, Francesco, McCarthy, Afshan, Minamidate, Ai, Robson, Craig, Rodriguez-Teja, Mercedes, Sturge, Justin, Waxman, Jonathan, Zhang, Yu Zhi   +14 more
core   +1 more source