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C-type lectins (CTLs) form a broad and diverse protein superfamily with the ability to identify a wide array of ligands with their characteristic C-type lectin-like domains (CTLDs), thus governing a broad spectrum of physiological functions. CTLD-containing proteins (CTLDcps) are now classified into 17 groups based on their phylogeny and overall domain
Kasturi, Ganguly, Taruna, Madan
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Kasturi, Ganguly, Taruna, Madan
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C-Type Lectin Receptors Orchestrate Antifungal Immunity
Future Microbiology, 2013Fungal infections are an emerging threat for human health. A coordinated host immune response is fundamental for successful elimination of an invading fungal microbe. A panel of C-type lectin receptors expressed on antigen-presenting dendritic cells enable innate recognition of fungal cell wall carbohydrates and tailors adaptive responses via the ...
Brigitte A, Wevers +2 more
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The role of C-type lectin receptors in immune homeostasis
International Immunopharmacology, 2013C-type lectin receptors (CLRs) are important pathogen pattern recognition molecules that recognize carbohydrate structures. Upon ligand binding, CLRs induce a variety of cellular responses, such as respiratory burst, production of cytokines and chemokines, and consequently shaping the adaptive immune responses. Recent frontier studies have demonstrated
Huimin, Yan +2 more
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C-type lectin receptors on dendritic cells and langerhans cells
Nature Reviews Immunology, 2002Dendritic cells and Langerhans cells are specialized for the recognition of pathogens and have a pivotal role in the control of immunity. As guardians of the immune system, they are present in essentially every organ and tissue, where they operate at the interface of innate and acquired immunity.
Figdor, C.G., Kooyk, Y. van, Adema, G.J.
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The CD94/NKG2 C-Type Lectin Receptor Complex
1998A multigene family of human Ig-SF receptors and members of the murine Ly49 C-type lectin family are involved in natural killer (NK) cell-mediated recognition of MHC class I molecules. The human CD94 glycoprotein covalently assembles with different C-type lectins of the NKG2 family.
M, López-Botet +5 more
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Screening for Ligands of C-Type Lectin-Like Receptors
2011In order to execute their immune functions, leukocytes interact with a broad range of cell types through cell surface receptors, such as those of the immunoglobulin and C-type lectin families, or indirectly through soluble factors. The characterization of activating and inhibitory counterparts of NK cell receptors on myeloid cells, as well as the ...
Elwira, Pyż, Gordon D, Brown
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Structural Aspects of C-Type Lectin Receptors
2016Numerous structural analyses (X-ray crystallography and NMR) of C-type lectin receptors (CLRs) have been performed, because CLRs are not only attractive as important molecules in immunity and infectious diseases but also as drug targets. In CLRs, high amino acid sequence similarity exists in the extracellular carbohydrate recognition domains (CRDs ...
Atsushi Furukawa +4 more
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Targeting C-type lectin receptors with multivalent carbohydrate ligands
Advanced Drug Delivery Reviews, 2013C-type lectin receptors (CLRs) represent a large receptor family including collectins, selectins, lymphocyte lectins, and proteoglycans. CLRs share a structurally homologous carbohydrate-recognition domain (CRD) and often bind carbohydrates in a Ca²⁺-dependent manner.
Lepenies, B., Lee, J., Sonkaria, S.
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