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C-Type Lectin Receptors in Phagocytosis
2020C-type lectin receptors (CLRs) are a family of transmembrane proteins having at least one C-type lectin-like domain (CTLD) on the cell surface and either a short intracellular signaling tail or a transmembrane domain that facilitates interaction with a second protein, often the Fc receptor common gamma chain (FcRγ), that mediates signaling.
Kai, Li, David M, Underhill
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C-Type Lectin Receptors in Antifungal Immunity
2020Most fungal species are harmless to humans and some exist as commensals on mucocutaneous surfaces. Yet many fungi are opportunistic pathogens, causing life-threatening invasive infections when the immune system becomes compromised. The fungal cell wall contains conserved pathogen-associated molecular patterns (PAMPs), which allow the immune system to ...
Christina, Nikolakopoulou +2 more
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C-type lectin receptors in antifungal immunity
Trends in Microbiology, 2008Fungal infections represent a significant health burden, especially in immunocompromised individuals, yet many of the underlying immunological mechanisms involved in the recognition and control of these pathogens are unclear. The identification of the Toll-like receptors (TLRs) has shed new insights on innate microbial recognition and the initiation of
Janet A, Willment, Gordon D, Brown
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C-type lectin receptors in anti-fungal immunity
Current Opinion in Microbiology, 2017Host immune systems are constantly engaged with fungal pathogens which are common in environments as well as in healthy human skin and mucosa. C-type lectin receptors (CLRs) are expressed in myeloid cells and play central roles in host defenses against fungal infections by coordinating innate and adaptive immune systems.
Moe, Shiokawa +2 more
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Signaling C-Type Lectin Receptors in Antifungal Immunity
2020We are all exposed to fungal organisms daily, and although many of these organisms are not harmful, billions of people a year contract a fungal infection. Most of these infections are not fatal and can be cleared by the host immune response. However, due to an increase in high-risk populations, the global fungal burden has increased, with more than 1.5
Maxine A, Höft +2 more
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Immunobiology of C-Type Lectin Receptors
2013C-type lectin receptors (CLRs) that signal via the kinase Syk are an important class of pattern recognition receptors in the innate immune system. They recognize pathogen- and host-derived danger signals, and are best known for their role in antifungal immunity.
Susanne Roth +2 more
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Archaeal Glycerolipids Are Recognized by C-Type Lectin Receptor Mincle
Journal of the American Chemical Society, 2023Recently, various metabolites derived from host microbes have been reported to modulate the immune system, with potential involvement in health or diseases. Archaea, prokaryotic organisms, are present in the human body, but their connection with the host is largely unknown when compared to other microorganisms such as bacteria.
Shiori Oka +10 more
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C-type lectin receptors and cytokines in fungal immunity
Cytokine, 2012Fungi are the cause of opportunistic infections, predominantly in immunocompromised individuals although, primary fungal infections can occur in apparently healthy individuals. Successful host defence requires an effective innate and adaptive immune response.
Simon, Vautier +2 more
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