Results 131 to 140 of about 149 (148)

Role of natriuretic peptide clearance receptor in in vivo control of C-type natriuretic peptide

American Journal of Physiology-Heart and Circulatory Physiology, 1995
C-type natriuretic peptide (CNP) is a newly described 22-amino acid peptide of endothelial cell origin, which has selective cardiovascular actions and is structurally related to atrial natriuretic peptide (ANP). Recent in vitro studies have demonstrated that an important regulatory pathway for the clearance of natriuretic peptides involves binding to ...
Roland R. Brandt, John C. Burnett, J. A. Lewicki, Denise M. Heublein, Lawrence L. Aarhus   +4 more
openaire   +3 more sources

Mechanisms of Action of Atrial Natriuretic Factor and C-Type Natriuretic Peptide

Hypertension, 1996
Abstract After secretion by the heart, atrial natriuretic factor (ANF) circulates in plasma, whereas C-type natriuretic peptide (CNP), which is found in abundance in the endothelium, may regulate vascular tone in a paracrine manner. However, there is little information on the effect of CNP on renal microvessels. We hypothesized
Janki Amin, Sadayoshi Ito, Oscar A. Carretero   +2 more
openaire   +3 more sources

C-type Natriuretic Peptide: An Important Neuroendocrine Regulator?

Trends in Endocrinology & Metabolism, 2000
In the decade since its discovery, C-type natriuretic peptide (CNP), the third member of the natriuretic peptide family, has been shown to be produced by most of the major endocrine glands, including the hypothalamus and anterior pituitary. The relative abundance of its guanylyl cyclase-containing GC-B receptor in these glands suggests that CNP might ...
Robert C. Fowkes, Craig A. McArdle
openaire   +3 more sources

Cardiovascular and renal actions of C-type natriuretic peptide

American Journal of Physiology-Heart and Circulatory Physiology, 1992
Studies were performed in two groups of anesthetized dogs (n = 5 per group) to determine the cardiovascular and renal actions of synthetic C-type natriuretic peptide (CNP). Systemic infusion of CNP (group 1; 10 and 50 ng.kg-1.min-1 iv) resulted in marked cardiovascular hemodynamic effects characterized by a decrease in mean arterial pressure, cardiac ...
Alfredo L. Clavell, Lawrence L. Aarhus, John C. Burnett, A. J. Stingo   +3 more
openaire   +3 more sources

C-TYPE NATRIURETIC PEPTIDE (CNP) IN RATS AND HUMANS

Endocrinology, 1991
We have established a specific radioimmunoassay (RIA) for C-type natriuretic peptide (CNP), the third member of the natriuretic peptide family, and have elucidated its tissue distribution and molecular form. In rats, high concentrations of CNP-like immunoreactivity (-LI) were detected in the anterior lobe (19.8 +/- 8.6 pmol/g) and neurointermediate ...
Yoshihiro Ogawa, Shin Ichi Suga, Norio Hama, Masashi Mukoyama, Ichiro Kishimoto, Hiroshi Arai, Osamu Nakagawa, Yasato Komatsu, Gotaro Shirakami, Hiroo Imura, Kazuwa Nakao, Kiminori Hosoda   +11 more
openaire   +3 more sources

C-type natriuretic peptide system in rabbit oviduct

Peptides, 2001
C-type natriuretic peptide (CNP), a third member of the natriuretic peptide family, is known to be distributed mainly in brain and vascular endothelium and is considered to act as a local regulator in many tissues. The purpose of this study was to determine the presence of CNP system and its biological function in rabbit oviduct.
Kyung Woo Cho, Suhn Hee Kim, Kyung Hwan Seul, Sook Jeong Lee, Sung Zoo Kim, Kyung Sun Lee   +5 more
openaire   +3 more sources

Mechanism of relaxations to C-type natriuretic peptide in veins

American Journal of Physiology-Heart and Circulatory Physiology, 1996
C-type natriuretic peptide (CNP) is an endothelium-derived peptide that shares structural homology with atrial natriuretic peptide (ANP). CNP causes greater endothelium-independent relaxations in veins compared with arteries. Relaxations to CNP in porcine coronary arteries are mediated by hyperpolarization of the smooth muscle membrane.
Virginia M. Miller, Cheol H. Kim, Chi Ming Wei, John C. Burnett, Michelle Banks   +4 more
openaire   +3 more sources

C-type natriuretic peptide system in rabbit colon

Peptides, 2001
C-type natriuretic peptide (CNP) is mainly distributed in the brain and vascular endothelium and is considered to act as a local regulator in many tissues. The present study was aimed to determine the presence of CNP system and its biological function in rabbit colon.
Kyung Woo Cho, Sung Zoo Kim, Goan Hee Jeon, Jong Hun Kim, Suhn Hee Kim   +4 more
openaire   +3 more sources

C-type natriuretic peptide in vascular physiology and disease

Pharmacology & Therapeutics, 2005
Natriuretic peptides play a critical role in coordination of fluid/electrolyte balance and vascular tone. The renal effects of circulating atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are distinct from the paracrine effects of vascular C-type natriuretic peptide (CNP).
Amrita Ahluwalia, Ramona S. Scotland, Adrian J. Hobbs   +2 more
openaire   +2 more sources

Detection of C-type natriuretic peptide in fetal circulation

Journal of Perinatal Medicine, 2000
C-type natriuretic peptide (CNP) belongs to the natriuretic peptide family that plays an important role in the control of blood pressure, renal function and volume homeostasis. In contrast to the atrial natriuretic peptide and brain natriuretic peptide, CNP acts in an autocrine/paracrine fashion and is considered to be the endothelial component of the ...
Thomas Walther, Diego J. Walther, Holger Stepan, Renaldo Faber   +3 more
openaire   +3 more sources