Results 111 to 120 of about 69,767 (155)

C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid

Brain Research, 1993
In order to investigate whether C-type natriuretic peptide (CNP) is present in human cerebrospinal fluid (CSF), we measured CNP-like immunoreactivity (-LI) in human CSF by specific radioimmunoassay (RIA) for CNP. We also measured atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) concentrations in human CSF. ANP-LI, BNP-LI, and CNP-LI
Takaaki Kaneko, Gotaro Shirakami, Kazuwa Nakao, Izumi Nagata, Osamu Nakagawa, Norio Hama, Shin-ichi Suga, Susumu Miyamoto, Hiroaki Kubo, Osamu Hirai, Haruhiko Kikuchi, Hiroo Imura   +11 more
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Role of natriuretic peptide clearance receptor in in vivo control of C-type natriuretic peptide

American Journal of Physiology-Heart and Circulatory Physiology, 1995
C-type natriuretic peptide (CNP) is a newly described 22-amino acid peptide of endothelial cell origin, which has selective cardiovascular actions and is structurally related to atrial natriuretic peptide (ANP). Recent in vitro studies have demonstrated that an important regulatory pathway for the clearance of natriuretic peptides involves binding to ...
R R, Brandt, D M, Heublein, L L, Aarhus, J A, Lewicki, J C, Burnett   +4 more
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Selective Activation of the B Natriuretic Peptide Receptor by C-Type Natriuretic Peptide (CNP)

Science, 1991
The natriuretic peptides are hormones that can stimulate natriuretic, diuretic, and vasorelaxant activity in vivo, presumably through the activation of two known cell surface receptor guanylyl cyclases (ANPR-A and ANPR-B). Although atrial natriuretic peptide (ANP) and, to a lesser extent, brain natriuretic peptide (BNP) are efficient activators of the ...
K J, Koller, D G, Lowe, G L, Bennett, N, Minamino, K, Kangawa, H, Matsuo, D V, Goeddel   +6 more
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N-terminal pro-C-type natriuretic peptide, but not C-type natriuretic peptide, is greatly elevated in the fetal circulation

Clinical Science, 2004
We have identified recently a new peptide, NT-proCNP(1–50) (N-terminal pro-C-type natriuretic peptide), in the circulation of humans and sheep. A previous report of an elevated fetal–maternal gradient in immunoreactive CNP raised the possibility that processing and metabolism of proCNP may differ in maternal and fetal tissues.
Timothy C R, Prickett, Risto J, Kaaja, M Gary, Nicholls, Eric A, Espiner, A Mark, Richards, Timothy G, Yandle   +5 more
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Mechanisms of Action of Atrial Natriuretic Factor and C-Type Natriuretic Peptide

Hypertension, 1996
Abstract After secretion by the heart, atrial natriuretic factor (ANF) circulates in plasma, whereas C-type natriuretic peptide (CNP), which is found in abundance in the endothelium, may regulate vascular tone in a paracrine manner. However, there is little information on the effect of CNP on renal microvessels. We hypothesized
J, Amin, O A, Carretero, S, Ito
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C-type Natriuretic Peptide: An Important Neuroendocrine Regulator?

Trends in Endocrinology & Metabolism, 2000
In the decade since its discovery, C-type natriuretic peptide (CNP), the third member of the natriuretic peptide family, has been shown to be produced by most of the major endocrine glands, including the hypothalamus and anterior pituitary. The relative abundance of its guanylyl cyclase-containing GC-B receptor in these glands suggests that CNP might ...
R C, Fowkes, C A, McArdle
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Mechanism of relaxations to C-type natriuretic peptide in veins

American Journal of Physiology-Heart and Circulatory Physiology, 1996
C-type natriuretic peptide (CNP) is an endothelium-derived peptide that shares structural homology with atrial natriuretic peptide (ANP). CNP causes greater endothelium-independent relaxations in veins compared with arteries. Relaxations to CNP in porcine coronary arteries are mediated by hyperpolarization of the smooth muscle membrane.
M, Banks, C M, Wei, C H, Kim, J C, Burnett, V M, Miller   +4 more
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Cardiovascular and renal actions of C-type natriuretic peptide

American Journal of Physiology-Heart and Circulatory Physiology, 1992
Studies were performed in two groups of anesthetized dogs (n = 5 per group) to determine the cardiovascular and renal actions of synthetic C-type natriuretic peptide (CNP). Systemic infusion of CNP (group 1; 10 and 50 ng.kg-1.min-1 iv) resulted in marked cardiovascular hemodynamic effects characterized by a decrease in mean arterial pressure, cardiac ...
A J, Stingo, A L, Clavell, L L, Aarhus, J C, Burnett   +3 more
openaire   +2 more sources

Detection of C-type natriuretic peptide in fetal circulation

Journal of Perinatal Medicine, 2000
C-type natriuretic peptide (CNP) belongs to the natriuretic peptide family that plays an important role in the control of blood pressure, renal function and volume homeostasis. In contrast to the atrial natriuretic peptide and brain natriuretic peptide, CNP acts in an autocrine/paracrine fashion and is considered to be the endothelial component of the ...
H, Stepan, D, Walther, R, Faber, T, Walther   +3 more
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C-type natriuretic peptide in vascular physiology and disease

Pharmacology & Therapeutics, 2005
Natriuretic peptides play a critical role in coordination of fluid/electrolyte balance and vascular tone. The renal effects of circulating atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are distinct from the paracrine effects of vascular C-type natriuretic peptide (CNP).
Ramona S, Scotland, Amrita, Ahluwalia, Adrian J, Hobbs   +2 more
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