Results 131 to 140 of about 69,627 (255)

C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis. [PDF]

Proc Natl Acad Sci U S A, 2022
Perez-Ternero C, Aubdool AA, Makwana R, Sanger GJ, Stimson RH, Chan LF, Moyes AJ, Hobbs AJ.   +7 more
europepmc   +1 more source

Probable sepsis‐associated encephalopathy as a component of multiple organ dysfunction syndrome in a cat with pyothorax

Australian Veterinary Journal, EarlyView.
A 2‐year‐old male neutered domestic shorthair cat with bacterial pyothorax was referred to a tertiary hospital for treatment of sepsis. He met criteria for multiple organ dysfunction syndrome and developed new‐onset neurological dysfunction subsequent to the development of sepsis.
CC Chan, CR Sharp, CJ Boyd
wiley   +1 more source

C-Type Natriuretic Peptide Preserves Vascular and Cardiac Function in Sepsis. [PDF]

Hypertension
Moyes AJ, Sand C, Young L, Pérez-Ternero C, Salam AT, Baliga RS, Mohammad S, Antcliffe DB, Gordon AC, Aubdool AA, Hobbs AJ.   +10 more
europepmc   +1 more source

Molecular Mechanism of Induction of Bone Growth by the C-Type Natriuretic Peptide. [PDF]

Int J Mol Sci, 2022
Rintz E, Węgrzyn G, Fujii T, Tomatsu S.
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Collagen-binding C-type natriuretic peptide enhances chondrogenesis and osteogenesis. [PDF]

JCI Insight
Hirai K, Sawamura K, Esaki R, Sawada R, Okusha Y, Aoyama E, Saito H, Uchida K, Mima T, Kubota S, Tsukahara H, Imagama S, Matsushita M, Matsushita O, Hosono Y.   +14 more
europepmc   +1 more source

Circulatory C-type natriuretic peptide reduces mucopolysaccharidosis-associated craniofacial hypoplasia in vivo. [PDF]

PLoS One, 2022
Kashiwagi M, Nakao K, Yamanaka S, Yamauchi I, Yamashita T, Fujii T, Ueda Y, Kawai MY, Watanabe T, Fukuhara S, Bessho K.   +10 more
europepmc   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

C-Type Natriuretic Peptide (CNP) Could Improve Sperm Motility and Reproductive Function of Asthenozoospermia. [PDF]

Int J Mol Sci, 2022
Li N, Dong X, Fu S, Wang X, Li H, Song G, Huang D.   +6 more
europepmc   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source