Results 201 to 210 of about 105,541 (302)

C Type Natriuretic Peptide Receptor Activation Inhibits Sodium Channel Activity in Human Aortic Endothelial Cells by Activating the Diacylglycerol-Protein Kinase C Pathway. [PDF]

Int J Mol Sci, 2022
Yu L, Nouri MZ, Liu LP, Bala N, Denslow ND, LaDisa JF, Alli AA.   +6 more
europepmc   +1 more source

Effects of Dapagliflozin on Cardiovascular Outcomes in Patients With Type 2 Diabetes at Risk of Liver Fibrosis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims The fibrosis‐4 (FIB‐4) score is used to identify risk of advanced liver fibrosis. This post hoc analysis investigated its prognostic value for cardiovascular (CV) outcomes and its relevance to the effects of dapagliflozin. Materials and Methods DECLARE‐TIMI 58 was a randomised, placebo‐controlled phase 3 trial investigating dapagliflozin ...
Jan Oscarsson, Monika Huhn, Yunyun Jiang, Ingrid Gause‐Nilsson, Stephen D. Wiviott, Filipe A. Moura, John P. H. Wilding, Simona Cernea, Luc Van Gaal, Avivit Cahn, Deepak L. Bhatt, Peter A. Johansson, C. David Sjöström   +12 more
wiley   +1 more source

Can't Patch Everything: Personalized Medicine for Cell Therapy in Dilated Cardiomyopathy

, 2021
Journal of the American Heart Association, EarlyView.
Andrew Sundin, Wayne Balkan, Joshua M. Hare   +2 more
wiley   +1 more source

Elevated N-terminal pro C-type natriuretic peptide is associated with mortality in patients undergoing transcatheter aortic valve replacement. [PDF]

BMC Cardiovasc Disord, 2022
Hu P, Chen H, Wang LH, Jiang JB, Li JM, Tang MY, Guo YC, Zhu QF, Pu ZX, Lin XP, Ng S, Liu XB, Wang JA.   +12 more
europepmc   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

Endogenous C-type natriuretic peptide offsets the pathogenesis of steatohepatitis, hepatic fibrosis, and portal hypertension. [PDF]

PNAS Nexus
Perez-Ternero C, Li W, Aubdool AA, Goldin RD, Loy J, Devalia K, Alazawi W, Hobbs AJ.   +7 more
europepmc   +1 more source

Immune checkpoint inhibitor cardiomyotoxicity: a case series of five patients and development of a clinical management algorithm

Internal Medicine Journal, EarlyView.
Abstract Immune checkpoint inhibitor (ICI) therapies have revolutionised the management of a range of malignancies. However, the syndrome of ICI induced cardiomyotoxicity, also reported as triple “M” syndrome (myasthenia gravis, myositis and myocarditis) is an unfortunate severe consequence in up to 1%–2% of patients receiving ICI, with an associated ...
S. Z. Xie, J. E. Salem, A. Nagrial, A. Menzies, L. Thomas, S. Ramanathan, L. J. Berglund, S. C. Sasson, A. C. Grey, R. Habib, M. Wong, M. S. Carlino, B. Jeffrey, J. Mo, M. W. Lin   +14 more
wiley   +1 more source

Clinical Prediction Model for Unsuccessful Left Bundle Branch Area Pacing

Journal of Cardiovascular Electrophysiology, EarlyView.
A clinical prediction model based on NIVCD, interventricular septal thickness, and right atrial area enables individualized estimation of unsuccessful LBBAP and may help guide procedural strategy. ABSTRACT Introduction Left bundle branch area pacing (LBBAP) has rapidly become a preferred form of cardiac physiologic pacing; however, predictors of ...
Yousaku Okubo, Junji Maeda, Shogo Miyamoto, Hiroshi Oe, Naoki Ishibashi, Shunsuke Ishida, Takumi Sakai, Naoto Oguri, Motoki Furutani, Shunsuke Miyauchi, Sho Okamura, Takehito Tokuyama, Noboru Oda, Yukiko Nakano   +13 more
wiley   +1 more source

Prognostic factors in dogs with presumed degenerative mitral valve disease attending primary care veterinary practices in the UK [PDF]

, 2018
Club Kennel, Collett D, Dohoo IR, Mallery KF, Royston P, VetCompass   +5 more
core   +2 more sources