Characterization of Heme Uptake Proteins; HtaB, ChtB, and ChtA from Corynebacterium Diphtheriae Approaches to the Reaction of Dechloromonas Aromatica Chlorite Dismutase with Nitrite [PDF]
Heme is a source of iron for many pathogenic bacteria. Corynebacterium diphtheriae, the first protein in the system is HtaA, ChtA, and/or ChtC; heme is transferred to HtaB or ChtB. Heme is then mobilized into the cytosol by the ABC transporter where iron
Odhiambo, Catherine
core +2 more sources
Unraveling the active site cover of coproheme decarboxylase from Listeria monocytogenes
During heme biosynthesis in Gram‐positive bacteria, coproheme decarboxylase (ChdC) catalyzes the conversion of four‐propionate substrate coproheme to the two propionate product heme b. Its active site is universally covered by a flexible linking loop. This study identifies an important histidine residue, which stabilizes the loop in a ChdC homolog.
Nikolaus Falb +4 more
wiley +1 more source
Image_2_Distinct Genomic Features Characterize Two Clades of Corynebacterium diphtheriae: Proposal of Corynebacterium diphtheriae Subsp. diphtheriae Subsp. nov. and Corynebacterium diphtheriae Subsp. lausannense Subsp. nov..TIFF [PDF]
Corynebacterium diphtheriae is the etiological agent of diphtheria, a disease caused by the presence of the diphtheria toxin. However, an increasing number of records report non-toxigenic C. diphtheriae infections. Here, a C.
Angela Koutsokera (288854) +6 more
core +1 more source
Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella +6 more
wiley +1 more source
Diphtheria is caused by a toxigenic bacterium Corynebacterium diphtheria which is being an emerging pathogen in India. Since diphtheria morbidity and mortality continues to be high in the country, the present study aimed to study the molecular ...
Naveen Kumar Devanga Ragupathi +13 more
doaj +1 more source
ABSTRACT Aim To determine the clinico‐demographic profile and predictors of mortality in hospitalised children with diphtheria. Methods This retrospective cohort study included 202 children aged 5–16 years diagnosed with diphtheria per WHO criteria at Lady Reading Hospital, Peshawar, from January 2023 to December 2024. Data on demographics, vaccination
Amir Muhammad +6 more
wiley +1 more source
Interplay Between Infectious Diseases and the Endocrine System: An Overview and Clinical Insights
Infectious diseases can disrupt endocrine homeostasis through direct cytopathic injury, autoimmune dysregulation, or pathogen‐derived hormone‐like effects. Viruses and bacteria are the most frequent agents, whereas fungi and parasites contribute less commonly, even remaining clinically relevant, especially in the immunocompromised population.
Francesco Capoccia +4 more
wiley +1 more source
Molecular epidemiology of
Background The reemergence of epidemic diphtheria in Belarus in 1990s has provided us with important information on the biology of the disease and the diversity of the causative agent Corynebacterium diphtheriae.
Titov, Leonid +17 more
core +1 more source
Non-toxigenic Corynebacterium diphtheriae endocarditis: A cluster of five cases
Background: Classical toxin-mediated respiratory diphtheria has become less common because of widespread effective vaccination globally but invasive disease as a result of non-toxigenic strains of Corynebacterium diphtheriae is not prevented by ...
Tamsin Lovelock +9 more
doaj +1 more source
Topical PL‐5 spray improves clinical outcomes in mild‐to‐moderate infected diabetic foot ulcers and achieves superior pathogen clearance among drug‐resistant infection subgroups. It represents a promising low‐resistance topical option for managing mild to moderate DFU infections.
Li Qian +10 more
wiley +1 more source

