Results 211 to 220 of about 19,786,213 (303)

Structures of the UBR4 complex reveal a giant arena to capture diverse substrates for ubiquitin chain elongation

The FEBS Journal, EarlyView.
This review summarizes recent structures of the UBR4 complex, a giant E4 ubiquitin ligase which recognizes proteins with pre‐existing ubiquitin modifications and marks them for degradation. The UBR4 complex uses a large arena lined with substrate interaction modules to select features on ubiquitinated substrates, such as the presence of N‐degrons or ...
Daniel B. Grabarczyk, Tim Clausen
wiley   +1 more source

A systematic fluorescently tagged protein toolkit for dissecting apical extracellular matrix patterning in C. elegans. [PDF]

PLoS Biol
Ragle JM, Pooranachithra M, Ashley GE, Cadena E, Blank B, Kang K, Chen C, Bhowmick AR, Mercado SH, Wells TE, Clancy JC, Chisholm AD, Ward JD.   +12 more
europepmc   +1 more source

Phosphorylation of BigH1 regulates its expression pattern and promotes embryonic development

The FEBS Journal, EarlyView.
Phosphorylation is a key regulator of the linker histone variant BigH1 during Drosophila embryogenesis. We reveal that N‐terminal phosphorylation promotes the timely removal of BigH1 from chromatin. In contrast, C‐terminal phosphorylation supports early nuclear divisions and embryonic viability.
Ramóna Pék, Aladár Pettkó‐Szandtner, Anikó Szabó, Balázs Vedelek, Bence György Gombás, Zoltán Villányi, Péter Vilmos, Imre Miklós Boros, László Henn, Gyula Timinszky   +9 more
wiley   +1 more source

FLInt 2.0: robust and customizable single-shot integration in C. elegans. [PDF]

G3 (Bethesda)
Malaiwong N, Malaiwong P, Kim C, O'Donnell M.   +3 more
europepmc   +1 more source

Crystal structure of human NIF3‐like protein reveals dynamic hexameric assembly with a single divalent metal binding site

The FEBS Journal, EarlyView.
We present the first crystal structures of human NIF3, revealing a dynamic, hexameric ring with a central cavity regulated by flexible insertion domains. Crucially, human NIF3 features a mononuclear zinc‐binding site, marking a distinct evolutionary departure from the dinuclear centers of bacterial homologs.
Elżbieta Wątor‐Wilk, Krzysztof Żak, Piotr Wilk, Paweł Kochanowski, Agnieszka Maślanka, Łukasz Skalniak, Przemysław Grudnik   +6 more
wiley   +1 more source

Gonad-soma inter-tissue communication alleviates ultraviolet-induced neurotoxicity in C. elegans. [PDF]

Cell Commun Signal
Zhang W, Ding L, Qiao S, Xu J, Yi Q, Liu B, Bian P, Wang T.   +7 more
europepmc   +1 more source

Selective autophagy pathways in ageing and neurodegeneration: Emerging roles for mitophagy and nucleophagy

The FEBS Journal, EarlyView.
As we age, cells gradually accumulate damage, which can contribute to disease and neurodegeneration. This review explores how two cellular recycling processes, mitophagy and nucleophagy, remove damaged mitochondria and nuclear material, respectively, to maintain cell health and long‐term neuronal homeostasis.
Maria Markaki, Nektarios Tavernarakis
wiley   +1 more source

HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in C. elegans. [PDF]

Nucleic Acids Res
Muñoz-Barrera M, Mata-Cabana A, Moreno-Rivero A, Piubeli FA, Ren-Barroso B, Al-Refaie N, Gutierrez G, Cabianca DS, Olmedo M.   +8 more
europepmc   +1 more source

Brief encounters and lasting impressions—How target protein half‐life affects reactive metabolite signaling

The FEBS Journal, EarlyView.
Lipid‐derived reactive electrophile molecules (REMs) are generated from fatty acids through lipoxygenase or cyclooxygenase‐assisted catalysis, or free radical‐induced lipid peroxidation events. REMs so‐produced covalently modify nearby protein‐cysteines, and in the case of ‘first responder’ proteins, can trigger gain‐of‐function signaling with context ...
Marcus J. C. Long, Lorna Birkby, Yimon Aye   +2 more
wiley   +1 more source