Results 211 to 220 of about 18,831,157 (296)

The trimeric Shu complex in C. elegans is an ATPase that remodels RAD51 filaments in the homologous recombination‐associated DNA damage response

The FEBS Journal, EarlyView.
The C. elegans Shu complex (RFS‐1/RIP‐1/SWS‐1) is a DNA‐dependent ATPase that regulates RAD‐51 filaments during homologous recombination. The trimer preferentially binds 5′‐exposed DNA, remodels RAD‐51 filaments via ATP hydrolysis, and stabilizes filaments through ATP binding.
Sam Siu Hang Chu, Guangxin Xing, Kichang Paik, Anton Gartner, Hong Ling   +4 more
wiley   +1 more source

ER-to-Golgi transport machinery promotes the excessive cargo-triggered unfolded protein response in C. elegans. [PDF]

PLoS Genet
Guan L, Zhang T, Zhan Z, Wang Y, Huang X, Ding M.   +5 more
europepmc   +1 more source

Structures of the UBR4 complex reveal a giant arena to capture diverse substrates for ubiquitin chain elongation

The FEBS Journal, EarlyView.
This review summarizes recent structures of the UBR4 complex, a giant E4 ubiquitin ligase which recognizes proteins with pre‐existing ubiquitin modifications and marks them for degradation. The UBR4 complex uses a large arena lined with substrate interaction modules to select features on ubiquitinated substrates, such as the presence of N‐degrons or ...
Daniel B. Grabarczyk, Tim Clausen
wiley   +1 more source

Unrolling worms: Genome Editing to Rewrite Roller Phenotypes in <i>C. elegans</i>. [PDF]

MicroPubl Biol
Mukherjee S, Stavoe AK.
europepmc   +1 more source

Phosphorylation of BigH1 regulates its expression pattern and promotes embryonic development

The FEBS Journal, EarlyView.
Phosphorylation is a key regulator of the linker histone variant BigH1 during Drosophila embryogenesis. We reveal that N‐terminal phosphorylation promotes the timely removal of BigH1 from chromatin. In contrast, C‐terminal phosphorylation supports early nuclear divisions and embryonic viability.
Ramóna Pék, Aladár Pettkó‐Szandtner, Anikó Szabó, Balázs Vedelek, Bence György Gombás, Zoltán Villányi, Péter Vilmos, Imre Miklós Boros, László Henn, Gyula Timinszky   +9 more
wiley   +1 more source

A pcyt-1 allelic series reveals in vivo consequences of reduced phosphatidylcholine synthesis in C. elegans. [PDF]

G3 (Bethesda)
Qvist A, Kaper D, Henricsson M, Stjernman A, Borén J, Pilon M.   +5 more
europepmc   +1 more source

Crystal structure of human NIF3‐like protein reveals dynamic hexameric assembly with a single divalent metal binding site

The FEBS Journal, EarlyView.
We present the first crystal structures of human NIF3, revealing a dynamic, hexameric ring with a central cavity regulated by flexible insertion domains. Crucially, human NIF3 features a mononuclear zinc‐binding site, marking a distinct evolutionary departure from the dinuclear centers of bacterial homologs.
Elżbieta Wątor‐Wilk, Krzysztof Żak, Piotr Wilk, Paweł Kochanowski, Agnieszka Maślanka, Łukasz Skalniak, Przemysław Grudnik   +6 more
wiley   +1 more source

Erratum: Corrigendum: Deguelin promotes longevity and healthspan through <i>C. elegans fmo-4</i>. [PDF]

MicroPubl Biol
europepmc   +1 more source

Autophagy: A Double-Edged Sword in the Aging of <i>C. elegans</i>. [PDF]

Int J Mol Sci
Sigmond T, Barna J.
europepmc   +1 more source

Dragonfly taxonomic and functional responses to urbanized streams in southeastern Europe, with management recommendations

Insect Conservation and Diversity, EarlyView.
Urbanization drives turnover in dragonfly species composition, traits, and habitat conservation value. Natural stream sections have a higher conservation value (higher DBI) due to presence of specialists. Properly managed urban streams can support diverse dragonfly assemblages.
Marina Vilenica, Andreja Brigić, Lea Ružanović, Renata Matoničkin Kepčija, Greet De Knijf, Michael J. Samways   +5 more
wiley   +1 more source