Results 31 to 40 of about 20,378,080 (258)

Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii

open access: yesACS Medicinal Chemistry Letters, 2010
The protozoans Cryptosporidium parvum and Toxoplasma gondii are parasites of major health concern to humans. Both parasites contain a group of calcium-dependent protein kinases (CDPKs), which are found in plants and ciliates but not in humans or fungi ...
R. C. Murphy   +13 more
semanticscholar   +1 more source

Interferon-λ3 Promotes Epithelial Defense and Barrier Function Against Cryptosporidium parvum InfectionSummary

open access: yesCellular and Molecular Gastroenterology and Hepatology, 2019
Background & Aims: The epithelial response is critical for intestinal defense against Cryptosporidium, but is poorly understood. To uncover the host strategy for defense against Cryptosporidium, we examined the transcriptional response of intestinal ...
Sylvia H. Ferguson   +5 more
doaj   +1 more source

Effects of C. parvum on growth and induction of intracerebral tumours in mice [PDF]

open access: yesBritish Journal of Cancer, 1977
An investigation was made into the effect of Corynebacterium parvum therapy on cerebral tumours in mice. I.v. C. parvum caused a slight but significant increase in the survival of BALB/c mice injected intracerebrally (i.c.) with not more than 50 Meth A cells. C. parvum was most effective if given on the same day or 5 days after tumour. If this interval
Osborn, D E, Sadler, T E, Castro, J E
openaire   +2 more sources

The role of atypical MAP kinase 4 in the host interaction with Cryptosporidium parvum

open access: yesScientific Reports, 2023
Cryptosporidium parvum is an apicomplexan parasite that causes severe zoonotic diarrhea in humans and calves. Since there are no effective treatments or vaccines for infants or immunocompromised patients, it is important to understand the molecular ...
Nina Watanabe   +6 more
doaj   +1 more source

MCT-Dependent Cryptosporidium parvum-Induced Bovine Monocyte Extracellular Traps (METs) under Physioxia

open access: yesBiology, 2023
The apicomplexan protozoan parasite Cryptosporidium parvum is responsible for cryptosporidiosis, which is a zoonotic intestinal illness that affects newborn cattle, wild animals, and people all over the world.
Seyed Sajjad Hasheminasab   +5 more
doaj   +1 more source

Further Observations on the Effect of C. parvum and Anti-Tumour Globulin on Syngeneically Transplanted Mouse Tumours

open access: yesBritish Journal of Cancer, 1972
The inhibitory effect of an i.v. or i.p. injection of C. parvum on intrastrain transplants of a mammary carcinoma in A/HeJ mice has been confirmed, and it has been shown further that C.
M. Woodruff, M. Inchley, N. Dunbar
semanticscholar   +1 more source

Prevalence and molecular characterization of Cryptosporidium in goats across four provincial level areas in China. [PDF]

open access: yesPLoS ONE, 2014
This study assessed the prevalence, species and subtypes of Cryptosporidium in goats from Guangdong Province, Hubei Province, Shandong Province, and Shanghai City of China. Six hundred and four fecal samples were collected from twelve goat farms, and the
Rongsheng Mi   +8 more
doaj   +1 more source

Proteome-wide prediction and analysis of the Cryptosporidium parvum protein–protein interaction network through integrative methods

open access: yesComputational and Structural Biotechnology Journal, 2022
As one of the most studied Apicomplexan parasite Cryptosporidium, Cryptosporidium parvum (C. parvum) causes worldwide serious diarrhea disease cryptosporidiosis, which can be deadly to immunodeficiency individuals, newly born children, and animals ...
Panyu Ren   +4 more
doaj   +1 more source

Lymphoproliferative and Cytokine Responses to Cryptosporidium parvum in Patients Coinfected with C. parvum and Human Immunodeficiency Virus [PDF]

open access: yesClinical and Vaccine Immunology, 2009
ABSTRACT We compared the lymphoproliferative and cytokine responses to Cryptosporidium parvum in human immunodeficiency virus (HIV)-seropositive and -seronegative patients. The lymphoproliferative and cytokine responses (interleukin-2 [IL-2], IL-4, IL-5, IL-10, gamma interferon, and tumor necrosis factor ...
Kirti, Kaushik   +3 more
openaire   +2 more sources

Microbiota-produced indole metabolites disrupt mitochondrial function and inhibit Cryptosporidium parvum growth

open access: yesCell Reports, 2023
SUMMARY Cryptosporidiosis is a leading cause of life-threatening diarrhea in young children in resource-poor settings. To explore microbial influences on susceptibility, we screened 85 microbiota-associated metabolites for their effects on ...
Lisa J. Funkhouser-Jones   +11 more
semanticscholar   +1 more source

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