Results 161 to 170 of about 2,333,240 (283)

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Novel Substituted Indazoles as Small Molecule-Based Inhibitors of KRAS Proteins. [PDF]

ACS Med Chem Lett
Rong J, Liang SH.
europepmc   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Syntheses and crystal structures of di-chlorido-(2,6-di-methyl-pyrazine-κ<i>N</i>)(methanol-κ<i>O</i>)zinc(II), di-bromido-(2,6-di-methyl-pyrazine-κ<i>N</i>)(methanol-κ<i>O</i>)zinc(II) and aqua-(2,6-di-methyl-pyrazine-κ<i>N</i>)di-iodido-zinc(II). [PDF]

Acta Crystallogr E Crystallogr Commun
Näther C.
europepmc   +1 more source

Hierarchical Summary Statistics Encoding Across Primary Visual and Posterior Parietal Cortices

Advanced Science, EarlyView.
This study shows that mouse V1 simultaneously encodes the ensemble mean and variance of motion, providing a robust summary‐statistic representation that persists despite single‐neuron variability. These signals propagate to PPC, where they are transformed into abstract category representations during decision making.
Young‐Beom Lee, Oliver James, Gaeun Jung, Doyun Lee, Yee‐Joon Kim   +4 more
wiley   +1 more source

Response to: “Does ACPA-negative RA consist of subgroups related to sustained DMARD-free remission and serological markers at disease presentation” by Masi and Fleischmann

Arthritis Research & Therapy, 2020
Debbie M. Boeters, Annette H. M. van der Helm–van Mil   +1 more
doaj   +1 more source

Effect of alkyl chain length on the corrosion inhibition performance of 2-thioxo-2,3-dihydroquinazolin-4(1H)-one derivatives for carbon steel in HCl solution. [PDF]

Sci Rep
El-Maksoud SAA, Fathalla W, Saleh MS, El-Dossoki FI.   +3 more
europepmc   +1 more source

C1-Esterase [PDF]

, 2017
Harald Renz, Birgit Gierten
openaire   +1 more source

The Uppsala APP Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo

Advanced Science, EarlyView.
We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Junyue Ge, María Pagnon de la Vega, Silvia Zampar, Enrica Cerilli, Srinivas Koutarapu, Ling Wu, Paul Fraser, Sertan Arkan, Vilmantas Giedraitis, Lars Lannfelt, Greta Hultqvist, Stina Syvänen, Martin Ingelsson, Jörg Hanrieder, Dag Sehlin   +14 more
wiley   +1 more source

Crystal structure, spectroscopic characterization, and Hirshfeld surface analysis of (<i>E</i>)-6-(ferrocenylmethyl-idene)-6,7-di-hydro-5<i>H</i>-indeno-[5,6-<i>d</i>][1,3]dioxol-5-one. [PDF]

Acta Crystallogr E Crystallogr Commun
Méndez-Román JA, Burgos-Suazo A, Santiago-Martoral LN, Piñero Cruz DM, Montes-González I.   +4 more
europepmc   +1 more source