Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
The persistent proatlantal artery: types and subtypes. [PDF]
Rusu MC, Tudose RC, Vrapciu AD.
europepmc +1 more source
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He +10 more
wiley +1 more source
Study of the Molecular-Weight Distribution of Binder Pitches for Carbon Blocks
Jong Hoon Cho, Min Il Kim, Ji Sun Im
doaj +1 more source
Crystal structure and Hirshfeld surface analysis of ethyl 2-amino-4-(4-chloro-phen-yl)-5,6,7,8,9,10-hexa-hydro-cyclo-octa-[<i>b</i>]pyridine-3-carboxyl-ate. [PDF]
Pazhamalai S +4 more
europepmc +1 more source
This work paves the way for practical photoelectrochemical water splitting devices by addressing key upscaling challenges related to substrate conductivity, absorber inhomogeneity, and mass transfer limitations. Integrated improvements in substrate engineering, material processing, device architecture, and operational conditions allow the development ...
Telmo da Silva Lopes +7 more
wiley +1 more source
Readout and delayed transmission of initial afferent V1 activity in decisions about stimulus contrast. [PDF]
Mohr KS, Kelly SP.
europepmc +1 more source
Halofuginone is a Molecular Glue Degrader of Integrin β4
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong +8 more
wiley +1 more source
Syntheses and crystal structures of bis-(2,3-di-methyl-pyrazine-κ<i>N</i>)di-iodido-cadmium(II) and <i>catena</i>-poly[[di-iodido-cadmium(II)]-μ-2,3-di-methyl-pyrazine-κ<sup>2</sup> <i>N</i> <sup>1</sup>:<i>N</i> <sup>4</sup>]. [PDF]
Näther C.
europepmc +1 more source

