Results 221 to 230 of about 575,689 (289)

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

Case Report: Multimodal imaging, custom 3D-printed reconstruction and surgical stabilization of severe congenital occipitoatlantoaxial malformation in an adult dog. [PDF]

Front Vet Sci
Pinal KM, DiRubio ML, Zidan N, Loeber S, Cameron S.   +4 more
europepmc   +1 more source

Retinomorphic Visual Processing Enabled by Contact‐Engineered IGZO Optoelectronic Synaptic Memtransistors

Advanced Science, EarlyView.
Here, we present an optoelectronic synaptic memtransistor (OSMT) integrating photoresponsive IGZO with contact‐engineered HfO2, enabling electrically and optically tunable synaptic weights. The device demonstrates broad range of tunable conductance states and array‐level image processing, highlighting its potential for intelligent machine vision ...
Donghyun Kang, San Nam, Dayul Nam, In‐Soo Kim, Myung‐Gil Kim, Sung Kyu Park, Yong‐Hoon Kim   +6 more
wiley   +1 more source

Unilateral High-Riding Vertebral Artery Associates With the Progression of Atlantoaxial Joint Degeneration in Patients With Rheumatoid Arthritis. [PDF]

Int J Rheum Dis
Murata K, Fujii T, Otsuki B, Shimizu T, Sono T, Onishi A, Nakabo S, Murakami K, Tanaka M, Morinobu A, Matsuda S.   +10 more
europepmc   +1 more source

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

Distal internal carotid artery dissection after carotid endarterectomy for a high cervical lesion suggesting an Eagle-like mechanism of shunt-related injury: illustrative case. [PDF]

J Neurosurg Case Lessons
Ito K, Kamijo E, Kushi K, Mochizuki T, Nonaka T, Ryu B, Sato S, Inoue T, Tsutsumi Y, Niimi Y, Kawashima A.   +10 more
europepmc   +1 more source

Super‐Resolution and High‐Data‐Density Acoustic Meta‐Hologram via Amplitude and Phase Coupling

Advanced Science, EarlyView.
A super‐resolution acoustic meta‐hologram utilizes amplitude‐phase coupling under energy conservation constraints to overcome the traditional diffraction limit. This conceptually advanced approach achieves high‐fidelity acoustic field reconstruction and dense information transmission, unlocking new potentials for high‐resolution acoustic imaging and ...
Xiao Guo, Xinzong Wang, Guoshen Tang, Haohan Zeng, Siqi Fan, Xinghao Hu, Youyu Mo, Zhenyu He, Tingting Li, Hui Xu, Jiao Shen, Haiyan Fan, Xiaoxiang Gao, Yifan Zhu, Hui Zhang, Badreddine Assouar   +15 more
wiley   +1 more source

In silico discovery of CETP inhibitors from ZINC15 compounds using docking, ADMET filtering, and molecular dynamics simulations. [PDF]

Res Pharm Sci
Mohammadi K, Nejabat M, Mirabi F, Sahebkar A, Hadizadeh F.   +4 more
europepmc   +1 more source

Recent Advances in Carbon Cathode Materials toward High‐Performing Zinc‐Ion Hybrid Supercapacitors

Advanced Science, EarlyView.
Aqueous zinc‐ion hybrid supercapacitors (ZHSCs) have emerged as promising next‐generation electrochemical energy‐storage devices. Porous carbon materials have been extensively studied as cathodes, with advances in tailoring pore structures and material properties to enhance performance.
Take Hirooka, Zhaolin Liu, Ivan P. Parkin, Guanjie He   +3 more
wiley   +1 more source

A bioinformatics analysis of KIF transcriptomic subtyping reveals prognostic heterogeneity and differential therapeutic responses in cervical cancer. [PDF]

Oncol Lett
Zhao X, Wu J, Li L, Zhang H, Li J, Zhong H, Dan Y, Song Q, Chen H, Xu B.   +9 more
europepmc   +1 more source