Results 41 to 50 of about 595,845 (281)

Acquired C1 inhibitor (C1-INH) deficiency type II. Replacement therapy with C1-INH and analysis of patients' C1-INH and anti-C1-INH autoantibodies. [PDF]

Journal of Clinical Investigation, 1989
The response of two patients with autoantibody-mediated C1-inhibitor (C1-INH) deficiency to replacement therapy with C1-INH was studied over a period of 3 d. In patient 1 an acute attack of angioedema was successfully managed by infusion of 1,000 U of C1-INH concentrate.
J, Alsenz, J D, Lambris, K, Bork, M, Loos   +3 more
openaire   +2 more sources

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Correcting streamflow bias considering its spatial structure for impact assessment of climate change on floods using d4PDF in the Chao Phraya River Basin, Thailand

Journal of Hydrology: Regional Studies, 2022
Study region: Chao Phraya River Basin (CPRB), the predominant basin located in Thailand. Study focus: This study aims to ascertain the difference between spatial bias heterogeneity of streamflow in large river basins such as CPRB for a robust analysis ...
Aakanchya Budhathoki, Tomohiro Tanaka, Yasuto Tachikawa   +2 more
doaj   +1 more source

C1 exists in 2 stereoisomers.

, 2023
a) C1’s structure inherits 2 stereo centres, both located in the backbone of the peptide bonds, one in the amino acid proline (shown in blue) and the other one in the amino acid phenylglycine (shown in red).
Jens Peter von Kries (4059484), Amanda Costa (14573424), Sabrina Kleissle (14573433), Kevin Stuke (14573436), Philipp Jordan (9364068), Susanne A. Wolf (14573442), Helmut Kettenmann (214707), Martin Neuenschwander (680771), Phillip Mertins (14573439), Regina Piske (14573427), Tessa Obrusnik (14573430), Marc Nazare (1634590), Edgar Specker (2140024), Oliver Popp (153407), Andrea Volkamer (1444000), Andre Rex (2623558)   +15 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Characterization of cell wall degrading enzymes from Chrysosporium lucknowense C1 and their use to degrade sugar beet pulp [PDF]

, 2011
Key words: Pectin, arabinan, biorefinery, mode of action, branched arabinose oligomers, ferulic acid esterase, arabinohydrolase, pretreatment Sugar beet pulp is the cellulose and pectin-rich debris remaining after sugar extraction from sugar beets.
Kühnel, S.
core  

Plasma levels of C1- inhibitor complexes and cleaved C1- inhibitor in patients with hereditary angioneurotic edema [PDF]

, 1990
C1- inhibitor (C1(-)-Inh) catabolism in plasma of patients with hereditary angioneurotic edema (HANE) was assessed by measuring the complexes formed by C1(-)-Inh with its target proteases (C1-s, Factor XIIa, and kallikrein) and a modified (cleaved ...
M Cugno, M. Cicardi, D. Frangi, A. Eerenberg, A. Agostoni, D Frangi, A Agostoni, E. Hack, M Cicardi, M. Cugno, A Eerenberg, J. Nuijens, J Nuijens, E Hack   +13 more
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Endoscopic Transnasal Approach for Urgent Decompression of the Craniocervical Junction in Acute Skull Base Osteomyelitis

Journal of Neurological Surgery Reports, 2015
Ventral epidural abscess with osteomyelitis at the craniocervical junction is a rare occurrence that typically mandates spinal cord decompression via a transoral approach.
Terry C. Burns, Stefan A. Mindea, Arjun V. Pendharkar, Nicolae B. Lapustea, Ioana Irime, Jayakar V. Nayak   +5 more
doaj   +1 more source