Results 41 to 50 of about 432,899 (199)

Correcting streamflow bias considering its spatial structure for impact assessment of climate change on floods using d4PDF in the Chao Phraya River Basin, Thailand

Journal of Hydrology: Regional Studies, 2022
Study region: Chao Phraya River Basin (CPRB), the predominant basin located in Thailand. Study focus: This study aims to ascertain the difference between spatial bias heterogeneity of streamflow in large river basins such as CPRB for a robust analysis ...
Aakanchya Budhathoki, Tomohiro Tanaka, Yasuto Tachikawa   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Assessing extreme flood inundation and demographic exposure in climate change using large ensemble climate simulation data in the Lower Chao Phraya River Basin of Thailand

Journal of Hydrology: Regional Studies, 2023
Study region: Lower Chao Phraya River Basin (LCPRB), Thailand. Study focus: This study aims to make a robust assessment based on a large ensemble d4PDF dataset and a flood-inundation model Inundation Model Coupling Rainfall-runoff (IMCR) for the LCPRB ...
Aakanchya Budhathoki, Tomohiro Tanaka, Yasuto Tachikawa   +2 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

C1–C2 Transarticular Screw with Sublaminar Wiring for Reducible Atlantoaxial Dislocation: Operative Technique and Surgical Nuances

Journal of Spinal Surgery
Transarticular screw provides rigid C1 C2 fixation. It is associated with robust implant construct and high fusion rates. Combining sublaminar wiring provides rigid three point fixation.
T. P. Waseem Ahamed, Ashutosh Kumar, Abhishek Shukla, Vandan Raiyani, Sudhir Bisan Sasapardhi, Kamlesh Singh Bhaisora, Arun Kumar Srivastava, Raj Kumar   +7 more
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

International financial support to achieve the net-zero emissions goal could help resolve equity trade-off between developing and developed countries

Communications Earth & Environment
Over 100 countries have announced net-zero emissions goals. Although these net-zero emissions goals may be consistent with global 2 °C climate stabilization, their impacts on equity between developing and developed regions remain poorly understood. Here,
Shinichiro Fujimori, Limeng Fan, Shiya Zhao, Shinichiro Asayama, Tomoko Hasegawa, Osamu Nishiura, Hiroto Shiraki, Kiyoshi Takahashi   +7 more
doaj   +1 more source