Results 201 to 210 of about 312,656 (329)

Intranasal delivery of FSD‐C10, a novel Rho kinase inhibitor, exhibits therapeutic potential in experimental autoimmune encephalomyelitis

Immunology, 2014
Yan‐hua Li, Jie Yu, Chun-yun Liu, Hui Zhang, Hai-fei Zhang, Wan‐Fang Yang, Junlian Li, Q. Feng, Ling Feng, Guang-Xian Zhang, B. Xiao, Cun-Gen Ma   +11 more
semanticscholar   +1 more source

Artificial lipidation of proteins and peptides: from mechanism to clinical applications

The FEBS Journal, EarlyView.
Artificial lipidation transforms protein and peptide therapeutics by attaching fatty acid chains through reversible or permanent chemical strategies. This biomimetic approach delivers four key therapeutic advantages: extended circulation times (enabling weekly instead of daily dosing), alternative administration routes including oral delivery, precise ...
Jiaming Mu, Emily Vong, Sheiliza Carmali
wiley   +1 more source

Nanocrystal Synthesis Derived Approach to Silver Bismuth Iodide Layered Double Perovskites with Aliphatic Amines: (C <i>_n</i> H_{(2<i>n</i>+1)}NH₃)₄AgBiI₈. [PDF]

Chem Mater
Rusch P, Antony AM, Pegu M, Jabrane M, Saleh G, Garai A, Asaithambi A, Lauciello S, Marras S, De Negri S, Solokha P, Manna L.   +11 more
europepmc   +1 more source

Expanding the substrate scope of a bacterial monoterpene synthase for the production of sesquiterpenoid and diterpenoid products

The FEBS Journal, EarlyView.
We have converted the only known true bacterial monoterpene synthase, cineole synthase from Streptomyces clavuligerus (bCinS, C10 substrate), to a highly competent sesquiterpene synthase (C15) with a minimum number of rational mutations. By comparison with diterpene synthases (C20), we were then able to bestow diterpene synthase activity on bCinS. This
Nicole G. H. Leferink, Joshua N. Whitehead, Linus O. Johannissen, Nigel S. Scrutton   +3 more
wiley   +1 more source

Homeobox Protein Hox-C10 [PDF]

, 2020
openaire   +1 more source

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, EarlyView.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source

Assessment of the potential contribution of the highly conserved C-terminal motif (C10) of Borrelia burgdorferi outer surface protein C in transmission and infectivity.

Pathogens and Disease, 2014
C. Earnhart, D. Rhodes, Alexis A. Smith, Xiuli Yang, Brittney K. Tegels, J. Carlyon, U. Pal, R. Marconi   +7 more
semanticscholar   +1 more source

Effect of Moderate Heat on TCE Reductive Dechlorination Rates in Groundwater

Groundwater Monitoring &Remediation, EarlyView.
Abstract Low‐temperature heating (in the mesophilic range of ~15 to 40 °C) of contaminated aquifers offers the prospect of increasing the rates for biotic and abiotic treatment of volatile organic compounds. Thermal In Situ Sustainable Remediation (TISR®) is one of the approaches available to implement low temperature heating.
David L. Freedman, Nicholas Cotter, Craig Divine, Shandra Justicia‐Leone   +3 more
wiley   +1 more source

Cosmetic creams with caprylic acid‐based Natural Eutectic Solvents: Stability, rheology and user perception

International Journal of Cosmetic Science, EarlyView.
By formulating creams with caprylic acid‐based hydrophobic Natural Eutectic Solvents and assessing their stability, rheological behaviour and sensory properties, this study demonstrates how these systems can act as multifunctional, COSMOS‐compliant ingredients that modulate emulsion characteristics without compromising formulation properties.
Alexis Verger, Roxane Grard, Charlotte Pradel, Xavier Perse, Salima Bouderbala, Alexandra Despres, Leslie Boudesocque‐Delaye, Emilie Munnier   +7 more
wiley   +1 more source