Results 121 to 130 of about 77,699 (297)

Intermolecular Carbon–Carbon Naphthalene Coupling Involves a Radical Mechanism Driven by Cytochrome P450 in Alternaria alternata

Angewandte Chemie, EarlyView.
1,8‐DHN is an important intermediate to form complex aromatic ring systems. Phenol‐coupling reactions are important for the dimerization of two molecules. Here, we show that a fungal cytochrome P450 enzyme catalyzes specific C─C bonds. ABSTRACT Dihydroxynaphthalene (DHN) derivatives are precursors of biologically important molecules, including melanin ...
Jia Gao, Leyao Chen, Karin Steffen, Henrik Schweder, Birgit Schreckenberger, Shu‐Ming Li, Ben Auxier, Antonis Rokas, Reinhard Fischer   +8 more
wiley   +2 more sources

Nanocatalytic Immunotherapy Targeting Tumor‐Resident Intracellular Bacteria for Triple‐Negative Breast Cancer Treatment and Metastasis Suppression

Advanced Science, EarlyView.
Bacteria residing within tumor cells contribute to breast cancer progression, but few therapies target their elimination. FeSe2 nanosheets coated with cancer cell membranes accumulate in tumors and generate reactive oxygen species under ultrasound, killing tumor cells and their harbored bacteria at the same time.
Xiaojing Leng, Tao Jiang, Zhao Guo, Zhimin Zhang, Yihan Chen, Pan Li, Min Ge, Han Lin, Liang Zhang   +8 more
wiley   +1 more source

Residues on MOD that correspond to the C11-P interacting residues on TCS.

, 2012
A) Superimposed structures of MOD (pdb: 2PQI) and TCS-C11-P complex (pdb: 2JDL). The beta strands β7 and β8 in TCS (wheat) are replaced by the helix αI in MOD (cyan) while helices αG and αJ are conserved.
Kam-Bo Wong (28485), Pang-Chui Shaw (28484), Kong-Hung Sze (28482), Yiu-Ming Ng (112621), Yuen-Ting Wong (112619), Amanda Nga-Sze Mak (112623)   +5 more
core   +1 more source

QUANTUM-CHEMICAL STUDY OF THE STRUCTURE AND PROPERTIES OF MOLECULE OF THE LUPININE ALKALOID DERIVATIVE

Eurasian Physical Technical Journal
The paper presents the results of a quantum-chemical study of the molecule 1-((4-(3-methoxyphenyl)-1H-1,2,3-triazol-1-yl) methyl) octahydro-1H-quinolizine. The geometrical characteristics of this molecule obtained from quantum-chemical calculations have
K.B. Kopbalina, A.S. Makhmutova, D.M. Turdybekov, K.M. Turdybekov, G.K. Tolenova   +4 more
doaj   +1 more source

Updatable Closed‐Form Evaluation of Arbitrarily Complex Multiport Network Connections

Advanced Electronic Materials, EarlyView.
The inverse design of electrically large wave devices often uses reduced‐order multiport models with discrete optimization, requiring many evaluations of complex interconnections between subsystems that differ only in a few blocks. This paper introduces a closed‐form framework enabling efficient Woodbury low‐rank updates of related, previous ...
Hugo Prod'homme, Philipp del Hougne
wiley   +1 more source

Phytohormone and energy metabolism of rice germination and coleoptile growth during submergence by RNA-seq and LC-MS/MS analysis

Plant Stress
Rice is one of the main food crops to guarantee the world's food security. Although rice is a semi-aquatic crop, long-term flooding stress can also inhibit growth and reduce yield and quality.
Qi Du, Tuo Zou, Shuo Wang, Lingqi Meng, Wei Zhang, Leiyue Geng   +5 more
doaj   +1 more source

A Unifying Approach to Self‐Organizing Systems Interacting via Conservation Laws

Advanced Intelligent Discovery, EarlyView.
The article develops a unified way to model and analyze self‐organizing systems whose interactions are constrained by conservation laws. It represents physical/biological/engineered networks as graphs and builds projection operators (from incidence/cycle structure) that enforce those constraints and decompose network variables into constrained versus ...
F. Barrows, G. Zhang, S. Anand, Z. Chen, J. Lin, A. Desai, S. Martiniani, F. Caravelli   +7 more
wiley   +1 more source

A positive allosteric modulator of the β1AR with antagonist activity for catecholaminergic polymorphic ventricular tachycardia

The Journal of Clinical Investigation
Orthosteric beta blockers represent the leading pharmacological intervention for managing heart diseases owing to their ability to competitively antagonize β-adrenergic receptors (βARs).
Alyssa Grogan, Robin M. Perelli, Seungkirl Ahn, Haoran Jiang, Arun Jyothidasan, Damini Sood, Chongzhao You, David I. Israel, Alex Shaginian, Qiuxia Chen, Jian Liu, Jialu Wang, Jan Steyaert, Alem W. Kahsai, Andrew P. Landstrom, Robert J. Lefkowitz, Howard A. Rockman   +16 more
doaj   +1 more source

Generative and Experimental Validation of High Refractive Index Polymers via Domain Knowledge Approach with Small Data

Advanced Intelligent Discovery, EarlyView.
This research demonstrates that the combination of domain knowledge–based multiple regression, multi‐objective Bayesian optimization, and generative models is a suitable prediction tool for candidates of high refractive index polymers, even with the constraints in the model trained on limited data. The experimental validation can reproduce the proposed
Takuya Yokoo, Seigo Watanabe, Hana Matsunaga, Kenichi Oyaizu   +3 more
wiley   +1 more source

Deciphering the nature and statistical optimization of antimicrobial metabolites of two endophytic bacilli

AMB Express
In this study, Allium sativum, garlic, was selected to isolate endophytic bacteria and to evaluate the antimicrobial, antiviral, antioxidant, and cytotoxic activities of their produced metabolites followed by identification of the biosynthetic gene ...
Raghda S. Isleem, Ahmed M. Eid, Saad El-Din Hassan, Khaled M. Aboshanab, Ghadir S. El-Housseiny   +4 more
doaj   +1 more source