Results 111 to 120 of about 77,699 (297)

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source

Owicki-Gries Reasoning for C11 Programs with Relaxed Dependencies [PDF]

Deductive verification techniques for C11 programs have advanced significantly in recent years with the development of operational semantics and associated logics for increasingly large fragments of C11.
Dongol, B, Wright, Daniel, Batty, Mark
core  

ALDH2 Suppresses Ferroptosis and Promotes Bortezomib Resistance in Multiple Myeloma Through the KEAP1‐NRF2 Feedback Loop

Advanced Science, EarlyView.
ALDH2, which is overexpressed in multiple myeloma, competitively binds KEAP1 to stabilize NRF2 by blocking its ubiquitin‐proteasomal degradation. Stabilized NRF2 translocates into the nucleus to upregulate the expression of GPX4. In parallel, NRF2 binds to the ALDH2 promoter to regulate its transcription, forming a positive feedback loop that represses
Ruonan Shao, Chengcheng Liu, Xinpei Deng, Jindong Xie, Wenjian Liu, Bin Yang, Lingrui Liu, Cailu Song, Lei Li, Hua Wang, Hailin Tang   +10 more
wiley   +1 more source

Stereoconvergent synthesis of the C1-C11 and C12-C24 fragments of (−)-macrolactin-A

, 2008
Stereoconvergent syntheses of the C1-C11 and C12-C24 fragments of (−)-macrolactin-A are ...
Raj Kumar, M., Yadav, J. S., Sabitha, G.
core   +1 more source

Lithium‐Doped Hydroxyapatite Nanowires Rejuvenate Senescent Macrophages Via the Lysosome‐Dependent Ferroptosis Axis to Promote Aged Bone Regeneration

Advanced Science, EarlyView.
Li‐nHAP+GelMA promotes mandibular bone regeneration in aged mice by remodeling the senescent immune microenvironment. Local delivery of Li‐nHAP restores lysosomal homeostasis in senescent macrophages, reduces intracellular labile Fe2+ accumulation, ROS production, and lipid peroxidation, thereby suppressing macrophage ferroptosis and senescence ...
Baixi Chen, Ziduan Ding, Ruomei Li, Cheng Zhu, Zhiyu Zhu, Zitong Yang, Luyao Qu, Jin Hao, Lunguo Xia, Bing Fang, Lu Liu   +10 more
wiley   +1 more source

Model Studies Toward the Synthesis of Macrolactin A: Organoiron Methodology for Introduction of the C1–C11 and C16–C24 Segments

, 1994
Preparation of the Fe(CO)3 complexed C1–C11 and the C16–C24 segments of macrolactin A has been accomplished from (sorbaldehyde)Fe(CO)3 in 4 steps and 5 steps respectively.
Dennis W. Bennett, Zhi Wang, Wang, Zhi, William A. Donaldson, Donaldson, William A., Peter T. Bell, Bennett, Dennis W, Bell, Peter Thomas   +7 more
core   +1 more source

Advances in Josephson Junction Materials and Processes Toward Practical Quantum Computing

Advanced Science, EarlyView.
Emerging materials for quantum computing, including crystalline materials, two‐dimensional van der Waals materials, two‐dimensional electron gas systems, ferromagnets, and unconventional (e.g., d‐wave) superconductors, offer opportunities to engineer next‐generation Josephson junctions.
Hyunseong Kim, Gyunghyun Jang, Seungwon Jin, Jaewon An, Dongbin Shin, Hyeon‐Jin Shin, Jie Luo, Akel Hashim, Irfan Siddiqi, Yosep Kim, Long B. Nguyen, Hoon Hahn Yoon   +11 more
wiley   +1 more source

PIAS3 CircRNA‐Loaded Lipid Nanoparticles Restore ALOX15 SUMOylation to Suppress Cementoblast Ferroptosis and Attenuate Orthodontically Induced Root Resorption

Advanced Science, EarlyView.
Orthodontic compression suppresses PIAS3 expression in cementoblasts, impairing ALOX15 SUMOylation and ubiquitin‐mediated degradation, which leads to ALOX15 accumulation, lipid peroxidation, ferroptosis, and osteoclastogenesis. Local delivery of PIAS3 circRNA‐loaded lipid nanoparticles restores the PIAS3–ALOX15 regulatory pathway, alleviates ...
Yifei Hou, Chongzheng Yan, Xinrui Xu, Zihan Yang, Xinhui Wu, Hongxu Zhao, Xuan Song, Jianing Zhang, Yijing Li, Aohua Yang, Xiamei Lu, Yi Liu   +11 more
wiley   +1 more source

Synthesis of C1-C11 fragment of callystatin A

, 2015
We wish to describe here our continuing efforts towards the total synthesis of the marine sponge polyketide callystatin A, describing the synthesis of the C1-C11 fragment. (C) 2002 Elsevier Science Ltd.
Meira, PRR, Dias, LC
core   +1 more source

NDT-C11 as a Viable Novel Detergent for Single Particle Cryo-EM [PDF]

Single particle cryo electron microscopy (cryo-EM) is now the major method for the determination of integral membrane protein structure. For the success of a given project the type of membrane mimetic used for extraction from the native cell membrane ...
Jiko, Chimari, Gopalasingam, C., Chai, Chae, Seok, Pil, Moon, Youngsun, Shigematsu, Hideki, Gerle, Christoph, Tanaka, Yoshito, Li, Jiannan, Kurisu, Genji   +8 more
core   +1 more source