Results 211 to 220 of about 265,300 (270)

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, EarlyView.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source

2-(4-Chloro-phen-yl)-1,3-dioxane - localization of hydrogen atoms. [PDF]

IUCrdata
Hosten EC, Betz R.
europepmc   +1 more source

Sinfonie (GS C11)

, 2021
openaire   +1 more source

Demand Shocks, Export Diversification, and Firm Performance During the Great Trade Collapse

Journal of Economics &Management Strategy, EarlyView.
ABSTRACT This paper analyzes the impact of external demand shocks from the 2008 to 2009 Great Trade Collapse on the performance of Chinese exporters and examines how export diversification mitigates these effects. Using Chinese Customs data merged with financial data from all listed Chinese firms, we construct firm‐specific demand shocks based on pre ...
Qianlin Hong, Zeyang Jin, Runjuan Liu, Jiadong Tong   +3 more
wiley   +1 more source

1-(4-Methyl-benzene-sulfon-yl)-1-phenyl-1<i>H</i>,2<i>H</i>-cyclo-buta[<i>c</i>]quinoline. [PDF]

IUCrdata
Schollmeyer D, Dassonneville B, Detert H.   +2 more
europepmc   +1 more source

IL‐15 Plus Thymosin α1 Reduces Senescent Hepatic CD8+ T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression

Journal of Gastroenterology and Hepatology, EarlyView.
Combined IL‐15 and thymosin α1 therapy reverses CD8+ T cell senescence in hepatocellular carcinoma via a “supply and boost” strategy. Tα1 restores thymic naïve T cell output, while IL‐15 enhances peripheral effector function. Mechanistically, this combination suppresses overactivated PI3K/AKT signaling, restoring antitumor immunity and prolonging ...
Fengtian Wu, Zixuan Guo, Jun Guan, Jia Xu, Yao Chen, Zhi Chen   +5 more
wiley   +1 more source

5-Cyclo-hexyl-1,3-diphenyl-1,3,5-di-aza-phosphinane, its phosphine oxide, and its [NiCl₂ <i>L</i> ₂] complex. [PDF]

Acta Crystallogr E Crystallogr Commun
Esjornson D, Anderson D, Vo J, Krause JA, Hubin TJ, Oliver AG.   +5 more
europepmc   +1 more source

A century of vitamin E research: The innovative journey from basic biology to synthetic bio‐manufacturing

Journal of Integrative Plant Biology, EarlyView.
For a century, Vitamin E has been studied for its health benefits. This review traces its journey from basic biological discovery, and the recent identification of its link to chlorophyll degradation, to the modern era of sustainable microbial manufacturing, highlighting the innovative technologies that define its future production.
Ruiqi Zhang, Yuqing Ren, Yuehe Zhao, Hongyan Zheng, Yanzhong Luo, Yuan Liu, Lei Wang, Lan Zhang   +7 more
wiley   +1 more source

Crystal structure and Hirshfeld surface analysis of anhydrous salt of levofloxacin and 4-methyl-benzoic acid. [PDF]

Acta Crystallogr E Crystallogr Commun
Patel BC, Modi KM, Reddy JP.
europepmc   +1 more source

Enhancing CRISPR‐Cas12a base editing in plants with LbCas12a variants and introns

Journal of Integrative Plant Biology, EarlyView.
Intron optimization of LbCas12a‐RRV improves cytosine and adenine base editing efficiency in plants, supports multiplexed and double‐strand break‐free genome modification, and expands precise genome engineering tools for crop breeding and plant functional research. ABSTRACT Cytosine base editors (CBEs) and adenine base editors (ABEs) are powerful tools
Yanhao Cheng, Gen Li, Man Zhou, Rushil Mandlik, Doris Wang, Yiping Qi   +5 more
wiley   +1 more source