Results 151 to 160 of about 118,363 (297)
Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema
Allergy, EarlyView.This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery +25 more
wiley +1 more source
C5 - C15 hydrocarbons in surface sediments from the Bransfield Strait, Antarctica [PDF]
, 1996 This paper deals with the results of composition C5 - C15 hydrocarbons in the regions of the Bransfield Strait. The multivariate statistical analysis is made to recognize the characteristics of the sediments, resulting in the C5 - C15 hydrocarbons ...
Jiazhen, Jiang +3 more
core
KPNA2 Drives Immunosuppression in Ovarian Cancer via CCL2/CCR2‐Dependent MDSC Recruitment
Cancer Science, EarlyView.KPNA2 drives intratumoral MDSC accumulation and immunosuppression in ovarian cancer via the NF‐κB/CCL2/CCR2 axis. Mechanistically, KPNA2 facilitates NF‐κB/p65 nuclear translocation and induces CCL2 transcription, recruiting MDSCs to establish an immunosuppressive microenvironment.
Qingli Li +8 more
wiley +1 more source
Phase stability and elastic properties of C15 compounds HfV{sub 2}+Nb
, 1994 The ternary phase diagram of Hf-V-Nb system has been established and the C15 and C14 Laves phase regions located. The structural stability of the cubic Laves phase HfV{sub 2}+Nb was examined using heat capacity measurements and transmission electron ...
Chu, F., Pope, D. P., Mitchell, T. E.
core
ReTrace: Interactive Visualizations for Reasoning Traces of Large Reasoning Models
Computer Graphics Forum, EarlyView.Abstract Recent advances in Large Language Models have led to Large Reasoning Models, which produce step‐by‐step reasoning traces. Such traces may offer insight into how models think, improving explainability and clarifying the underlying process. These traces, however, are often verbose and complex, making them cognitively demanding to comprehend ...
L. Felder +4 more
wiley +1 more source
Cytopathology, EarlyView.Freezer‐based decoverslipping of archival cytology aspirate smears achieved only 32.5% slide‐level success (26/80), with mounting medium composition and coverslip material, not freezing temperature or duration, identified as dominant determinants, underscoring the need to align coverslipping practices with anticipated ancillary testing requirements ...
Nyein Nyein Htun +3 more
wiley +1 more source
Economic Inquiry, Volume 63, Issue 2, Page 403-423, April 2025.Abstract This paper replicates the study “A Model of Secular Stagnation: Theory and Quantitative Evaluation” by Eggertsson et al. using the Dynare toolkit. Replication is important as it confirms the results of the original article, provides a user‐friendly version using Dynare, and shows how to deal with large‐scale models with occasionally binding ...
Alex Crescentini, Federico Giri
wiley +1 more source
European Management Review, EarlyView.Abstract Corporate purpose is gaining momentum in contemporary business communities, yet it often appears shrouded in ambiguity. Although research is growing in popularity, the analysis of corporate purpose from the perspective of strategic leaders remains an unexplored domain.
Chiara Pantalena +3 more
wiley +1 more source
The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1
The FEBS Journal, EarlyView.ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu +2 more
wiley +1 more source