Results 61 to 70 of about 571,919 (313)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Effects of short- and long-chain fatty acids on the expression of stearoyl-CoA desaturase and other lipogenic genes in bovine mammary epithelial cells

Animal, 2013
Stearoyl-CoA desaturase (SCD) in the bovine mammary gland introduces a cis-double bond at the Δ9 position in a wide range of fatty acids (FA). Several long-chain polyunsaturated fatty acids (PUFA) inhibit expression of SCD, but information on the effect ...
A.A.A. Jacobs, J. Dijkstra, J.S. Liesman, M.J. VandeHaar, A.L. Lock, A.M. van Vuuren, W.H. Hendriks, J. van Baal   +7 more
doaj   +1 more source

Influence of clover species in mixtures with grasses on fatty acid composition of mixtures [PDF]

, 2006
White clover (WC, Trifolium repens L.) or red clover (RC, Trifolium pratense L.) was grown in mixture with grasses. Samples of the mixtures and pure clovers were taken during three cuts, and the fatty acids (FA) compositions were determined.
Bleken, M.A., Langeland, Å., Steinshamn, H., Thuen, E.   +3 more
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Overcoming obstacles to innovation: Can an educated workforce help?

Journal of Innovation & Knowledge
Firms face many obstacles in their pursuit of innovation. However, the mechanisms that enable firms to surmount these challenges and foster innovation are less understood.
Benoit Dostie, Lene Kromann, Anders Sørensen   +2 more
doaj   +1 more source

The effect of fishmeal or peameal on milk fatty acid composition in organic farming [PDF]

, 2006
Feed fatty acid (FA) composition influences the FA composition of cow milk. In a continuous production experiment with 32 Norwegian red dairy cows fishmeal (FM) was compared to peameal (PM) as protein supplement to home-grown cereals and grass silage in ...
Adler, Steffen A., Randby, Åshild T.
core  

The Centurion 18 telescope of the Wise Observatory

, 2008
We describe the second telescope of the Wise Observatory, a 0.46-m Centurion 18 (C18) installed in 2005, which enhances significantly the observing possibilities. The telescope operates from a small dome and is equipped with a large-format CCD camera. In
A. Landolt, A.P. Boss, A.W. Harris, Assaf Berwald, Avi Shporer, B.M. Peterson, B.M. Peterson, C.W. Akerlof, D. Charbonneau, D. Charbonneau, D.L. Pollacco, David Polishook, E. Agol, E. Bowell, F.T. O’Donovan, G. Bakos, G.W. Henry, H. Netzer, H.L. Maness, I. Bowen, I.A. Steele, Ilan Manulis, J. Pepper, J.B. Pollack, J.E. Greene, J.J. Fortney, J.N. Winn, J.N. Winn, M. Gillon, M.J. Holman, N. Brosch, Noah Brosch, R.M. Zerbi, R.P. Butler, S. Kaspi, S.A. Yost, Shai Kaspi, T. Guillot, T. Mazeh   +38 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source