Immune niche composed of C1Q<sup>+</sup> macrophages/SFRP2<sup>+</sup> CAFs/CD8<sup>+</sup> T cells drives immunotherapy response in HER2-positive gastric cancer. [PDF]
Liao Y +11 more
europepmc +1 more source
Abstract Acquired lipodystrophy in the dermal white adipose tissue (DWAT) is an early phenotype of skin fibrosis, followed by the accumulation of extracellular matrix (ECM). Lipodystrophy syndromes are estimated to affect 1 in 20,000 people and are associated with metabolic comorbidities.
Suneeti R Madhavan +10 more
wiley +1 more source
Correction: Germline nuclear-predominant Pten murine model exhibits impaired social and perseverative behavior, microglial activation, and increased oxytocinergic activity. [PDF]
Sarn N, Thacker S, Lee H, Eng C.
europepmc +1 more source
PAE creates a unique inflammatory signature in the mature adult brain with region‐specific changes in genes implicated in glial‐immune function. We report at least 60 differentially expressed genes in different brain regions due to PAE, many of which are associated with neuroimmune function.
Alissa N. Jones +6 more
wiley +1 more source
Sera of Healthy First-Degree Relatives of SLE Patients Contain Autoantibodies to Globular Domains of C1q. [PDF]
Cholakova G +5 more
europepmc +1 more source
Protective and Pathogenic Antibodies to Citrullinated Antigens
ABSTRACT Autoimmune diseases start years before clinical onset. In rheumatoid arthritis (RA), autoantibodies to citrullinated proteins (ACPA) and to modified IgG (rheumatoid factors, RF) can be detected many years before the inflammatory attack on cartilaginous joints. It has been assumed that these antibodies are pathogenic.
Outi Sareila +5 more
wiley +1 more source
The serum C1q-to-CRP ratio performs well for diagnosing periprosthetic joint infection in revision arthroplasty. [PDF]
Jia X +5 more
europepmc +1 more source
From Sight to Stridor: Recurrent Angioedema in Systemic Lupus Erythematosus Associated With Complement Activation. [PDF]
Khalafi S, Felde L.
europepmc +1 more source
ABSTRACT Fibronectin glomerulopathy (FNG) is a rare renal disorder characterized by excessive glomerular fibronectin deposition, often associated with variants in the fibronectin 1 (FN1) gene. Clinically, FNG presents with proteinuria, hematuria, and hypertension, and may progress to end‐stage kidney disease.
Nobuhiro Kanazawa +7 more
wiley +1 more source
C1q CIC in Lupus Nephritis: An Analysis of 883 Patients. [PDF]
Chang HC +5 more
europepmc +1 more source

