Results 121 to 130 of about 58,368 (237)
Repurpose an FDA‐Approved Antibody Using DARPin‐Scaffolded Bridge Protein
Chemistry–Methods, Volume 6, Issue 5, May 2026.The cell line and scalable upstream/downstream process development needed for every new monoclonal antibody are both highly expensive and time‐consuming, significantly increasing the cost of new antibody therapeutics. By contrast, the production of many synthetic binders can be accomplished rapidly and with lower production costs.
Michael Woolley +4 more
wiley +1 more source
Clinical and Experimental Immunology, 2000 P, Eggleton, A J, Tenner, K B, Reid
openaire +3 more sources
Clinical &Translational Immunology, Volume 15, Issue 5, 2026.Abstract Objectives The anti‐PD‐L1 antibody avelumab has demonstrated efficacy across multiple cancer types. Avelumab primarily blocks the PD‐1/L1 immune checkpoint, while inducing antibody‐dependent cellular cytotoxicity (ADCC) from CD16a+ NK cells.
Lachlan J Dobson +6 more
wiley +1 more source
Journal of General and Family Medicine, Volume 27, Issue 3, May 2026.ABSTRACT Acquired angioedema (AAE) due to C1 inhibitor deficiency can present as acute abdomen. A 24‐year‐old woman developed severe abdominal pain and bowel wall edema initially suggestive of hereditary angioedema, but genetic testing excluded it. She later manifested fever, arthritis, rash, and serological abnormalities consistent with systemic lupus
Seiji Shiota +2 more
wiley +1 more source
Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management
MedComm, Volume 7, Issue 5, May 2026.The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang +12 more
wiley +1 more source
3D‐printing of Methacryloylated Recombinant Collagen for Tissue Engineering
ChemistrySelect, Volume 11, Issue 17, 5 May 2026.Recombinant collagen‐like proteins offer promise as alternatives to mammalian collagens. There is less risk of disease transfer, and changes in structure can be readily introduced. Here, a recombinant collagen‐like protein was methacryloylated for extrusion printing and rapid photo‐crosslinking.
Malachy K. Maher +7 more
wiley +1 more source
C1q nephropathy- unity in diversity.
Journal of renal injury prevention, 2013 Implication for health policy/practice/research/medical educationC1q nephropathy refers to a disorder in which C1q deposits are seen in mesangium on immunofluorescence microscopy and mesangial electron dense deposits on electron microscopy. The diagnosis of C1q nephropathy is based on demonstration of intense C1q (dominant or co-dominant) positivity ...
openaire +2 more sources
Aging Cell, Volume 25, Issue 5, May 2026.A Bruchs membrane (BrM) mimic based on aged decellularized BrM was developed and differentially expressed proteins in aged dECM‐BrM that may provide specific biochemical cues fundamental to model AMD in vitro were identified. RPE culture on aged dECM‐BrM developed certain AMD‐like features including reduced TEER and expression of drusen components ...
Blanca Molins +8 more
wiley +1 more source
Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease
European Journal of Neuroscience, Volume 63, Issue 9, May 2026.Microglia are dynamic, context‐dependent regulators of Alzheimer's disease, modulating amyloid, tau, and neurodegeneration across disease stages. Integrating multiscale and human‐focused approaches is essential to translate microglial biology into therapeutic strategies. ABSTRACT Microglia, the resident innate immune cells of the central nervous system,
Patricia Martínez‐Tazo +9 more
wiley +1 more source
Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence
Pediatric Blood &Cancer, Volume 73, Issue 5, May 2026.
Gabriele Mortari +9 more
wiley +1 more source