Results 91 to 100 of about 37,422 (167)
BMEMat, Volume 4, Issue 3, September 2026.The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang +6 more
wiley +1 more source
Chronic Paraquat Neurotoxicity and Dopaminergic Degeneration: A Mechanistic Review
Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.Occurrence of Parkinson's disease (PD) based on several neurotoxins. Advanced and comprehensive mechanisms based on Paraquat‐induced PD. Mechanism of oxidative stress, ROS and RNS formation, and death of dopaminergic neurons. The modulation of genes and proteins by paraquat leads to Parkinsonism.
Saima Riaz +5 more
wiley +1 more source
C1q and anti-C1q autoantibodies in (auto)immunity [PDF]
This thesis contains several investigations into the contribution of complement proteins, especially C1q, in several human diseases. Additionally, human autoantibodies against C1q (anti-C1q) are studied, cloned and characterized in order to further the ...
Dijkstra, D.J.
core
Clinical Case Reports, Volume 14, Issue 9, September 2026.ABSTRACT Common variable immunodeficiency (CVID) may initially manifest as undifferentiated connective tissue disease (UCTD) in the absence of recurrent infections or hypogammaglobulinemia. In patients presenting with warning signs, neither older age nor normal immunoglobulin levels should preclude consideration of CVID; early genetic testing is ...
Yu‐Jie Hu +4 more
wiley +1 more source
Exercise‐Induced Myonectin Protects Against Cerebral Ischemia–Reperfusion Injury
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.Exercise‐induced myonectin protects against cerebral ischemia–reperfusion injury. Myonectin knockout abolishes exercise benefits, whereas recombinant administration reduces cerebral infarct size. Mechanistically, myonectin activates PI3K/AKT/mTOR signaling, thereby suppressing excessive neuronal autophagy and microglial‐driven neuroinflammation ...
Jing Zhang +7 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.A recombinant AAV delivered tumour gene therapy. NF‐κB drives tumour‐selective antigen (e.g., CD20) expression. Ectopic CD20 enables rituximab repurposing to solid tumours. ADCC, ADCP, and CDC contribute to the antitumour activity. Abstract Background Despite the clinical success of cancer immunotherapies, their efficacy is often compromised by antigen‐
Ziyan Kong +6 more
wiley +1 more source
Expression and Functional Analysis of C1q-like and Mtmr8 in Fish
, 2009 在脊椎动物中，含有C1q结构域的C1q家族蛋白已有一些报道，但他们的生物学功能还不是很清楚。首先，我们鉴定了一个银鲫C1q-like因子(CagOC1q-like)，它已被确认为一种皮质颗粒组分。免疫荧光定位显示CagOC1q-like特异在滤泡表皮细胞上表达，并在完全长成的卵母细胞上同皮质颗粒一起。而且受精后，它会排出到卵黄周隙和卵膜上。由于它是第一个被发现在卵母细胞周围的滤泡细胞上表达的C1q家族成员，它被用于滤泡细胞凋亡和缺失的检测中。卵母细胞成熟和排出阶段 ...
梅洁
core
Spatiotemporal immune heterogeneity and precision immunotherapy for ovarian cancer
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.Graphical Highlights Spatiotemporal immune heterogeneity shapes distinct and evolving immune ecosystems in ovarian cancer. Multimodal biomarkers enable biologically informed patient stratification beyond static single‐marker approaches. Precision immunotherapy should match dominant immune barriers across lesions and treatment stages.
Xinfeng Yang +9 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.1. Microglial functions arise from dynamic, context‐dependent programs rather than fixed M1/M2 phenotypes. 2. Inflammatory, interferon‐responsive, phagocytic/lipid‐metabolic and repair‐associated programs coexist across disease stages and brain regions. 3.
Jie Chen +6 more
wiley +1 more source
Glia, Volume 74, Issue 9, September 2026.Activated microglia‐derived inflammatory signals drive astrocytic Piezo1 expression in both in vitro and in vivo models. Piezo1 upregulation modulates astrocytic Ca2+ dynamics and inflammatory gene expression, thereby limiting microglial activation. ABSTRACT Structural tissue alterations in numerous brain disorders can initiate mechanosensory signaling
Yanyang Bai +8 more
wiley +1 more source