Results 91 to 100 of about 58,368 (237)
Movement Disorders, EarlyView.Complement activation is implicated in Huntington's disease; ANX005 is a potent inhibitor of component C1q. ANX005 exhibited a generally manageable safety profile with rapid reduction in C1q in the cerebrospinal fluid. Functional ability on composite Unified Huntington's Disease Rating Scale and total functional capacity was maintained, with potential ...
Rajeev Kumar +15 more
wiley +1 more source
The Role of Complement in Synaptic Pruning and Neurodegeneration
ImmunoTargets and Therapy, 2021 Angela Gomez-Arboledas,1 Munjal M Acharya,2,3 Andrea J Tenner1,4,5 1Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA; 2Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA,
Gomez-Arboledas A, Acharya MM, Tenner AJ
doaj
Mannóz-kötő lektin és C1q szerepe dendritikus sejtek és makrofágok funkcióiban és immunregulációs folyamatokban = The role of mannose binding lectin (MBL) and Clq on various functions of dendritic cells and macrophages and on immunoregulation [PDF]
, 2007 Munkánk célja annak kiderítése volt, hogy az in vivo körülmények között IC-hez kapcsolódó C1q és MBL komplement fehérjék befolyásolják-e a dendritikus sejtek (DC-k) működését. A C1q-t erősen kötötték a sejtek, viszont az MBL nem kötődött A sejteket C1q-
Bajtay, Zsuzsa +2 more
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Current Status of Kidney Xenotransplantation in Basic Research
Organ Medicine, EarlyView.Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley +1 more source
Frontiers in Immunology, 2019 Previous infection with Epstein-Barr virus (EBV) is believed to trigger autoimmunity and to drive autoantibody generation as occurring in patients with systemic lupus erythematosus (SLE). Complement C1q and autoantibodies targeting it (anti-C1q) are also
Kinga Csorba +8 more
doaj +1 more source
Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang +3 more
wiley +1 more source
Elementary derivations of identities for bilateral basic hypergeometric series
, 2000 We give elementary derivations of several classical and some new summation and transformation formulae for bilateral basic hypergeometric series. For purpose of motivation, we review our previous simple proof ("A simple proof of Bailey's very-well-poised
Schlosser, M.
core +1 more source
Allergy, EarlyView.ABSTRACT Hereditary angioedema (HAE) with C1 inhibitor deficiency is a rare disease characterized by unpredictable episodes of tissue swelling (angioedema), which, in most cases, occur first under the age of 18 years, and entail a significant burden of disease not only for the patients but also for their families.
Henriette Farkas +128 more
wiley +1 more source
Scientific Reports, 2017 C1q collagen-like region (CLR) engaging and activating the LAIR-1 inhibitory immunoreceptor represents a non-complement mechanism for maintaining immune quiescence.
Myoungsun Son +5 more
doaj +1 more source
Detection of antibody-dependent complement mediated inactivation of both autologous and heterologous virus in primary HIV-1 infection [PDF]
, 2005 Specific CD8 T-cell responses to human immunodeficiency virus type 1 (HIV-1) are induced in primary infection and make an important contribution to the control of early viral replication.
Aasa-Chapman, M.M.I. +10 more
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