Results 171 to 180 of about 2,307,989 (279)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Identification of feline-like rotavirus strains in Sabah State of Malaysian Borneo. [PDF]

Trop Med Health
Jelfree ABM, Mori D, Akari Y, John JL, Amit LN, Rahim SSBSA, Komoto S, Joseph J, Ahmed K.   +8 more
europepmc   +1 more source

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Chronic Irreducible C1-C2 Rotatory Subluxation Presenting as Painful Torticollis in a Child Managed with Posterior Lateral Mass Fixation: A Case Report. [PDF]

J Orthop Case Rep
Debbarma S, Sharma C, Baishya A, Khonglah TG, Borgohain B, Agarwal S.   +5 more
europepmc   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Normative segmental cervical lordosis distribution and sagittal vertical axis variations with T1 slope: Defining the role of the C2-C5 segment. [PDF]

J Craniovertebr Junction Spine
Bagherzadeh S, Kopparapu S, Roohollahi F, Kumar J, Bauer S, Neal E, Noureldine MHA, Pressman E, Alikhani P, Rostami M.   +9 more
europepmc   +1 more source

Stabilization of Single Metal Atoms on Graphitic Carbon Nitride: Synthetic Strategies and Emerging Applications

Advanced Science, EarlyView.
This review highlights recent advancements in stabilizing single metal atoms on graphitic carbon nitride emphasizing innovative synthesis strategies and emerging applications in electrocatalysis, photocatalysis and organic transformations, along with key challenges and future perspective. Abstract Emerging as a new frontier in catalysis science, single‐
Wenyao Zhang, Junjie Cui, Zhenjie Yao, Boyuan Zhu, Nithinraj Panangattu Dharmarajan, Ajayan Vinu, Junwu Zhu   +6 more
wiley   +1 more source

Subaxial sagittal shifts postatlantoaxial fusion - Radiological assessment and clinical analysis. [PDF]

J Craniovertebr Junction Spine
Singh DK, Sangolli PN, Singh N, Mishra VK, Vashisth KK.   +4 more
europepmc   +1 more source

A Perspective on Interactive Theorem Provers in Physics

Advanced Science, EarlyView.
Into an interactive theorem provers (ITPs), one can write mathematical definitions, theorems and proofs, and the correctness of those results is automatically checked. This perspective goes over the best usage of ITPs within physics and motivates the open‐source community run project PhysLean, the aim of which is to be a library for digitalized physics
Joseph Tooby‐Smith
wiley   +1 more source

Th@C₈₄ Revisited: Lost in the Corners of One's Own Cage. [PDF]

J Phys Chem A
Kaminský J, Jaroš A, Straka M.
europepmc   +1 more source