Results 191 to 200 of about 2,307,989 (279)

Stepwise B[triple bond, length as m-dash]N bond cleavage by isocyanides: access to the 3-azaborole structural motif. [PDF]

Chem Sci
Xiang L, Kwan KH, Jing Y, Wang J, Matler A, Chen X, Lin Z, Ye Q.   +7 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

A Clinical Experience in Treating Myelopathy Caused by Floating Lamina Resulting from Re-close of the Lamina and Pseudarthrosis at the Lateral Gutter after Cervical Laminoplasty. [PDF]

J Orthop Case Rep
Tsukamoto A, Osima T, Fujimoto S, Morita T, Teramoto A.   +4 more
europepmc   +1 more source

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

Advanced Science, EarlyView.
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan, Xuelin Wang, Zhongyao Chen, Shuo Wang, Weining Gao, Ziyi Chen, Runyang Li, Cheng Hao, Lei Zhang, Qiongqiong Zhang, Ke Zhang, Mei Yu, Qian Liu, Jingxuan Wang, Huiping Li, Simpkins Fiona, Jing Liu, Qiang Liu, Peng Liu, Yawei Hu   +19 more
wiley   +1 more source

Examining the association between fetal HLA-C, maternal KIR haplotypes and birth weight. [PDF]

PLoS Genet
Decina CS, Warrington NM, Beaumont RN, Bian B, Brito Nunes C, Wang G, Lowe WL, Squire D, Vukcevic D, Leslie S, Freathy RM, Evans DM.   +11 more
europepmc   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Syntheses and crystal structures of di-chlorido-(2,6-di-methyl-pyrazine-κ<i>N</i>)(methanol-κ<i>O</i>)zinc(II), di-bromido-(2,6-di-methyl-pyrazine-κ<i>N</i>)(methanol-κ<i>O</i>)zinc(II) and aqua-(2,6-di-methyl-pyrazine-κ<i>N</i>)di-iodido-zinc(II). [PDF]

Acta Crystallogr E Crystallogr Commun
Näther C.
europepmc   +1 more source

Synergistic Ion Transport and Spatial Confinement in Sb‐Embedded Hollow Carbon Nanofibers for Stable Na Metal Anodes

Advanced Science, EarlyView.
This work presents a 3D Sb‐embedded hollow carbon nanofiber (Sb@HCF) host for ultra‐stable Na metal anodes. Experimental analyses and theoretical simulations clearly uncovers that in situ formed Na‐Sb alloy guides uniform Na deposition and serves as efficient ion transport highways. The Sb@HCF‐based cells achieve exceptional cycling stability in half‐,
Feng Han, Menghuan Yuan, Hui Wang, Baitao Liu, Dezhi Kong, Yongtao Tian, Xinjian Li, Ye Wang, Tingting Xu, Hui Ying Yang   +9 more
wiley   +1 more source

The association between cervical sagittal balance parameters and clinical outcomes after single-level surgery for cervical radiculopathy and/or stenosis: A systematic review and meta-analysis. [PDF]

Brain Spine
Gül A, Gomez Farias J, Goedmakers CM, Mekary RA, Vleggeert-Lankamp C.   +4 more
europepmc   +1 more source

Atomic Tuning of Metal‐Support Interactions for Pathway‐Selective CO2 Photoreduction on TiO2

Advanced Science, EarlyView.
Single‐atom Fe and Cu catalysts anchored on TiO2 steer photocatalytic CO2 reduction toward distinct pathways. Fe sites favor rapid *CO desorption and selective CO formation, whereas Cu sites stabilize *CHO intermediates, enabling deep reduction and C─C coupling. Combined spectroscopy and DFT calculations reveal how metal–support interactions and oxygen
Dongyun Kim, Wonjae Ko, Byoung‐Hoon Lee, Sanghoon Kim, Yun Do Kim, Hyunsoo Ahn, Yoon Jung, Chan Woo Lee, Kug‐Seung Lee, Eunhee Gong, Junho Lee, Minho Kim, Taeghwan Hyeon, Su‐Il In   +13 more
wiley   +1 more source