Results 1 to 10 of about 40,889 (265)

Clozapine-N-oxide impairs spatial memory independent of DREADDs [PDF]

Frontiers in Cellular Neuroscience
Chemogenetic studies using Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) enable the precise manipulation of neuronal activity in specific brain regions and cell types.
Brayden Bunce, Anna A. VanKampen, Annie He, Sara J. Aton, Frank Raven   +4 more
doaj   +2 more sources

C20-C21-C23 tricyclic terpanes abundance patterns: Origin and application to depositional environment identification

Frontiers in Earth Science, 2023
Reconstruction of paleo-depositional environments in a sedimentary basin is often obstructed by the absence of typical environmental indicators in sedimentary rocks.
Aiguo Wang, Chunyu Li, Long Li, Renhai Pu, Zeguang Yang, Nan Zhu, Kai Guo   +6 more
doaj   +1 more source

Seven days treatment with the angiotensin II type 2 receptor agonist C21 in hospitalized COVID-19 patients; a placebo-controlled randomised multi-centre double-blind phase 2 trial

EClinicalMedicine, 2021
: Background: COVID-19 morbidity and mortality remains high and the need for safe and effective drugs continues despite vaccines. Methods: Double-blind, placebo-controlled, multi-centre, randomised, parallel group phase 2 trial to evaluate safety and ...
Göran Tornling, Rohit Batta, Joanna C. Porter, Bryan Williams, Thomas Bengtsson, Kartikeya Parmar, Reema Kashiva, Anders Hallberg, Anne Katrine Cohrt, Kate Westergaard, Carl-Johan Dalsgaard, Johan Raud   +11 more
doaj   +1 more source

Angiotensin AT2 Receptor Stimulation Alleviates Collagen-Induced Arthritis by Upregulation of Regulatory T Cell Numbers

Frontiers in Immunology, 2022
The angiotensin AT2 receptor (AT2R) is a main receptor of the protective arm of the renin-angiotensin system and exerts for instance anti-inflammatory effects. The impact of AT2R stimulation on autoimmune diseases such as rheumatoid arthritis (RA) is not
Bettina Sehnert, Veronica Valero-Esquitino, Georg Schett, Georg Schett, Thomas Unger, Ulrike Muscha Steckelings, Reinhard Edmund Voll, Reinhard Edmund Voll   +7 more
doaj   +1 more source

Facilitation of TRKB Activation by the Angiotensin II Receptor Type-2 (AT2R) Agonist C21

Pharmaceuticals, 2021
Blockers of angiotensin II type 1 receptor (AT1R) exert antidepressant-like effects by indirectly facilitating the activation of the angiotensin II type 2 receptor (AT2R), which leads to increased surface expression and transactivation of tropomyosin ...
Liina Laukkanen, Cassiano R. A. F. Diniz, Sebastien Foulquier, Jos Prickaerts, Eero Castrén, Plinio C. Casarotto   +5 more
doaj   +1 more source

Global Economic Uncertainties and Exchange Rate Management in Africa: A Panel Study

Acta Universitatis Sapientiae: Economics and Business, 2022
This study investigates the effects of global economic uncertainties on exchange rate management in Africa from 1990 to 2021. Employing the quantile regression technique, findings show that both global and domestic economic uncertainties have significant
Adedokun Adeniyi J., Falayi Olabusuyi R., Adeyemi Francis O., Kumeka Terver T.   +3 more
doaj   +1 more source

A review of literature on Compound 21-loaded gelatin nanoparticle: a promising nose-to-brain therapy for multi-infarct dementia

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2023
Multi-infarct dementia (MID) is described as a chronic progressive decline in cortical cognitive function due to the occurrence of multiple infarcts in the cerebral vascularization throughout the gray and white matter.
Bryan Gervais de Liyis, Jane Carissa Sutedja, Putu Mas Isyundra Kesuma, Sulaiman Liyis, I. Putu Eka Widyadharma   +4 more
doaj   +1 more source

Direct angiotensin II type 2 receptor stimulation ameliorates insulin resistance in type 2 diabetes mice with PPARγ activation. [PDF]

PLoS ONE, 2012
ObjectivesThe role of angiotensin II type 2 (AT(2)) receptor stimulation in the pathogenesis of insulin resistance is still unclear. Therefore we examined the possibility that direct AT(2) receptor stimulation by compound 21 (C21) might contribute to ...
Kousei Ohshima, Masaki Mogi, Fei Jing, Jun Iwanami, Kana Tsukuda, Li-Juan Min, Akiyoshi Ogimoto, Björn Dahlöf, Ulrike M Steckelings, Tomas Unger, Jitsuo Higaki, Masatsugu Horiuchi   +11 more
doaj   +1 more source

Corporate Taxation in the European Union: The Role of Intangibles in the Formulary Apportionment

Review of Economic Perspectives, 2023
This paper seeks to contribute to the current debate on EU-wide corporate taxation, steered by the impending Proposal by the European Commission on a new framework for the taxation of income of businesses in Europe.
Mlčúchová Markéta
doaj   +1 more source

Stimulation of Angiotensin II Type 2 Receptor Modulates Pro-Inflammatory Response in Microglia and Macrophages: Therapeutic Implications for the Treatment of Stroke

Life, 2023
Background: Sustained microglial activation contributes to the development of post-stroke cognitive impairment (PSCI). Compound 21 (C21), an angiotensin II type 2 receptor agonist, has shown some neurovascular protection after stroke. This study aimed to
Abdulkarim Alshammari, Yohan Han, Timothy W. Jones, Bindu Pillai, Duo Zhang, Adviye Ergul, Payaningal R. Somanath, Susan C. Fagan   +7 more
doaj   +1 more source