Results 91 to 100 of about 42,643 (266)

Dexamethasone-(C21-phosphoramide)-[anti-EGFR]: molecular design, synthetic organic chemistry reactions, and antineoplastic cytotoxic potency against pulmonary adenocarcinoma (A549)

open access: yesDrug Design, Development and Therapy, 2016
Cody P Coyne,1 Lakshmi Narayanan2 1Department of Basic Sciences, 2Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, MS, USA Purpose: Corticosteroids are effective in the management of a variety ...
Coyne CP, Narayanan L
doaj  

Three‐Dimensional Optical and Computational Reconstruction of Colloidal Electrokinetic Flows via Multiplane Imaging and Multiscale Modeling

open access: yesSmall, EarlyView.
Fast 3D multiplane microscopy is combined with multiscale electrokinetic modeling to reconstruct nanoparticle motion around quadrupolar electrodes. This integrated optical‐computational framework reveals the full three‐dimensional structure of colloidal electrokinetic flows, including localized trapping, depletion layers, and complex vortical motion ...
Flip de Jong   +23 more
wiley   +1 more source

Clozapine-N-oxide impairs spatial memory independent of DREADDs

open access: yesFrontiers in Cellular Neuroscience
Chemogenetic studies using Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) enable the precise manipulation of neuronal activity in specific brain regions and cell types.
Brayden Bunce   +4 more
doaj   +1 more source

Reflective practice in the C21 curriculum [PDF]

open access: yesThe British Student Doctor Journal, 2020
Hodges, Elizabeth   +2 more
openaire   +2 more sources

Interface Engineering for Expanded Stable Polarization Regime Upon Cycling in Ferroelectric Hf0.5Zr0.5O2

open access: yesSmall, EarlyView.
Interfaces can be crucial on the properties of ferroelectric HfO2. In this work, it is demonstrated that a top nanolayer of ZrO2 significantly improves the ferroelectric properties of epitaxial La‐doped HfO2 films on SrTiO3(001). Endurance reaches 1011 cycles with a technological window of 108 cycles, in which the remanent polarization variation is ...
M. Ghiasabadi Farahani   +5 more
wiley   +1 more source

A Luminescent PEI/Cy5‐Citrate‐Functionalized Carbonated Apatite Nanoplatform for In Vitro Gene Delivery and In Vivo Traceability

open access: yesSmall, EarlyView.
A luminescent PEI/Cy5‐citrate‐functionalized carbonated apatite nanoplatform combines biocompatibility, plasmid delivery, and Cy5‐based traceability. The system enables effective in vitro gene delivery while preserving cell viability and allows real‐time in vivo fluorescence tracking of the nanocarrier.
Laura Garrido Martín   +5 more
wiley   +1 more source

Safeguarding the Photoluminescence of Silver Sulfide Nanocrystals in Biological Environments via Silica Shielding

open access: yesSmall, EarlyView.
Interactions with biomolecules can alter the photoluminescence of Ag2S nanocrystals, undermining near‐infrared imaging and thermometry. Incorporation into dendritic silica minimizes these interactions and preserves emission intensity, spectral response, and lifetime in plasma and whole blood. This shielding enables more reliable imaging and temperature
Alejandro Hernández Medel   +11 more
wiley   +1 more source

Compound 21, a two-edged sword with both DREADD-selective and off-target outcomes in rats

open access: yesPLoS ONE, 2020
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) represent a technical revolution in integrative neuroscience. However, the first used ligands exhibited dose-dependent selectivity for their molecular target, leading to potential ...
Raphaël Goutaudier   +4 more
doaj  

Foreword to the special edition of C21 Literature

open access: yesC21 Literature: Journal of 21st-Century Writings, 2018
A foreword to the special issue of C21 by David Mitchell.
openaire   +2 more sources

An ‘Empty’ [Fe16] Cage and its Transformation into [Fe17] and [Fe30]

open access: yesSmall, EarlyView.
Polymetallic clusters of FeIII constructed without organic bridging ligands are an emerging class of molecules with structures akin to iron oxide minerals, possessing large spin ground states and/or displaying spin frustration effects. All previous examples, [Fe8], [Fe17], [Fe30] and [Fe34], have been isolated from pyridine or analogous heterocyclic ...
Annabel J. MacGregor   +12 more
wiley   +1 more source

Home - About - Disclaimer - Privacy