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C3 Glomerulopathy

Pediatric Nephrology, 2016
Recent advances in our understanding of the disease pathology of membranoproliferative glomerulonephritis has resulted in its re-classification as complement C3 glomerulopathy (C3G) and immune complex-mediated glomerulonephritis (IC-GN). The new consensus is based on its underlying pathomechanism, with a key pathogenetic role for the complement ...
Magdalena, Riedl   +2 more
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C3-Modules

Algebra Colloquium, 2015
One of the continuity conditions identified by Utumi on self-injective rings is the C3-condition, where a module M is called a C3-module if whenever A and B are direct summands of M and A ∩ B=0, then A ⊕ B is a summand of M. In addition to injective and direct-injective modules, the class of C3-modules includes the semisimple, continuous ...
Amin, Ismail   +2 more
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Pure C3 modules

Asian-European Journal of Mathematics, 2023
Within the paper, we study the class of modules in which the direct sum of two disjoint summands that is a pure submodule is also a summand. This class of modules is considered [Formula: see text] modules, a generalization of [Formula: see text] modules. In addition to pure-injective and [Formula: see text] modules that belong to the class of [Formula:
Kaushal Gupta, Ashok Ji Gupta
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C3 Glomerulopathy

2013
C3 glomerulopathy is a recent disease classification comprising several rare types of glomerulonephritis, including dense deposit disease (DDD) and C3 glomerulonephritis (C3GN). The most common histological feature in these diseases is the presence of glomerular deposition of C3 within the mesangium and along the glomerular basement membrane (GBM) in ...
Aude, Servais   +3 more
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Effect of C3 Inactivator on Bound C3 Antigen

The Journal of Immunology, 1972
Abstract The effect of C3 inactivator (C3ina) in human EDTA plasma on C3 antigen bound to various immune complexes was determined. C3ina greatly decreased the amount of C3 bound to human erythrocytes sensitized with IgM anti-I cold agglutinin, and also decreased erythrocyte-bound C3 of a patient with deficiency of C3 inactivator, but had
E J, Leonard, T, Borsos
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Homozygous C3 deficiency: Detection of C3 by radioimmunoassay

Clinical Immunology and Immunopathology, 1977
Abstract A 5 10 12 - year-old girl with recurrent infections was found to have homozygous C3 deficiency. Family studies demonstrated that the pattern of inheritance was consistent with that of an autosomal codominant trait. C3 levels have ranged from 5 mg/100 ml (electroimmunoassay) to 1.7 μg/100 ml (radioimmunoassay) 2 years later.
A E, Davis   +6 more
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C3 nephritic factor associated with C3 glomerulopathy in children

Pediatric Nephrology, 2013
C3 glomerulopathy (C3G) is characterized by predominant C3 deposits in glomeruli and dysregulation of the alternative pathway of complement. Half of C3G patients have a C3 nephritic factor (C3NeF). C3G incorporated entities with a range of features on microscopy including dense deposit diseases (DDD) and C3 glomerulonephritis (C3GN).
Camille, Nicolas   +16 more
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Inherited complement C3 deficiency: A defect in C3 secretion

European Journal of Immunology, 1994
AbstractThe molecular basis of inherited complement C3 deficiency in a 20‐year‐old newly diagnosed male patient was studied. Using an enzyme‐linked immunosorbent assay, the patient's C3 serum level was found to be approximately 7 μg/ml, which is less than 1 % of normal.
Y, Katz   +4 more
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C3-Like Activity in C3-Deficient Dog Serum

Complement, 1987
A complete absence of the third component of complement has been demonstrated in a colony of Brittany spaniels. The deficiency is inherited in an autosomal recessive fashion and is clinically characterized by an increased susceptibility to infection and renal disease.
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