Results 201 to 210 of about 27,277 (237)

Effective inhibition of C3a‐mediated pro‐inflammatory response by a human C3a‐specific protein binder

Biotechnology and Bioengineering, 2020
AbstractComplement component 3a (C3a) plays a crucial role in the immune response and host defense, but it is also involved in pro‐inflammatory responses, causing many inflammatory disorders. Blockade of C3a has been regarded as a potent therapeutic strategy for inflammatory diseases.
Yoo‐Kyoung Sohn, Sumin Son, Yoonjoo Choi, Da‐Eun Hwang, Hyo‐Deok Seo, Joong‐jae Lee, Hak‐Sung Kim   +6 more
openaire   +2 more sources

Aristolochic acid I promotes the invasion and migration of hepatocellular carcinoma cells by activating the C3a/C3aR complement system.

Toxicology Letters, 2020
Aristolochic acid is an established human carcinogen. Previous reports have demonstrated a link between aristolochic acid exposure and liver cancer prevalence in Asia.
Yu Li, Sirui Zhu, Mei Xue, Ye Jing, Xiaoli Liu, Danhong Cai, Ye Zhao, Yaoyao Bian, Zhaofeng Zhang, Liang Zhang   +9 more
semanticscholar   +1 more source

Hydration of C3A/gypsum composites in the presence of graphene oxide

, 2020
The interactions between graphene oxide (GO) and individual clinker phases, which are critical for understanding the mechanism of GO during the hydration of cementitious materials, remain unclear.
Xiaojuan Kang, Xiaohong Zhu, Jiaping Liu, X. Shu, J. Qian, Yongbo Huang   +5 more
semanticscholar   +1 more source

Designing synthetic superagonists of C3a anaphylatoxin

Biochemistry, 1991
An extensive structure-activity study of synthetic analogues of the C3a anaphylatoxin was conducted. Our goal was to map C3a-C3a receptor interactions by designing synthetic analogue molecules having maximal biologic potency. Nonspecific binding of the polycationic C3a to polyanionic molecules on cellular surfaces often obscures specific binding to the
J A, Ember, N L, Johansen, T E, Hugli
openaire   +2 more sources

Anti-C3a, Anti-C3B (Anti-B) and Their Reaction with the Anaphylatoxic Fragment C3a

The Journal of Immunology, 1973
Abstract Specific antisera against the third human complement component (C3) and its fragments (C3a, C3c and C3d) were raised in rabbits. The reactions of anti-C3B (anti-B) with the anaphylatoxic fragment C3a were investigated by means of line electrophoresis, agglutination inhibition and Prausnitz-Küstner type reactions.
J L, Molenaar, A, ten Velde, K W, Pondman   +2 more
openaire   +2 more sources

C3a receptor on dibutyryl-cAMP-differentiated U937 cells and human neutrophils: The human C3a receptor characterized by functional responses and 125I-C3a binding

Biochemistry, 1992
The anaphylatoxic peptide C3a is part of a basic immunological defense mechanism, the complement system. Research on the human C3a receptor and signal transduction is hampered by the lack of a suitable human cell or cell line. We screened tumor cell lines and human blood cells for a C3a-dependent increase in cytosolic Ca2+ ([Ca2+]i) and analyzed this ...
A, Klos, S, Bank, C, Gietz, W, Bautsch, J, Köhl, M, Burg, T, Kretzschmar   +6 more
openaire   +2 more sources

Modulation of C3a Activity: Internalization of the Human C3a Receptor and its Inhibition by C5a

The Journal of Immunology, 1999
AbstractThe C3a receptor (C3aR) is expressed on most human peripheral blood leukocytes with the exception of resting lymphocytes, implying a much higher pathophysiological relevance of the anaphylatoxin C3a as a proinflammatory mediator than previously thought.
B, Settmacher, D, Bock, H, Saad, S, Gärtner, C, Rheinheimer, J, Köhl, W, Bautsch, A, Klos   +7 more
openaire   +2 more sources

Complement anaphylatoxins C3a and C5a: Emerging roles in cancer progression and treatment.

Seminars in Cell and Developmental Biology, 2017
Recent insights into the role of complement anaphylatoxins C3a and C5a in cancer provide new opportunities for the development of innovative biomarkers and therapeutic strategies. These two complement activation products can maintain chronic inflammation,
D. Ajona, S. Ortiz-Espinosa, R. Pio
semanticscholar   +1 more source

Anaphylatoxin C3a peptide contracts human pulmonary vasculature

Pulmonary Pharmacology, 1988
Complement anaphylatoxin C3a C-terminus octapeptide Ala-Ala-Ala-Leu-Gly-Leu-Ala-Arg (C3apep) contracted both pulmonary artery (PA) and pulmonary vein (PV) in a dose-dependent manner over the concentration range of 0.1 micrograms/ml to 100 micrograms/ml with the latter having maximal contractile activity. Removal of the terminal arginine caused complete
R R, Schellenberg, J B, Mullen, A, Foster, M M, Glovsky   +3 more
openaire   +2 more sources

Aristolochic acid I aggravates renal injury by activating the C3a/C3aR complement system.

Toxicology Letters, 2019
Previous studies have reported that the complement system is unconventionally activated in many kinds of glomerulonephritis. Multiple complement components participate in the pathogenic process by triggering immune response or other intracellular ...
Jing Ye, Z. Qian, Mei Xue, Yamin Liu, Sirui Zhu, Y. Li, Xiaoli Liu, Danhong Cai, J. Rui, Liang Zhang   +9 more
semanticscholar   +1 more source