Results 211 to 220 of about 24,276 (249)

Anti-C3a, Anti-C3B (Anti-B) and Their Reaction with the Anaphylatoxic Fragment C3a

The Journal of Immunology, 1973
Abstract Specific antisera against the third human complement component (C3) and its fragments (C3a, C3c and C3d) were raised in rabbits. The reactions of anti-C3B (anti-B) with the anaphylatoxic fragment C3a were investigated by means of line electrophoresis, agglutination inhibition and Prausnitz-Küstner type reactions.
J L, Molenaar, A, ten Velde, K W, Pondman   +2 more
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Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous Nephropathy

Journal of the American Society of Nephrology, 2022
Background The complement system is highly activated in primary membranous nephropathy (MN). Identifying the complement components that damage podocytes has important therapeutic implications. This study investigated the role of C3a and the C3a receptor (C3aR) in the pathogenesis of MN.
Shuang Gao, Zhao Cui, Ming-hui Zhao
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Modulation of C3a Activity: Internalization of the Human C3a Receptor and its Inhibition by C5a

The Journal of Immunology, 1999
Abstract The C3a receptor (C3aR) is expressed on most human peripheral blood leukocytes with the exception of resting lymphocytes, implying a much higher pathophysiological relevance of the anaphylatoxin C3a as a proinflammatory mediator than previously thought.
B, Settmacher, D, Bock, H, Saad, S, Gärtner, C, Rheinheimer, J, Köhl, W, Bautsch, A, Klos   +7 more
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Development of a simple radioimmunoassay for human C3a

Inflammation, 1988
A radioimmunoassay was devised for the human complement cleavage product, C3a, using charcoal separation and selective precipitation of interfering substances. When compared with the commercially available immunoassay now marketed, the assay reported here was somewhat simpler to perform; furthermore, it overcame delivery and availability problems in ...
H R, Lamche, E, Paul, G, Schlag, H, Redl, D E, Hammerschmidt   +4 more
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Effective inhibition of C3a‐mediated pro‐inflammatory response by a human C3a‐specific protein binder

Biotechnology and Bioengineering, 2020
AbstractComplement component 3a (C3a) plays a crucial role in the immune response and host defense, but it is also involved in pro‐inflammatory responses, causing many inflammatory disorders. Blockade of C3a has been regarded as a potent therapeutic strategy for inflammatory diseases.
Yoo‐Kyoung Sohn, Sumin Son, Yoonjoo Choi, Da‐Eun Hwang, Hyo‐Deok Seo, Joong‐jae Lee, Hak‐Sung Kim   +6 more
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C3a receptor on dibutyryl-cAMP-differentiated U937 cells and human neutrophils: The human C3a receptor characterized by functional responses and 125I-C3a binding

Biochemistry, 1992
The anaphylatoxic peptide C3a is part of a basic immunological defense mechanism, the complement system. Research on the human C3a receptor and signal transduction is hampered by the lack of a suitable human cell or cell line. We screened tumor cell lines and human blood cells for a C3a-dependent increase in cytosolic Ca2+ ([Ca2+]i) and analyzed this ...
A, Klos, S, Bank, C, Gietz, W, Bautsch, J, Köhl, M, Burg, T, Kretzschmar   +6 more
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The Primary Structure of Porcine C3a Anaphylatoxin

The Journal of Immunology, 1976
Abstract Porcine C3a was generated in whole porcine serum by inulin activation of enzymes of the alternative complement pathway. The C3a anaphylatoxin was isolated according to the procedures previously described by Hugli. The complete amino acid sequence for porcine C3a was determined utilizing automatic sequencing techniques in ...
N C, Corbin, T E, Hugli
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Designing synthetic superagonists of C3a anaphylatoxin

Biochemistry, 1991
An extensive structure-activity study of synthetic analogues of the C3a anaphylatoxin was conducted. Our goal was to map C3a-C3a receptor interactions by designing synthetic analogue molecules having maximal biologic potency. Nonspecific binding of the polycationic C3a to polyanionic molecules on cellular surfaces often obscures specific binding to the
J A, Ember, N L, Johansen, T E, Hugli
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Structure and Function of C3a Anaphylatoxin*

1990
The C3a molecule is one of three activation fragments from the complement cascade, a family of factors that include C3a, C4a, and C5a. Early recognition that more than one bio active fragment was generated during complement activation cascade must be credited to COCHRANE and MULLER-EBERHARD (1968) and to DIAS DA SILVA et al. (1967). These investigators
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The Role of Complement C3a Receptor in Stroke

NeuroMolecular Medicine, 2019
The complement system is a key regulator of the innate immune response against diseased tissue that functions across multiple organ systems. Dysregulation of complement contributes to the pathogenesis of a number of neurological diseases including stroke.
Saif Ahmad, Kanchan Bhatia, Adam Kindelin, Andrew F. Ducruet   +3 more
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