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Exosome Tethering Requires Tetherin Homodimerisation. [PDF]
Biol CellYıldızhan Y +5 more
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Synthetic C3a analogs as specific inhibitors of C3a activity
Immunopharmacology, 1981Various C3a-related C-terminal synthetic oligopeptides were investigated for their ability to induce a release of serotonin from guinea pig platelets. The results confirm earlier findings that expression of biological C3a activity requires the four to five C-terminal amino acids of the C3a primary structure and underlines the essential role of the C ...
D Bitter-Suermann, U Hadding
exaly +3 more sources
C3a(desArg) does not bind to and signal through the human C3a receptor
Immunology Letters, 1999Contradictory results have been published in the past regarding the functional responses of different cell types to the anaphylatoxin C3a and its natural catabolite C3a(desArg). To elucidate the interaction of the C3a receptor (C3aR) with its ligand(s) we studied the binding of human recombinant C3a (rC3a) and rC3a(desArg) to RBL-2H3 transfectants ...
Thomas Werfel +2 more
exaly +3 more sources
Ligands for C3a and C5a Receptors [PDF]
, 2023 Prolonged activation of the complement system of blood proteins in response to infection or tissue injury can lead to inflammatory diseases. This thesis investigates the potency, selectivity and structures of reported and rationally designed new ligands for human complement receptors C3aR and C5aR, towards development of new therapeutic agents. Chapter
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Pharmacological activity of C3a and C3a receptor ligands
2023The complement system is an integral component of the innate immune response to infection and injury. The anaphylatoxins, C3a and C5a, are produced upon activation of the classical, alternative or mannan-binding lectin complement pathways. C5a is a potent pro-inflammatory mediator and overactivation or underegulation of C5a is implicated in the ...
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Reevaluation of the C3a active site using short synthetic C3a analogues
European Journal of Immunology, 1990AbstractIn 1980 the C‐terminal pentapeptide LGLAR (C3a 73–77) was described (Caporale, L. H. et al. J. Biol. Chem. 1980. 255: 10758) as the minimal sequence inducing a C3a‐specific activity. We have synthesized C3a‐analogue peptides connected to non‐peptidic acyl residues known to potentiate biological activity.
J, Köhl +7 more
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Complement factors C3a and C5a have distinct hemodynamic effects in the rat [PDF]
International Immunopharmacology, 2009 In the rat, C5a infusion mediates well-defined effects including hypotension and neutropenia. Conversely, the comparative effect of C3a in the rat is not yet defined.
Tyson Moore +2 more
exaly +2 more sources
1978
Publisher Summary This chapter discusses the structural and functional characterization of anaphylatoxins, spasmogenic substances released during complement activation. These low molecular weight peptide fragments of C3 and C5 elicit a variety of cellular responses, which implies that they play a significant role in inflammation and acute allergic ...
T E, Hugli, H J, Müller-Eberhard
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Publisher Summary This chapter discusses the structural and functional characterization of anaphylatoxins, spasmogenic substances released during complement activation. These low molecular weight peptide fragments of C3 and C5 elicit a variety of cellular responses, which implies that they play a significant role in inflammation and acute allergic ...
T E, Hugli, H J, Müller-Eberhard
openaire +2 more sources