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The Primary Structure of Porcine C3a Anaphylatoxin
The Journal of Immunology, 1976Abstract Porcine C3a was generated in whole porcine serum by inulin activation of enzymes of the alternative complement pathway. The C3a anaphylatoxin was isolated according to the procedures previously described by Hugli. The complete amino acid sequence for porcine C3a was determined utilizing automatic sequencing techniques in ...
N C, Corbin, T E, Hugli
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Designing synthetic superagonists of C3a anaphylatoxin
Biochemistry, 1991An extensive structure-activity study of synthetic analogues of the C3a anaphylatoxin was conducted. Our goal was to map C3a-C3a receptor interactions by designing synthetic analogue molecules having maximal biologic potency. Nonspecific binding of the polycationic C3a to polyanionic molecules on cellular surfaces often obscures specific binding to the
J A, Ember, N L, Johansen, T E, Hugli
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Structure and Function of C3a Anaphylatoxin*
1990The C3a molecule is one of three activation fragments from the complement cascade, a family of factors that include C3a, C4a, and C5a. Early recognition that more than one bio active fragment was generated during complement activation cascade must be credited to COCHRANE and MULLER-EBERHARD (1968) and to DIAS DA SILVA et al. (1967). These investigators
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The Role of Complement C3a Receptor in Stroke
NeuroMolecular Medicine, 2019The complement system is a key regulator of the innate immune response against diseased tissue that functions across multiple organ systems. Dysregulation of complement contributes to the pathogenesis of a number of neurological diseases including stroke.
Saif Ahmad +3 more
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Wet carbonation of C3A and pre-hydrated C3A
Cement and Concrete Research, 2023Sophia Villmow +3 more
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2016
NK-Zellen stellen einen wichtigen Teil der angeborenen Immunantwort dar. Sie sind darüber hinaus in der Lage neoplastische Zellen zu identifizieren und lysieren und damit unschädlich zu machen. Tumorzellen sind in der Lage, sich über verschiedene Mechanismen der immunologischen Kontrolle der NK-Zellen zu entziehen.
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NK-Zellen stellen einen wichtigen Teil der angeborenen Immunantwort dar. Sie sind darüber hinaus in der Lage neoplastische Zellen zu identifizieren und lysieren und damit unschädlich zu machen. Tumorzellen sind in der Lage, sich über verschiedene Mechanismen der immunologischen Kontrolle der NK-Zellen zu entziehen.
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C3a —but not C3a-desarg— is a potent activator of the respiratory burst in human eosinophils
Journal of Dermatological Science, 1993Jörn Elsner +3 more
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