Results 61 to 70 of about 27,277 (237)

Anaphylatoxin C3a but not C3a(desArg) is a chemotaxin for the mouse macrophage cell line J774 [PDF]

European Journal of Immunology, 1998
Varying results have been published regarding the functional reactivity of different cell types, including human monocytes, to the anaphylatoxin C3a and its degradation product C3a(desArg). To further delineate the functions of C3a and C3a(desArg) on this cell type we used the murine macrophage (Mø) cell line J774A.1 which is known to respond to the ...
J, Zwirner, T, Werfel, H C, Wilken, E, Theile, O, Götze   +4 more
openaire   +2 more sources

Microengineering the Liver: Strategies for Constructing Functional Liver‐on‐a‐Chip Devices

Exploration, EarlyView.
This review summarizes recent advances in liver‐on‐a‐chip (LOC) technologies, including fabrication strategies and functional integration approaches, and discusses their promising applications in drug screening and related biomedical fields. ABSTRACT Reliable in vitro liver models are indispensable for researching liver diseases and developing ...
Jie Wang, Ziwei Liang, Jiapu Wang, Zongyi Li, Shaojie Wang, Yan Wei, Xin Xie, Di Huang   +7 more
wiley   +1 more source

An Open‐Label Phase 1b Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of ANX005 in Patients with Huntington's Disease

Movement Disorders, EarlyView.
Complement activation is implicated in Huntington's disease; ANX005 is a potent inhibitor of component C1q. ANX005 exhibited a generally manageable safety profile with rapid reduction in C1q in the cerebrospinal fluid. Functional ability on composite Unified Huntington's Disease Rating Scale and total functional capacity was maintained, with potential ...
Rajeev Kumar, Pinky Agarwal, Karen Anderson, Daniel Claassen, Marissa Dean, Andrew Duker, Burton Scott, Benjamin Hoehn, Ann Mongan, Ping Lin, Ellen Cahir‐McFarland, Lori Taylor, Glenn Morrison, Ted Yednock, Sanjay Keswani, Henk‐Andre Kroon   +15 more
wiley   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

C3a receptor antagonist ameliorates inflammatory and fibrotic signals in type 2 diabetic nephropathy by suppressing the activation of TGF-β/smad3 and IKBα pathway.

PLoS ONE, 2014
ObjectiveDiabetic nephropathy (DN) is a serious complication for patients with diabetes mellitus (DM). Emerging evidence suggests that complement C3a is involved in the progression of DN.
Ling Li, Qinghua Yin, Xi Tang, Lin Bai, Jie Zhang, Shenju Gou, Hongping Zhu, Jingqiu Cheng, Ping Fu, Fang Liu   +9 more
doaj   +1 more source

Anaphylatoxins Activate Ca2+, Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium

Frontiers in Immunology, 2017
PurposeThe retinal pigment epithelium (RPE) is a main target for complement activation in age-related macular degeneration (AMD). The anaphylatoxins C3a and C5a have been thought to mostly play a role as chemoattractants for macrophages and immune cells;
Catharina Busch, Catharina Busch, Balasubramaniam Annamalai, Khava Abdusalamova, Nadine Reichhart, Christian Huber, Christian Huber, Yuchen Lin, Emeraldo A. H. Jo, Peter F. Zipfel, Christine Skerka, Gerhild Wildner, Maria Diedrichs-Möhring, Bärbel Rohrer, Bärbel Rohrer, Olaf Strauß   +15 more
doaj   +1 more source

The complement anaphylatoxin C3a receptor (C3aR) contributes to the inflammatory response in dextran sulfate sodium (DSS)-induced colitis in mice. [PDF]

PLoS ONE, 2013
Inflammatory bowel diseases are a critical public health issue, and as treatment options remain limited, there is a need to unravel the underlying pathomechanisms in order to identify new therapeutic targets.
Elisabeth Wende, Robert Laudeley, André Bleich, Eva Bleich, Rick A Wetsel, Silke Glage, Andreas Klos   +6 more
doaj   +1 more source

Enabling effective urban green space stewardship through planning: A qualitative comparative analysis in Southwest England

People and Nature, EarlyView.
Abstract Amid increasing urbanisation and biodiversity decline, ‘effective stewardship’ of urban green space (UGS) is a complex but critical nature‐based solution for long‐term environmental, social and economic gain. Combining stewardship and sense‐of‐place frameworks with European nature‐based solutions guidance, we investigate which social and ...
Fay Kahane, Melissa Ralph, Rosalind F. Shaw   +2 more
wiley   +1 more source

Quantitative analysis of the aluminate interactions in model and real cement slag pastes at an early age

Case Studies in Construction Materials
The present research investigated the hydration characteristics of model (C3S-C3A-gypsum-blast furnace slag) and real cement slag pastes at an early age, and emphasis was laid on the interaction of gypsum, aluminate phases dissolved from both C3A and ...
Yu Zhang, Chaoyu Liu, Luiz Miranda de Lima Junior, Chen Liu   +3 more
doaj   +1 more source

Quantitative determination of tricalcicum aluminate in portland cement by X-ray diffraction

Materiales de Construccion, 1989
Tricalcium aluminate (C3A) is one of the constitutive phase of the cement-clinker. Its concentration influences the cement behaviour in sulphate aggressive soils. Therefore its quantification is very convenient and International standards fix its content
José Luis Sagrera Moreno
doaj   +1 more source