Results 71 to 80 of about 27,277 (237)

Genomic organization of the human C3a receptor [PDF]

European Journal of Immunology, 1998
The human C3a receptor (C3aR) mediates the activation of cells by the potent proinflammatory chemoattractant C3a, an anaphylatoxin, generated in the early phase of an inflammatory reaction by proteolytic cleavage of the complement component C3. To understand the molecular mechanisms that regulate C3aR gene expression, we initiated studies to determine ...
D, Paral, B, Sohns, T, Crass, M, Grove, J, Köhl, A, Klos, W, Bautsch   +6 more
openaire   +2 more sources

Development of a Novel Polyleucine‐Based Immunopotentiator for Subunit Vaccines Against Group A Streptococcus

Small, EarlyView.
Self‐assembling amphiphilic peptide L15K6 is used as a novel immunoadjuvant for the development of a Group A Streptococcus vaccine. Robust antigen‐specific IgG responses are generated and manage to kill isolated strains of Group A Streptococcus. Cellular and bulk RNA sequencing data reveals that L15K6 regulates immune responses potentially through TLR ...
Lantian Lu, Jazmina L. Gonzalez Cruz, Rabina Giri, Yuexiao Zhang, Sahra Bashiri, Leslie C. Domínguez Cadena, Shuhang Li, Zeinab G. Khalil, Waleed M. Hussein, Jingwen Wang, Jolynn Kiong, Xuehan Lu, Jiahui Zhang, Miao Lu, Wenbin Huang, Wei Yang Kong, Ummey Jannatun Nahar, Prashamsa Koirala, Zhong Guo, Patricia Walden, Antje Blumenthal, Jakob Begun, Kirill Alexandrov, Istvan Toth, Rachel J. Stephenson, Mariusz Skwarczynski   +25 more
wiley   +1 more source

Complement C3a promotes the formation of osteoclasts by inhibiting Sirt1 to activate the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma

Journal of Translational Medicine
Background Myeloma bone disease (MBD) is the most common complication of multiple myeloma (MM). Our previous study showed that the complement C3a activates osteoclasts to participate in the pathogenesis of MBD; however, its mechanism of action is diverse
Fengjuan Jiang, Yunhe Zhang, Fengping Peng, Hui Liu, Kai Ding, Panpan Cao, Xiaohan Liu, Lijuan Li, Zhaoyun Liu, Rong Fu   +9 more
doaj   +1 more source

Microstructural evolution and degradation mechanisms of tricalcium silicate and tricalcium aluminate composite pastes under sulfate exposure

Case Studies in Construction Materials
Sulfate attack precipitates instability and degradation within calcium silicate (aluminate) hydrate (C-(A)-S-H) gel, the primary binding phase in cementitious materials.
Dengke Wang, Gaozhan Zhang, Qingjun Ding, Peng Yan, Yang Li   +4 more
doaj   +1 more source

Macrophage Phenotype–Dependent Protein Corona Formation Governs Ligand Accessibility and Immune Clearance of Biomimetic Nanoparticles

Small, EarlyView.
Macrophage phenotype dictates protein corona composition and immune clearance of biomimetic nanoparticles. M0‐derived membranes minimize opsonin adsorption and complement activation, enabling superior immune evasion and prolonged circulation, thereby providing mechanistic insights for designing long‐circulating nanocarriers.
Tianchang He, Lina Zhu, Jiayi Ding, Xiaoyan Fang, Yu Gao, Volker Mailänder, Daniel Crespy, Katharina Landfester, Shuai Jiang   +8 more
wiley   +1 more source

Two causes of COVID‐19‐related myocardial injury‐associated cardiogenic shock: Myocarditis and microvascular thrombosis

ESC Heart Failure, Volume 12, Issue 2, Page 1514-1522, April 2025.
Takamasa Iwai, Hirohiko Aikawa, Yoshiaki Morita, Keiko Ohta‐Ogo, Teruo Noguchi   +4 more
wiley   +1 more source

Untreated Hair Dye Effluents Enter the Environment: Are They a Threat to Human Health?

Environmental Toxicology, EarlyView.
ABSTRACT The effluents generated during the process of hair dyeing exhibit a complex composition, comprising chemical compounds with varying toxicity levels. While the adverse impact of hair dyes on human health is acknowledged, there is a notable absence of studies addressing the toxicity associated with effluents produced during these activities. The
Letícia Cristina Gonçalves, Matheus Mantuanelli Roberto, Adriana Fabiana Corrêa da Silva, Maria Aparecida Marin‐Morales   +3 more
wiley   +1 more source

The wolf is back! Non‐consumptive effects of the return of a large carnivore on the use of supplementary feeding sites by roe deer

Wildlife Biology, EarlyView.
Understanding how prey species tradeoff predation risk and resource acquisition is particularly important for advancing our knowledge of predator–prey relationships. We investigated this by studying the use of concentrated anthropogenic resources, namely supplementary feeding sites, by roe deer Capreolus capreolus before and after grey wolf Canis lupus
Federico Ossi, Moniek Heurman, Arnaud Bruat, Charlotte Vanderlocht, Benjamin Robira, Nathan Ranc, Simone Dal Farra, Francesca Cagnacci   +7 more
wiley   +1 more source

Generation cycles in experimental populations of a multivoltine insect

Journal of Animal Ecology, EarlyView.
Although theory suggests various mechanisms by which environmental and ecological factors may drive generational fluctuations, our field‐cage experiment is the first to demonstrate how internal dynamics and external disturbances jointly produce synchronised, large‐scale outbreak cycles.
Takehiko Yamanaka, Yasushi Sato, William A. Nelson, Ottar N. Bjørnstad   +3 more
wiley   +1 more source

Knockout of the C3a receptor protects against renal ischemia reperfusion injury by reduction of NETs formation

Cellular and Molecular Life Sciences, 2023
Xiaoting Wu, Danyu You, M. Pan, Mengjie Weng, Qionghong Xie, Y. Guan, Jing Zheng, Songhua Lin, Xiaohong Zhang, Chuan-ming Hao, Jianxin Wan   +10 more
semanticscholar   +1 more source