Results 191 to 200 of about 364,632 (296)

<i>Lactobacillus acidophilus</i> C4 ameliorates constipation in mice. [PDF]

Microbiol Spectr
Yan H, Jia Q, Liu J, Hua X, Cui Y, Jian W, Tan Y, Oduor OS, Thomas P, Kawimbe M, Wu Y, Lu H, Gu T, Tu Z.   +13 more
europepmc   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

Correction: <i>In situ</i> formation of transcriptional modulators using non-canonical DNA i-motifs. [PDF]

Chem Sci
Saha P, Panda D, Müller D, Maity A, Schwalbe H, Dash J.   +5 more
europepmc   +1 more source

Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression

Advanced Science, EarlyView.
Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu, Yalin Liu, Rongyi Wang, Wenwen Xu, Hao Shi, Ning Huang, Junlin Teng, Jin Meng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Crystal structure and Hirshfeld surface analysis of 3-acetyl-11-keto-β-boswellic acid. [PDF]

Acta Crystallogr E Crystallogr Commun
Dinesh B, Shafiulla HN, Shwetha JC, Udaya Kumar AH, Lokanath NK, Anand Solomon K.   +5 more
europepmc   +1 more source

%c3%9cN%c4%b0VERS%c4%b0TELERDE%20L%c4%b0DERL%c4%b0K%20ST%c4%b0LLER%c4%b0%20%c4%b0LE%20%c4%b0%c5%9e%20DOYUMU%20ARASINDAK%c4%b0%20%c4%b0L%c4%b0%c5%9eK%c4%b0

International Journal of Social Humanities Sciences Research (JSHSR), 2018
openaire   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Crystal structures of (<i>S</i>)-3-{1-[(4-chloro-phen-yl)sulfon-yl]piperidin-2-yl}pyridine, (<i>S</i>)-3-[1-(4-methyl-phen-yl)piperidin-2-yl]pyridine, (<i>S</i>)-3-{1-[(4-meth-oxy-phen-yl)sulfon-yl]piperidin-2-yl}pyridine and (<i>S</i>)-3-{1-[(3,4-di-methyl-phen-yl)sulfon-yl]piperidin-2-yl}pyridine. [PDF]

Acta Crystallogr E Crystallogr Commun
Okmanov RY, Olimova MI, Yuldashova IE, Azimova GZ, Pulatova FA.   +4 more
europepmc   +1 more source

Updatable Closed‐Form Evaluation of Arbitrarily Complex Multiport Network Connections

Advanced Electronic Materials, EarlyView.
The inverse design of electrically large wave devices often uses reduced‐order multiport models with discrete optimization, requiring many evaluations of complex interconnections between subsystems that differ only in a few blocks. This paper introduces a closed‐form framework enabling efficient Woodbury low‐rank updates of related, previous ...
Hugo Prod'homme, Philipp del Hougne
wiley   +1 more source

Crystal structure of (3<i>R</i>,5a<i>S</i>,6<i>R</i>,9<i>R</i>,12<i>R</i>,12a<i>R</i>)-3,6,9-tri-methyl-deca-hydro-12<i>H</i>-3,12-ep-oxy[1,2]dioxepino[4,3-<i>i</i>]isochromen-10-yl 5-((3a<i>S</i>,4<i>S</i>,6a<i>R</i>)-2-oxohexa-hydro-1<i>H</i>-thieno[3,4-<i>d</i>]imidazol-4-yl)penta-noate. [PDF]

Acta Crystallogr E Crystallogr Commun
Yang X, Chen S, Liu W, Cui M, Zhao Q.
europepmc   +1 more source