Results 221 to 230 of about 27,324 (243)

The genomic structure of two ancestral haplotypes carrying C4A duplications

Immunogenetics, 1991
Two major histocompatibility complex (MHC) ancestral haplotypes (AH) HLA A24, Bw52, C2C, BfS, C4A3+2, C4BQO, DRw15, DQw6 (52.1) and HLA A24, Cw7, B7, C2C, BfS, C4A3+3, C4B1, DR1, DQw5 (7.2), which occur with the haplotype frequencies of approximately 10% and 4% respectively in the Japanese population, carry duplicated C4A alleles by C4 allotyping ...
K, Tokunaga, W J, Zhang, F T, Christiansen, R L, Dawkins   +3 more
openaire   +2 more sources

C4A deficiency in children and adolescents with recurrent respiratory infections

Human Immunology, 2012
Increased susceptibility to recurrent viral and bacterial respiratory infections in children and young adults is not well understood. To evaluate the role of complement factor C4 in the defense against respiratory infections, we studied complement factor C4 allotypes C4A and C4B and copy numbers of C4A and C4B genes in 84 children and young adults with
Lokki Marja-Liisa, Seppänen Mikko, Lokki Marja-Liisa, Seppänen Mikko, Kainulainen Leena, Ruuskanen Olli, Peltola Ville, Viander Markku   +7 more
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Complement Components C4A and C4B in Human Lupus

2005
For over half a century low serum complement C4 concentrations have been recognized as a manifestation of systemic lupus erythematosus (SLE). However, the role of C4 in human SLE remains elusive. This is partly because of the unusually complex C4 genetics with frequent variations in gene number, gene size, protein isoforms, and expression levels.
Yan Yang, Erwin K. Chung, Karl Lhotta, Yee Ling Wu, Gloria C. Higgins, Robert M. Rennebohm, Lee A. Hebert, Daniel J. Birmingham, Brad H. Rovin, C. Yung Yu   +9 more
openaire   +1 more source

Density functional study of isoalloxazine and C4a-hydroperoxidihydroisoalloxazine

Journal of Molecular Structure: THEOCHEM, 1997
Abstract The structures of isoalloxazine and C4a-hydroperoxidihydroisoalloxazine have been computed at B3LYP/6-31G ∗ level. Solvent effects on relative energies of tautomers and protonation equilibria have been investigated using the SCI-PCM model. The results have been discussed in relation to biochemical properties of flavin coenzymes.
openaire   +1 more source

C4A: A Target Enabling Package

Complement 4A (C4A) is a member of the immune complement factor family that is broadly associated with numerous neurodegenerative pathologies.  C4A is associated with synaptic loss in schizophrenia, a psychiatric disorder with progressive loss of white matter across successive major episodes.
openaire   +1 more source

Human C4 haplotypes with duplicated C4A or C4B.

American journal of human genetics, 1984
In the course of study of families for the sixth chromosome markers HLA-A, C, B, D/DR, BF, and C2, the two loci for C4, C4A, and C4B, and glyoxalase I, we encountered five examples of probable duplication of one or the other of the two loci for C4.
D, Raum, Z, Awdeh, J, Anderson, L, Strong, J, Granados, L, Teran, E, Giblett, E J, Yunis, C A, Alper   +8 more
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C4A copy number is associated with autoimmune disease

Nature Reviews Rheumatology, 2022
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C4As - C4H6 (311 - 383)

2005
G. Schudt-Weitz, I. Strell
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Does complement component C4A protect from autoimmune diseases

Immunology Today, 1997
Beurkens, F.J.M., van Dijk, H., Robins, D.M.   +2 more
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C4A

2011
openaire   +1 more source