Results 11 to 20 of about 7,979 (179)

C53 Interacting with UFM1-Protein Ligase 1 Regulates Microtubule Nucleation in Response to ER Stress

Cells, 2022
ER distribution depends on microtubules, and ER homeostasis disturbance activates the unfolded protein response resulting in ER remodeling. CDK5RAP3 (C53) implicated in various signaling pathways interacts with UFM1-protein ligase 1 (UFL1), which ...
Stanislav Vinopal, Pavel Dráber, Anastasiya Klebanovych   +2 more
exaly   +4 more sources

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress [PDF]

eLife, 2020
Eukaryotes have evolved various quality control mechanisms to promote proteostasis in the endoplasmic reticulum (ER). Selective removal of certain ER domains via autophagy (termed as ER-phagy) has emerged as a major quality control mechanism.
Madlen Stephani, Lorenzo Picchianti, Alexander Gajic, Rebecca Beveridge, Emilio Skarwan, Victor Sanchez de Medina Hernandez, Azadeh Mohseni, Marion Clavel, Yonglun Zeng, Christin Naumann, Mateusz Matuszkiewicz, Eleonora Turco, Christian Loefke, Baiying Li, Gerhard Dürnberger, Michael Schutzbier, Hsiao Tieh Chen, Alibek Abdrakhmanov, Adriana Savova, Khong-Sam Chia, Armin Djamei, Irene Schaffner, Steffen Abel, Liwen Jiang, Karl Mechtler, Fumiyo Ikeda, Sascha Martens, Tim Clausen, Yasin Dagdas   +28 more
doaj   +5 more sources

Analysis of Age, Period and Cohort Trends in Cervical In Situ and Invasive Carcinomas for Assessing the Utility of Screening Approaches—Results From the Saarland Cancer Registry [PDF]

Cancer Medicine
Background Cervical cancer continues to pose a significant public health burden. In Germany, prevention relies heavily on regular screening and HPV vaccination.
Natalie Rath, Klaus Neis, Bernd Holleczek   +2 more
doaj   +2 more sources

Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and C53-mediated autophagy [PDF]

, 2022
UFMylation mediates the covalent modification of substrate proteins with UFM1 (Ubiquitin-fold modifier 1) and regulates the selective degradation of endoplasmic reticulum (ER) via autophagy (ER-phagy) to maintain ER homeostasis.
Grujic, Nenad, Clausen, Tim, Sawa-Makarska, Justyna, Karagoz, Elif G., Karagöz, G. Elif, Ramundo, Silvia, Hornegger, Harald, Martens, Sascha, Zhan, Ni, Richards, Thomas A., Dagdas, Yasin, Picchianti, Lorenzo, Beveridge, Rebecca, Stephani, Madlen, Lendl, Thomas, de Medina Hernández, Víctor Sánchez, Irwin, Nicholas A. T., Sanchez de Medina Hernandez, Victor, G. Elif Karagöz, Yasin Dagdas, Tim Clausen, Ni Zhan, Víctor Sánchez de Medina Hernández, Justyna Sawa-Makarska, Thomas Lendl, Lorenzo Picchianti, Harald Hornegger, Silvia Ramundo, Thomas A. Richards, Rebecca Beveridge, Madlen Stephani, Sascha Martens, Nenad Grujic, Nicholas A. T. Irwin   +33 more
core   +2 more sources

Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy [PDF]

, 2023
UFMylation involves the covalent modification of substrate proteins with UFM1 (Ubiquitin‐fold modifier 1) and is important for maintaining ER homeostasis.
Grujic, Nenad, Groh, Roan, Sawa‐Makarska, Justyna, Karagöz, G Elif, Clausen, Tim, Irwin, Nicholas AT, Sánchez de Medina Hernández, Víctor, Naumann, Christin, Ramundo, Silvia, Hornegger, Harald, Martens, Sascha, Zhan, Ni, Richards, Thomas A, Dagdas, Yasin, Picchianti, Lorenzo, Beveridge, Rebecca, Stephani, Madlen, Lendl, Thomas   +17 more
core   +3 more sources

Stochastic vs. deterministic magnetic coding in designed cylindrical nanowires for 3d magnetic networks [PDF]

, 2021
This work has been carried out under the support of Spanish Ministry of Science and Innovation under Projects MAT2016-76824-C3-1-R, PID2019-108075RB-C31/ AEI / 10.13039/501100011033 and PGC2018-097789-B-I00 and the Regional Government of Madrid under ...
Saugar, Elias, Palmero, Ester M., Pérez del Real, Rafael, Aballe, Lucía, Chubykalo-Fesenko, Oksana, Foerster, Michael, Bran, Cristina, Fraile Rodríguez, Arantxa, Vázquez, Manuel, Asenjo, Agustina, Fernández Roldán, José Ángel   +10 more
core   +1 more source

Forecasting realized volatility through financial turbulence and neural networks

Economics and Business Review, 2023
This paper introduces and examines a novel realized volatility forecasting model that makes use of Long Short-Term Memory (LSTM) neural networks and the risk metric financial turbulence (FT).
Souto Hugo Gobato, Moradi Amir
doaj   +1 more source

MCMC and GLMs for estimating regression parameters: Evidence from non-life Egyptian insurance sector [PDF]

Journal of Humanities and Applied Social Sciences, 2019
Purpose – The purpose of this study is to estimate the linear regression parameters using two alternative techniques. First technique is to apply the generalized linear model (GLM) and the second technique is the Markov Chain Monte Carlo (MCMC) method ...
Mahmoud ELsayed, Amr Soliman
doaj   +1 more source

Value-at-risk predictive performance: a comparison between the CaViaR and GARCH models for the MILA and ASEAN-5 stock markets [PDF]

Journal of Economics Finance and Administrative Science, 2021
Purpose – This paper tests the accuracies of the models that predict the Value-at-Risk (VaR) for the Market Integrated Latin America (MILA) and Association of Southeast Asian Nations (ASEAN) emerging stock markets during crisis periods.
Ramona Serrano Bautista, José Antonio Núñez Mora   +1 more
doaj   +1 more source

Deep Learning Predictive Models for Terminal Call Rate Prediction during the Warranty Period

Business Systems Research, 2020
Background: This paper addresses the problem of products’ terminal call rate (TCR) prediction during the warranty period. TCR refers to the information on the amount of funds to be reserved for product repairs during the warranty period.
Ferencek Aljaž, Kofjač Davorin, Škraba Andrej, Sašek Blaž, Borštnar Mirjana Kljajić   +4 more
doaj   +1 more source