Results 31 to 40 of about 4,217 (211)

Additional file 2 of Morphological neurite changes induced by porcupine inhibition are rescued by Wnt ligands

, 2021
Wnt-C59 prevents accumulation of β-Catenin and increase Wnt3a in L Cells. A. Representative Western blot of β-Catenin levels in L cells that stably express Wnt3a, treated with Wnt-C59 (1 nM and 10 nM C59) for 48 hours. Quantification of β-Catenin protein
Nibaldo C. Inestrosa (304394), Juan A. Godoy (11282848), Jasson Espinoza-Caicedo (6505046)   +2 more
core   +1 more source

Governmental Research Support Programs and Private Entities in Slovakia

Review of Economic Perspectives, 2015
The paper analyses public subsidies aimed to enhance development and innovation in the Slovakian private sector. The paper reviews theoretical approaches of the necessity of public support to research and development activities in order to increase ...
Maliková Zuzana, Kubák Matúš, Bačík Radovan, Fišar Miloš   +3 more
doaj   +1 more source

Analysis of Housing Development Activity in Poland from 2005-2014

Real Estate Management and Valuation, 2016
The growth of both the construction market and the property market depends on various macroeconomic and legal factors, as well as on demographic, institutional, stock and local conditions.
Cellmer Radosław, Jasiński Janusz
doaj   +1 more source

Evaluation of Drug Resistant Genotypes to Fansidar and Chloroquine by Studying Mutation in Pfdhfr and Pfmdr1 Genes in Plasmodium falciparum Isolates from Laghman Province, Afghanistan

Iranian Journal of Parasitology, 2022
Background: Malaria is one of the major health problems in endemic countries like Afghanistan. Evidence has been reported about reducing the effects of chloroquine against Plasmodium falciparum in many endemic countries.
Abdolhossein Dalimi, Sayed Hussain Mosawi, Reza Fotouhi-Ardakani, Ali Dalirghafari   +3 more
doaj   +1 more source

Retracted: Wnt-C59 Attenuates Pressure Overload-Induced Cardiac Hypertrophy via Interruption of Wnt Pathway

Medical Science Monitor, 2023
This publication has been retracted by the Editor due to the identification of non-original figure images and manuscript content that raise concerns regarding the credibility and originality of the study and the manuscript. Reference: Zhengbo Zhao, Han Liu, Yu Li, Jingxiu Tian, Songbai Deng.
Zhao, Zhengbo, Liu, Han, Li, Yu, Tian, Jingxiu, Deng, Songbai   +4 more
openaire   +2 more sources

Models for incomplete nucleophilic attack on a protonated carbonyl group and electron-deficient alkenes : salts and zwitterions from 1-dimethylamino-naphthalene-8-carbaldehyde [PDF]

, 2012
The X-ray crystal structures of salts and zwitterionic Knoevenagel products from 1-dimethylamino-naphthalene-8-carbaldehyde show long N–C bonds between peri-groups which provide models for incomplete nucleophilic attack on a protonated carbonyl group and
Rees, GJ, Pitak, MB, Pitak, Matuesz B., Day, SP, Smith, Mark E., Smith, M.E., Coles, Simon J., Rees, Gregory J., Rees, Gethin, Hanna, John V., Smith, ME, Lari, Alberth, Wallis, J.D., Day, Stephen P., Coles, SJ, Lari, A, Hanna, JV, Pitak, Mateusz, Day, Stephen Paul, Day, S.P., Wallis, JD, Wallis, John D., Hanna, J.V.   +22 more
core   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Wnt Inhibition Sensitizes PD-L1 Blockade Therapy by Overcoming Bone Marrow-Derived Myofibroblasts-Mediated Immune Resistance in Tumors

Frontiers in Immunology, 2021
Cancer-associated fibroblasts (CAFs) has been recognized as one cause of tumor resistance to immune checkpoint blockade therapy, but the underlying mechanisms still remain elusive.
Tinglei Huang, Fuli Li, Xiaojiao Cheng, Jianzheng Wang, Wenhui Zhang, Baiwen Zhang, Yao Tang, Qingli Li, Cong Zhou, Shuiping Tu   +9 more
doaj   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Identification of novel QTLs for isolate-specific partial resistance to Plasmodiophora brassicae in Brassica rapa. [PDF]

PLoS ONE, 2013
Plasmodiophora brassicae, the causal agent of clubroot disease of the Brassica crops, is widespread in the world. Quantitative trait loci (QTLs) for partial resistance to 4 different isolates of P.
Jingjing Chen, Jing Jing, Zhongxiang Zhan, Teng Zhang, Chunyu Zhang, Zhongyun Piao   +5 more
doaj   +1 more source