Results 31 to 40 of about 3,862 (131)

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients

Journal of Experimental & Clinical Cancer Research, 2018
Background Tumor recurrence, the chief reason for poor prognosis of glioma, is largely attributed to glioma stem cells (GSCs) and epithelial-mesenchymal transition (EMT). However, the mechanisms among them remain unknown.
Jin Zhang, Hongqing Cai, Lixin Sun, Panpan Zhan, Meng Chen, Feng Zhang, Yuliang Ran, Jinghai Wan   +7 more
doaj   +1 more source

Enhancing the hemocompatibility of polyethersulfone (PES) hemodialysis membranes using synthesized pseudo zwittronic polymers with various orientations

Results in Surfaces and Interfaces, 2023
The incompatibility of membrane materials with blood in the dialysis process has resulted in extensive number of side effects as well as undesired mortality rates for end-stage renal disease (ESRD) patients.
Anubhab Patra, Jumanah Bahig, Denis Kalugin, Arash Mollahosseini, Ahmed Shoker, Amira Abdelrasoul   +5 more
doaj   +1 more source

Cardiovascular Organoids With Adjustable Endothelial Composition via SOX17‐Engineered hPSCs

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Organoids are considered a novel modeling platform for studying human biology and advancing health research. With the ability to demonstrate complex 3D structure and multicellular interactions, organoids have advanced studies in all major organs as a reliable model.
Po‐Yu Liang, Gyuhyung Jin, Nathan R. Petrucci, Xiaojun Lance Lian, Xiaoping Bao   +4 more
wiley   +1 more source

Economic uncertainty and population health: insights from emerging markets and developing countries

Frontiers in Public Health, 2023
This study employs a Bayesian panel vector autoregressive model to examine the impact of economic uncertainty on public health, using an annual, country-level panel dataset of 103 emerging markets and developing countries spanning the years 1995 through ...
Lin Liu
doaj   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

Inhibition of Wnt/β‐catenin signaling upregulates Nav1.5 channels in Brugada syndrome iPSC‐derived cardiomyocytes

Physiological Reports, 2023
The voltage‐gated Nav1.5 channels mediate the fast Na+ current (INa) in cardiomyocytes initiating action potentials and cardiac contraction. Downregulation of INa, as occurs in Brugada syndrome (BrS), causes ventricular arrhythmias.
Aizhu Lu, Ruonan Gu, Cencen Chu, Ying Xia, Jerry Wang, Darryl R. Davis, Wenbin Liang   +6 more
doaj   +1 more source

Evaluation of ANFIS Predictive Ability Using Computed Sediment from Gullies and Dam

Journal of Nigerian Society of Physical Sciences, 2023
The study proposed an Adaptive Neuro-Fuzzy Inference Systems (ANFIS) model capable of predicting sediment deposited in a dam and sediment loss-in-transit (SLIT) using the potential of a formulated mathematical relation.
Stephen Olushola Oladosu, Alfred Sunday Alademomi , James Bolarinwa Olaleye, Joseph Olalekan Olusina, Tosin Julius Salami   +4 more
doaj   +1 more source

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

Japanese Women's Attitudes Toward Learning Languages Other Than English in the Era of Global English

International Journal of Applied Linguistics, EarlyView.
ABSTRACT This study on female Japanese learners of the Korean language is situated in the centuries‐long anti‐Korean sentiments in Japan, the global popularity of the Korean Wave, particularly among women, and the essentialized image of socially marginalized young Japanese women who study English with romantic desires for Western men.
Yoko Kobayashi
wiley   +1 more source