Results 41 to 50 of about 3,862 (131)

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li   +19 more
wiley   +1 more source

How I Lost My Memory and Never Got It Back

open access: yesEuropean Journal of Life Writing, 2014
This piece is a cross over memoir writing / short story that could also qualify as exilic writing. It emerges from my own experience of immigration and exile to the United States and in particular it tells the story of my last day in my native country of
Domnica Radulescu
doaj   +1 more source

Morpho-functional comparison of differentiation protocols to create iPSC-derived cardiomyocytes

open access: yesBiology Open, 2022
Cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) offer an attractive platform for cardiovascular research. Patient-specific iPSC-CMs are very useful for studying disease development, and bear potential for disease diagnostics ...
Aleksandra Nijak   +16 more
doaj   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

open access: yesAdvanced Science, Volume 13, Issue 43, 3 August 2026.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang   +9 more
wiley   +1 more source

Wnt Signaling Upregulates Teneurin-3 Expression via Canonical and Non-canonical Wnt Pathway Crosstalk

open access: yesFrontiers in Neuroscience, 2019
Teneurins (Tens) are a highly conserved family of proteins necessary for cell-cell adhesion. Tens can be cleaved, and some of their proteolytic products, such as the teneurin c-terminal associated-peptide (TCAP) and the intracellular domain (ICD), have ...
Sussy Bastías-Candia   +7 more
doaj   +1 more source

Convergent targeting of FUNDC1‐dependent mitophagy sensitises and overcomes resistance to EGFR inhibition

open access: yesClinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Nitidine synergises with osimertinib in EGFR‐mutant NSCLC. Nitidine and osimertinib converge on HIF‐1α/FUNDC1‐mediated mitophagy. ABCB6 is required for the nitidine‐associated HIF‐1α/FUNDC1 response. Adaptive FUNDC1 downregulation sensitises osimertinib‐resistant cells to nitidine monotherapy.
Fan Xu   +9 more
wiley   +1 more source

Disposición a pagar por reducir el tiempo de viaje en Tunja (Colombia): Comparación entre estudiantes y trabajadores con un modelo logit mixto

open access: yesLecturas de Economía, 2013
Disposición a pagar por reducir el tiempo de viaje en Tunja (Colombia): Comparación entre estudiantes y trabajadores con un modelo logit mixto Resumen:El estudio analiza la diferencia en la disposición a pagar de estudiantes y trabajadores por reducir el
Luis Márquez
doaj   +1 more source

How Large, Decayed, and Moist Must Rotting Logs Be to Act as Thermally Buffered Microhabitats in Temperate Eastern United States Forests?

open access: yesEcology and Evolution, Volume 16, Issue 5, May 2026.
This study addresses the ecological role of coarse woody debris (CWD) as a thermally buffered microhabitat for saproxylic organisms in temperate eastern US forests. We measured internal and external log temperatures across four seasons in Southern Appalachian forests to test how log diameter, decay stage, and moisture influence thermal buffering.
Ryan T. Phillips, Ryan C. Garrick
wiley   +1 more source

Strain maps characterize the symmetry of convergence and extension patterns during zebrafish gastrulation

open access: yesScientific Reports, 2021
During gastrulation of the zebrafish embryo, the cap of blastoderm cells organizes into the axial body plan of the embryo with left–right symmetry and head–tail, dorsal–ventral polarities.
Dipanjan Bhattacharya   +4 more
doaj   +1 more source

Molecular Mechanisms of Resistance and Treatment Efficacy of Delamanid Against Mycobacterium tuberculosis: A Systematic Review

open access: yesHealth Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Tuberculosis (TB) remains a major global health problem, and treatment progress is increasingly threatened by rising multidrug‐resistant tuberculosis (MDR‐TB). Delamanid (DLM), a nitroimidazole drug, has shown good efficacy and safety against both drug‐susceptible and drug‐resistant Mycobacterium tuberculosis (Mtb) strains.
Md. Mahmudul Islam   +19 more
wiley   +1 more source

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