Results 91 to 100 of about 34,079 (221)

Cancer biomarkers detection using microstructured protein chip: implementation of customized multiplex immunoassay [PDF]

Protein chips have demonstrated to be a sensitive and low cost solution to identify and detect tumor markers. However, efficient multiparametric analysis remains a challenge due to protein variability.
Chevolot, Yann, Choquet-Kastylevsky, Geneviève, Laurenceau, Emmanuelle, Souteyrand, Eliane, Yang, Zhugen, Önal, Yasemin Ataman-   +5 more
core   +1 more source

First-line erlotinib and fixed dose-rate gemcitabine for advanced pancreatic cancer [PDF]

, 2013
AIM: To investigate activity, toxicity, and prognostic factors for survival of erlotinib and fixed dose-rate gemcitabine (FDR-Gem) in advanced pancreatic cancer.
Bria, E., Cognetti, F., Gamucci, T., Gelibter, A., Mansueto, G., Milella, M., Moscetti, L., Ruggeri, E. M., Sperduti, I., Vaccaro, V.   +9 more
core   +1 more source

Single‐Cell Analysis Identified a Recurrent Malignant‐Associated Transcriptional State in Colorectal Cancer

Cancer Science, EarlyView.
Colorectal cancer (CRC) shows high molecular heterogeneity, yet single‐cell data from Japanese patients are limited. We performed scRNA‐seq on tumors and adjacent normal tissues from four Japanese CRC patients and identified a shared malignant cell cluster with high KCNQ1OT1 expression and reduced RASSF6 levels.
Sadahiro Iwabuchi, Kentaro Sawada, Motohiro Kojima, Miho Ozawa, Hiroya Taniguchi, Hideaki Bando, Kazumi Abe, Yuta Kuze, Kiyomi Imamura, Yukie Kashima, Yoshihiko Hirohashi, Atsushi Tajima, Toshihiko Torigoe, Yutaka Suzuki, Takayuki Yoshino, Shinichi Hashimoto   +15 more
wiley   +1 more source

Systematic Multiplatform Discovery of Methylation Markers Enables Non‐Invasive Early Detection of Endometrial Cancer

Cancer Science, EarlyView.
We identified key endometrial cancer DNA methylation biomarkers (ZNF626, GRIA4, SPDYA) from cervical cells. The model achieved high endometrial cancer sensitivity and detected 92.86% of Stage I endometrial cancers using TCT samples. ABSTRACT Endometrial cancer, the most common gynecological malignancy with an annual increase of 1%–3%, lacks suitable ...
Yan Cai, Shuchao Chen, Zhen Wu, Jinxia Guan, Jie Zhao, Jianwei Ye, Baochen Du, Xiaoliang Han, Tong Shu, Guangpeng Zhou, Hong Zheng   +10 more
wiley   +1 more source

A Pilot Study to Develop a Diagnostic Test for Pancreatic Ductal Adenocarcinoma Based on Differential Expression of Select miRNA in Plasma and Bile [PDF]

, 2014
OBJECTIVES: Accurate peripheral markers for the diagnosis of pancreatic ductal adenocarcinoma (PDAC) are lacking. We measured the differential expression of select microRNAs (miRNAs) in plasma and bile among patients with PDAC, chronic pancreatitis (CP),
Cote, Gregory A., Gore, A. Jesse, Heathers, Laura E., Korc, Murray, McElyea, Samantha D., Sherman, Stuart, Xu, Huiping   +6 more
core   +1 more source

Cholangiolocellular Component Predicts a Biologically Distinct Subgroup of Mass‐Forming Intrahepatic Cholangiocarcinoma

Cancer Science, EarlyView.
We identified two distinct molecular subgroups of mass‐forming intrahepatic cholangiocarcinoma (MF‐iCCA) based on the presence of a histological cholangiolocellular carcinoma (CLC) component. The CLC‐related molecular subgroup showed better prognosis and highly angiogenic features, as confirmed by both genetic analysis and morphological observation ...
Naoto Kubota, Ken Yamazaki, Yasuhito Arai, Minoru Esaki, Nobuyoshi Hiraoka, Hirofumi Shirakawa, Moriaki Tomikawa, Tatsuhiro Shibata, Michiie Sakamoto, Hidenori Ojima   +9 more
wiley   +1 more source

Neoadjuvant Docetaxel-Based Chemoradiation for Resectable Adenocarcinoma of the Pancreas [PDF]

, 2010
International audienceTo assess the safety and efficacy of a new neoadjuvant chemoradiation (CRT) docetaxel-based regimen in patients with resectable adenocarcinoma of the pancreatic head or ...
Azria, David, Delpero, Jean-Robert, Giovannini, Marc, Moureau-Zabotto, Laurence, Moutardier, Vincent, Rouanet, Philippe, Turrini, Olivier, Viret, Frédéric, Ychou, Marc   +8 more
core   +3 more sources

Diagnostic Role of CA19-9, CA19-9/CRP Ratio and CA19-9/Total Bilirubin Ratio in Differentiating Benign and Malignant Obstructive Jaundice

Bangladesh Journal of Medicine
Background: Serum carbohydrate antigen (CA19-9) is a tumour marker which is significantly elevated in biliary and pancreatic malignancy. It is also increased in some benign conditions associated with jaundice. So many strategies have been recommended to improve the power of CA 19-9 to differentiate benign and malignant obstructive jaundice.
Mohammad Golam Azam, Ali Arbab Chowdhury, Sarker Mohammed Sajjad, Indrajit Kumar Datta, Md Anisur Rahman, AHM Rowshon   +5 more
openaire   +1 more source

Early‐Onset Digestive System Cancers: Risk Factors and Clinicopathological and Molecular Features Across Organ Sites

Cancer Science, EarlyView.
Shared risk factors, clinical features, and tumor characteristics across multiple early‐onset cancer types are shown in this Graphical Abstract. Integrative approaches combining molecular pathology, oncology, and population sciences offer opportunities to clarify underlying mechanisms and help us develop preventive strategies for early‐onset cancers ...
Nobuhiro Nakazawa, Satoko Ugai, Atsushi Kondo, Kosuke Matsuda, Shu Kato, Genki Usui, Shiori Tanaka, Hwa‐Young Lee, Xinyuan Zhang, Hideo Miyagawa, Mai Chan Lau, Hiroshi Saeki, Yukihide Kanemitsu, Andrew T. Chan, Shuji Ogino, Minkyo Song, Juha P. Väyrynen, Tomotaka Ugai   +17 more
wiley   +1 more source

Prognostic role of inflammatory and tumor biomarkers in hilar cholangiocarcinoma patients receiving postoperative adjuvant therapy

Frontiers in Oncology
BackgroundHilar cholangiocarcinoma (HCCA) is an aggressive cancer with poor prognosis after surgery. The systemic immune-inflammation index (SII) has been proposed as a prognostic marker, but its relationship with other markers such as CA19-9 remains ...
Di Zeng, Di Zeng, Saud Ahmad Saad, Saud Ahmad Saad, Zhen You, Zhen You, Nansheng Cheng, Nansheng Cheng   +7 more
doaj   +1 more source