Results 41 to 50 of about 5,917,592 (236)

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source

The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice [PDF]

, 2019
Glycosylation alterations are indicative of tissue inflammation and neoplasia, but whether these alterations contribute to disease pathogenesis is largely unknown.
Schoepfer, Christina, Da Silva, Brandon, Creighton, Brianna, Spielman, Benjamin, Yu, Kenneth H, Gimotty, Phyllis A, Engle, Dannielle D, Park, Youngkyu, Oni, Tobiloba E, Tiriac, Hervé, Hruban, Ralph H, Tuveson, David A, Afinowicz, Lauren, Whalen, Sean, Rivera, Keith D, Wright, Kevin, Alagesan, Brinda, Lee, Eun Jung, Goggins, Michael G, Hollingsworth, Michael A, Pappin, Darryl J, Grützmann, Robert, Pommier, Arnaud, Aust, Daniela, Lucito, Matthew S, Yao, Melissa A, Pilarsky, Christian, Pollard, Katherine S   +27 more
core   +2 more sources

Prognostic Value of Circulating CA 19-9 in Colorectal Cancer Patients [PDF]

, 2000
Aims: We examined the preoperative serum levels of sialyl Lewisa (CA19-9) and carcinoembryonic antigen (CEA) in 262 colorectal cancer patients, in order to clarify whether or not the prognostic value of CA19-9 after curative surgery is superior to that ...
Kurosaki, Nobuko, Sawai, Terumitsu, Arisawa, Kokichi, Jibiki, Masaaki, Tsuji, Takashi, Yamaguchi, Hiroyuki, Nakagoe, Tohru, Miyashita, Hiroko, Ayabe, Hiroyoshi, Ohbatake, Masayuki, Nakashima, Atsushi, Yasutake, Toru   +11 more
core  

CEA but not CA19-9 is an independent prognostic factor in patients undergoing resection of cholangiocarcinoma

, 2017
Cholangiocarcinoma (CCA) represents a rare form of primary liver cancer with increasing incidence but dismal prognosis. Surgical treatment has remained the only potentially curative treatment option, but it remains unclear which patients benefit most ...
Longerich, Thomas, Koch, Alexander, Anne T. Schneider, Tom F. Ulmer, Tom Luedde, Schneider, Anne T., Marcel Binnebösel, Binneboesel, Marcel, Ulf P. Neumann, Christian Trautwein, Alexander Koch, Georg Lurje, Vucur, Mihael, Wenzel Schoening, Trautwein, Christian, Katja L. Kauertz, Roderburg, Christoph, Sven H. Loosen, Lurje, Georg, Tacke, Frank, Christoph Roderburg, Loosen, Sven H., Ulmer, Tom F., Frank Tacke, Kauertz, Katja L., Neumann, Ulf P., Binnebösel, Marcel, Cornelis H. Dejong, Dejong, Cornelis H., Mihael Vucur, Luedde, Tom, Schoening, Wenzel, Thomas Longerich   +32 more
core   +1 more source

Bio‐Memristor Based on Clinical Bile Samples: A Proof‐of‐Concept Pilot Study for Detection of Gallbladder Cancer

Advanced Science, EarlyView.
In this work, we present a bile‐based memristor hardware framework that enables direct, label‐free identification of cholelithiasis and gallbladder cancer at the device level. The Ag/bile/FTO memristor features stable resistive switching and disease‐specific electrical responses, providing a conceptual foundation for circuits and an integrated ERCP ...
Junming Zhu, Yiyin Rong, Bai Sun, Ziwen Sun, Yifan Wang, Xiaobin Ren, Zelin Cao, Kaikai Gao, Jiawei Yu, Zhenkun Wang, Haoxuan Ma, Jichun Guo, Kai Cao, Mengrun Kang, Songling Wang, Fenggang Ren, Yi Lv, Qiang Lu   +17 more
wiley   +1 more source

A case of acute cholecystitis with abnormally high CA19-9

, 2023
Background CA19-9 is strongly expressed in malignant tumors of the digestive system and is widely used as a marker for gastrointestinal cancer. In this report, we describe a case of acute cholecystitis in which CA19-9 was markedly elevated.
Hironobu Kimura, Noboru Yokoyama, Shinichiro Oinuma, Shinya Kasagi, Haruhiro Inoue, Takuya Terunuma, Syunsuke Omotaka, Deguchi Yoshio   +7 more
core   +1 more source

Immunomagnetic‐MXene Bifunctional Probes for Ultrasensitive and Specific Terahertz Metasensing of Tumor‐Derived Exosomes

Advanced Science, EarlyView.
An immunomagnetic‐MXene bifunctional probe integrated with THz metamaterials enables ultrasensitive and specific detection of pancreatic cancer‐derived exosomes. Dual biomarker recognition ensures high specificity, while MXene signal amplification achieves a detection limit of 647 particles mL−1.
Weidong Jin, Jiyue Chen, Fengxin Xie, Huiyan Tian, Xuechen Dou, Yanqi Han, Lu Zhang, Jining Li, Xiang Yang   +8 more
wiley   +1 more source

Colorectal cancer: Impact of CEA and CA19-9

, 2023
Colorectal cancer is the third most common cancer world-wide. A diagnosis in early stages, adequate treatment, and a follow-up is vital for a good prognosis in overall and recurrence-free survival. While the tumor marker carcinoembryonic antigen (CEA) is
Lakemeyer, Leilani Ellen
core   +1 more source

Age‐Dependent Prognostic Significance of Preoperative Transthyretin After Curative Resection for Stage I–III Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Preoperative malnutrition and systemic inflammation are established determinants of adverse outcomes in colorectal cancer (CRC). Transthyretin (TTR), a rapid‐turnover hepatic protein, reflects both nutritional and inflammatory status; however, its clinical utility may be influenced by age‐ and sex‐related variability.
Ayane Kawata, Yuji Miyamoto, Hiro Nakamura, Takahiko Akiyama, Kota Arima, Katsuhiro Ogawa, Yukiharu Hiyoshi, Masaaki Iwatsuki   +7 more
wiley   +1 more source

Changes of CA19-9 levels and related influencing factors in patients with type 2 diabetes mellitus after antidiabetic therapy

Scientific Reports
Abnormalities of carbohydrate antigen 19 − 9 (CA19-9) are common in patients with type 2 diabetes mellitus (T2DM), and in some patients, CA19-9 returns to normal level after glycemic control.
Xiafei Zhao, Yan Wang, Ling Zhou, Aili Ye, Quanfeng Zhu   +4 more
doaj   +1 more source