USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
I MARKERS TUMORALI CA 125, CA 15-3, CA 19-9, IN PAZIENTI AFFETTE DA NEOPLASIE DEL CORPO UTERINO
, 1993 Abbiamo analizzato i valori sierici di Ca 125, Ca 15-3 e Ca 19-9 in pazienti affette da neoplasia del corpo uterino al fine di valutarne la possibilita' di impiego nel monitoraggio di tale patologia.
G. Capraro +3 more
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Integrated Biomarker Assessment for Prognosis in Canine Mammary Carcinomas: Complementary Roles of Serum CA 15-3 and Immunohistochemistry Ki-67, and COX-2. [PDF]
Animals (Basel)Pinheiro BQ +6 more
europepmc +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
Archivio d’Annunzio. Rivista di Studi comparati
A journal that arises in a completely original way than other publications and supplements dedicated to the Immaginifico and considers the figure of Gabriele d’Annunzio as an eponymous sample of an interdisciplinary and multicultural vision, as suggested
Università Ca\u27 Foscari Venezia - Dipartimento di Studi Umanistici
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Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
Sensitive determination of breast cancer biomarker, CA 15-3, using a label free electrochemical aptasensor based on palladium nanoparticles decorated carbon nanofibers. [PDF]
Sci RepNayeri M, Seifati SM, Nasirizadeh N.
europepmc +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Portrait of Daryl Lindsay, ca. 1930 [picture] /
, 1930 Title devised by cataloguer based on inscription and other reference sources.; Part of the Sir Lionel Lindsay collection of photographs of family and friends, ca. 1880-ca. 1960.; Inscriptions: "Daryl Lindsay"--In ink on verso.; Condition: Sm. scratches.;
Lindsay, Lionel, Sir, 1874-1961.
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