Results 81 to 90 of about 26,342,767 (265)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Serum CA 549, CA 19-9, CA 15-3, and CEA Levels in Patients With Breast Cancer

Eurasian Journal of Medicine, 2019
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Mahmut C. Başoğlu, Sabri Selçuk Atamanalp, M. İlhan Yıldırgan, Cafer Polat, Leyla Yıldız, K.Yalçın Polat, M.Sait Keleş, Sevinç Kuşkay   +7 more
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Serum biomarkers (CA 15-3, CEA) and hormonal receptor status as predictors of breast cancer recurrence

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Breast cancer is a heterogenous malignancy and is one of the leading causes of cancer-related mortality in women worldwide. Recurrence as a barrier to long-term survivorship and effective patient management is a formidable challenge.
Muntaha Maddah Al Alouci, Fatima Mallallah Mohammed, Zainab M. Qassam, Osama A. Mohsein   +3 more
doaj   +1 more source

Serum miR-16 and CA15.3 combination as early diagnostic biomarkers for breast cancer in Egyptian females [PDF]

Egyptian Journal of Pure and Applied Science
Background: Breast cancer (BC) represents one of the most lethal malignancies among women worldwide. MiRNAs play an important role in breast cancer diagnosis and progression. Inconsistent data about the expression level of miR-16 was reported in BC, thus
Sara Kamal, Doaa Ibrahim, Reham Elshimy, Walid Zahran   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes [PDF]

, 2008
BACKGROUND: To investigate the association between tumor markers [cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA)] and clinicopathological parameters and patient outcomes in breast cancer.
김주희, 오재원, 박병우, 박세호   +3 more
core   +1 more source

CA 15-3, CRP, and LDH correlates with prognostic parameters in canine mammary neoplasms. [PDF]

Anim Reprod, 2023
Pinheiro BQ, de Magalhães FF, Alves FWDS, Silva ING, Faustino AMR, da Silva LDM.   +5 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Time Series measurements of White Blood Cells (WBC) and plasma Cancer Antigen 15-3 (CA 15-3) in a patient with metastatic breast cancer, serving as a reference for assessing the clinical relevance of different clustering algorithms.

Applied Medical Informatics
Clustering is highly valuable for analyzing cancer marker time series data. In a recent study, the significance of the K-means clustering algorithm was examined for the first time in evaluating time-series measurements of plasma Cancer Antigen 15-3 (CA ...
Alexandros CLOUVAS
doaj