Results 111 to 120 of about 26,342,767 (265)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Bollettino di Ca\u27 Foscari n. 1 - 1968. Associazione "Primo Lanzoni" tra gli antichi studenti di Ca\u27 Foscari Venezia

open access: yes, 1968
Il Bollettino n. 1 del 1968, il primo dell\u27ultima serie del periodico, dopo una premessa del presidente dell\u27Associazione, Giampiero Franco, sulle modifiche apportate dal Consiglio allo Statuto della Facoltà di Economia e Commercio, entra nel ...
Associazione Primo Lanzoni tra gli antichi studenti di Ca\u27 Foscari Venezia
core  

Thiol-mediated electrochemical sensor for the breast cancer biomarker CA 15-3

open access: yesFrontiers in Sensors
Cancer antigen 15-3 (CA 15-3), a circulating fragment of the MUC1 glycoprotein, is widely used for monitoring breast cancer progression. In this study, we report a label-free, receptor-free electrochemical detection strategy based on adsorption-mediated ...
Nastaran Ghaffari, Priscilla Baker
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Point Pinos, California, ca. 1850 [picture].

open access: yes
In: Watercolours of a voyage around South America to the Society Islands and Hawaii, ca.1850.; Rex Nan Kivell Collection NK2602/15.; Title from inscription lower ...

core  

Clinical Evaluation of the Levels of CEA,CA15-3 and AlphaFeto Protein in Malignant and Benign Pleural Effusion

open access: yesمجله كليه طب الكندي, 2008
Background: Pleural effusion is a common clinical problem. Objective: The aim of the study was to evaluate the diagnostic utility of Carcino embryonic antigen (CEA), CA 15- 3, and alpha-feto protein ( AFP ) as a tumor markers in serum and pleural ...
Zina Anwer Salloum Marrow   +3 more
doaj  

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