Results 81 to 90 of about 3,242,059 (273)

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Serum biomarkers (CA 15-3, CEA) and hormonal receptor status as predictors of breast cancer recurrence

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Breast cancer is a heterogenous malignancy and is one of the leading causes of cancer-related mortality in women worldwide. Recurrence as a barrier to long-term survivorship and effective patient management is a formidable challenge.
Muntaha Maddah Al Alouci, Fatima Mallallah Mohammed, Zainab M. Qassam, Osama A. Mohsein   +3 more
doaj   +1 more source

Serum miR-16 and CA15.3 combination as early diagnostic biomarkers for breast cancer in Egyptian females [PDF]

Egyptian Journal of Pure and Applied Science
Background: Breast cancer (BC) represents one of the most lethal malignancies among women worldwide. MiRNAs play an important role in breast cancer diagnosis and progression. Inconsistent data about the expression level of miR-16 was reported in BC, thus
Sara Kamal, Doaa Ibrahim, Reham Elshimy, Walid Zahran   +3 more
doaj   +1 more source

Evaluation of CEA, TPA, CA 15-3, CA 549 and TPS in the monitoring of metastatic breast cancer

, 1993
Monitoring the response to treatment in relapsed breast cancer patients is one of the chief uses of tumor markers. Thus far the carcinoembryonic antigen (CEA)-tissue polypeptide antigen (TPA)-breast cancer associated antigen 115 D8/DF3 (CA 15-3 ...
Nicolini A, FERDEGHINI, Marco, Colizzi C.   +2 more
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Serum NSE, CEA, CT, CA 15-3 Levels in Human Lung Cancer

The International Journal of Biological Markers, 1990
The significance of neuron specific enolase (NSE) was investigated in comparison with other tumor markers (CEA, CT, CA 15-3) used in the diagnosis and treatment monitoring of lung cancer.
S. Nutini, G. Cappelli, A. Benucci, C. Catalani, F. Nozzoli   +4 more
doaj   +1 more source

CA 15-3, CRP, and LDH correlates with prognostic parameters in canine mammary neoplasms. [PDF]

Anim Reprod, 2023
Pinheiro BQ, de Magalhães FF, Alves FWDS, Silva ING, Faustino AMR, da Silva LDM.   +5 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Seawater nutrient and carbonate ion concentrations recorded as P/Ca, Ba/Ca, and U/Ca in the deep-sea coral D. dianthus [PDF]

, 2011
As paleoceanographic archives, deep sea coral skeletons offer the potential for high temporal resolution and precise absolute dating, but have not been fully investigated for geochemical reconstructions of past ocean conditions.
LaVigne, Michele, Alex Gagnon, Michele LaVigne, Eleni Anagnostou, Sherrell, Robert M., Gagnon, Alex, McDonough, William F., M. Paul Field, William F. McDonough, Anagnostou, Eleni, Field, M. Paul, Robert M. Sherrell   +11 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source