Results 121 to 130 of about 3,242,059 (273)

Ocean beach, Manley [i.e. Manly], ca. 1885, [3] [picture].

, 1885
In: Album of photographs of Sydney, and Queensland Botanic Gardens, ca. 1885.; Title from caption on mount.; Condition: Glued to mount.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic ...

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IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CA 15-3 [PDF]

, 2019
openaire   +2 more sources

I MARKERS TUMORALI CA 125, CA 15-3, CA 19-9, IN PAZIENTI AFFETTE DA NEOPLASIE DEL CORPO UTERINO

, 1993
Abbiamo analizzato i valori sierici di Ca 125, Ca 15-3 e Ca 19-9 in pazienti affette da neoplasia del corpo uterino al fine di valutarne la possibilita' di impiego nel monitoraggio di tale patologia.
G. Capraro, T. Zen, P. Padovan, LITTA, PIETRO SALVATORE   +3 more
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Porto Santo off Madeira, ca. 1850 [picture].

In: Watercolours of a voyage around South America to the Society Islands and Hawaii, ca.1850.; Rex Nan Kivell Collection NK2602 ...

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B12 Vitamin Eksikliğine Bağlı Megaloblastik Anemi ile Ca 15-3 İlişkisi: Olgu Sunumu

, 2015
CA 15-3 bazı kanser ve iyi huylu hastalıklarda yükselebilen glikoprotein yapıda bir belirteçtir. Megaloblastik anemi- nin en yaygın sebebi vitamin B12 ve/veya folik asit eksikliğidir.
KEREN, Fatma, BALÇIK, Şahin, KOŞAR, Ali, TANRIKULU, Eda ŞİMŞEK   +3 more
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