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Current Therapeutic Targets in Cancer Cachexia: A Pathophysiologic Approach.
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 2023Significant progress in our understanding of cancer cachexia has occurred in recent years. Despite these advances, no pharmacologic agent has achieved US Food and Drug Administration approval for this common and highly morbid syndrome.
Kunal C. Kadakia +2 more
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Drugs of Today, 2016
Cachexia is a multiorgan, multifactorial and often irreversible wasting syndrome associated with cancer and other serious, chronic illnesses including AIDS, chronic heart failure, chronic kidney disease and chronic obstructive pulmonary disease. Treatment of the patient with cachexia is currently targeted to correcting the two underlying features of ...
A I, Graul, M, Stringer, L, Sorbera
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Cachexia is a multiorgan, multifactorial and often irreversible wasting syndrome associated with cancer and other serious, chronic illnesses including AIDS, chronic heart failure, chronic kidney disease and chronic obstructive pulmonary disease. Treatment of the patient with cachexia is currently targeted to correcting the two underlying features of ...
A I, Graul, M, Stringer, L, Sorbera
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International Journal of Oncology, 1997
Cancer cachexia is a complex syndrome accounting for nearly a third of cancer deaths, characterized by weight loss, anorexia, weakness, anaemia and asthenia. The complications associated with the appearance of the cachectic syndrome affect both the physiological and biochemical balance of the patient, and have effects on the efficiency of the ...
J, Argiles, F, Lopezsoriano
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Cancer cachexia is a complex syndrome accounting for nearly a third of cancer deaths, characterized by weight loss, anorexia, weakness, anaemia and asthenia. The complications associated with the appearance of the cachectic syndrome affect both the physiological and biochemical balance of the patient, and have effects on the efficiency of the ...
J, Argiles, F, Lopezsoriano
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International journal of pancreatology, 1990
Cancer cachexia has been listed as a major cause of death in cancer patients. In order to investigate the metabolic effects of the tumor on the host, we have evaluated an experimental model of cancer cachexia in the mouse (MAC16 colon adenocarcinoma), in which weight loss can reach 30-40% of initial weight with a tumor burden of only 2.5%, without a ...
M J, Tisdale, S A, Beck
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Cancer cachexia has been listed as a major cause of death in cancer patients. In order to investigate the metabolic effects of the tumor on the host, we have evaluated an experimental model of cancer cachexia in the mouse (MAC16 colon adenocarcinoma), in which weight loss can reach 30-40% of initial weight with a tumor burden of only 2.5%, without a ...
M J, Tisdale, S A, Beck
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International Journal of Cardiology, 2002
Cancer cachexia is a complex, multifactorial syndrome that results from a reduction in food intake, a variety of metabolic abnormalities (including hypermetabolism) or more often a combination of the two. Multiple mediator pathways including pro-inflammatory cytokines, neuroendocrine hormones and tumour-specific factors are involved. Therapy requires a
Kenneth C H, Fearon, Alastair G W, Moses
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Cancer cachexia is a complex, multifactorial syndrome that results from a reduction in food intake, a variety of metabolic abnormalities (including hypermetabolism) or more often a combination of the two. Multiple mediator pathways including pro-inflammatory cytokines, neuroendocrine hormones and tumour-specific factors are involved. Therapy requires a
Kenneth C H, Fearon, Alastair G W, Moses
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Clinical Journal of Oncology Nursing
Cancer cachexia is characterized by metabolic dysregulation, inflammation, and reduced food intake, and it results in loss of skeletal muscle. Although cachexia is pervasive in patients with advanced cancer, comprehensive cac.
Michael S Yule +3 more
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Cancer cachexia is characterized by metabolic dysregulation, inflammation, and reduced food intake, and it results in loss of skeletal muscle. Although cachexia is pervasive in patients with advanced cancer, comprehensive cac.
Michael S Yule +3 more
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Critical Reviews in Oncology/Hematology, 1987
Cancer cachexia is a complex syndrome that includes host tissue wasting, anorexia, asthenia, and abnormal host intermediary metabolism. It is present in approximately 50% of cancer patients during treatment and nearly 100% of treated cancer patients at death. Cachexia has a detrimental impact on cancer therapy. The central problem of cancer cachexia is
Jeffrey A. Norton +3 more
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Cancer cachexia is a complex syndrome that includes host tissue wasting, anorexia, asthenia, and abnormal host intermediary metabolism. It is present in approximately 50% of cancer patients during treatment and nearly 100% of treated cancer patients at death. Cachexia has a detrimental impact on cancer therapy. The central problem of cancer cachexia is
Jeffrey A. Norton +3 more
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Annals of Internal Medicine, 2000
Cachexia represents the clinical consequence of a chronic, systemic inflammatory response, and its manifestations differ considerably from those of starvation. Although cachexia is classically associated with chronic infections and malignant conditions, some of its elements have been identified in a wide variety of chronic diseases and in aging persons.
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Cachexia represents the clinical consequence of a chronic, systemic inflammatory response, and its manifestations differ considerably from those of starvation. Although cachexia is classically associated with chronic infections and malignant conditions, some of its elements have been identified in a wide variety of chronic diseases and in aging persons.
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Surgical Oncology, 1999
Cachexia is a common cause of morbidity and mortality in patients with advanced cancer. It is characterised by numerous metabolic abnormalities including inefficient substrate utilisation, alterations in the balance of energy intake and expenditure and the acute-phase protein response.
M D, Barber, J A, Ross, K C, Fearon
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Cachexia is a common cause of morbidity and mortality in patients with advanced cancer. It is characterised by numerous metabolic abnormalities including inefficient substrate utilisation, alterations in the balance of energy intake and expenditure and the acute-phase protein response.
M D, Barber, J A, Ross, K C, Fearon
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Ponsegromab for the Treatment of Cancer Cachexia.
New England Journal of MedicineBACKGROUND Cachexia is a common complication of cancer and is associated with an increased risk of death. The level of growth differentiation factor 15 (GDF-15), a circulating cytokine, is elevated in cancer cachexia.
John D. Groarke +16 more
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