Results 111 to 120 of about 979,106 (300)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Data model for biopart datasheets
Engineering Biology, 2018 This study introduces a new data model, based on the DICOM-SB (see glossary of terms for definition of acronyms) standard for synthetic biology, that is capable of describing/incorporating the data, metadata and ancillary information from detailed ...
Iñaki Sainz de Murieta +2 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Евразийский Кардиологический ЖурналAmong the most dangerous causes of mortality worldwide, coronary artery disease (CAD) remains the leading cause. Despite the fact that atherosclerosis of the coronary arteries is the main cause of the development of coronary artery disease, clinicians ...
E. A. Khachirova, M. D. Iarovoi
doaj +1 more source
Zhejiang Daxue xuebao. Lixue ban, 2012 为提高CAD和GIS数据转换的效率和准确性，利用语义映射关系和生物种群进化的思想，设计了 一种用于数据转换的语义适配器，提出了一套实用、高效的数据转换模型.实例表明，该模型具有较好的实用价值，在一定程度上能够解决CAD和GIS数据智能转换的问题.
XUFang-bin(徐方斌) +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
International Journal of General Medicine, 2023 Guo-Li Du,1,2,* Fen Liu,1,3,4,* Hua Liu,1,2,* Qi Meng,1,2 Ran Tang,1,2 Xiao-Mei Li,1,3 Yi-Ning Yang,1,5 Xiao-Ming Gao1,3,4 1State Key Laboratory of Pathogenesis, Prevention, and Treatment of High Incidence Diseases in Central Asia, Urumqi ...
Du GL +7 more
doaj
Cylindrical Algebraic Decomposition Using Local Projections
, 2014 We present an algorithm which computes a cylindrical algebraic decomposition of a semialgebraic set using projection sets computed for each cell separately.
Strzebonski, Adam
core +1 more source